M. Strueber's research while affiliated with Beth Israel Medical Center and other places

Publications (234)

Article
Purpose This is the first assessment of cost-effectiveness of Left Ventricular Assist Device (LVAD) implantation via thoracotomy. Cost effectiveness of LVADs implanted through the traditional surgical approach of sternotomy has been improved through the years due to technological advances, along with understanding the importance patient selection a...
Article
Full-text available
Purpose Heart transplant for patients with left ventricular assist device (LVAD) often requires long cardiopulmonary bypass and increased blood product use. Hypothesis was made that a donor heart should not be undersized so that it can tolerate complicated surgery. We evaluated the impact of donor-to-recipient size matching on outcome after heart t...
Article
Purpose Less invasive techniques for Left Ventricular Assist Device (LVAD) implantation have been increasingly prevalent over the last years and have been associated with improved clinical outcomes. The procedural economic impact of these techniques remains unknown. We sought to study and report economic outcomes associated with the thoracotomy imp...
Article
Purpose Everolimus is a proliferation signal inhibitor used for triple immunosuppressive therapy following solid organ transplantation. Its positive benefits, such as reduction of acute rejection episodes and reduced nephrotoxicity have been shown in kidney- as well as heart transplantation. However the role of everolimus is less well defined in lu...
Article
Full-text available
Background. There is little information about the anesthesiologic management of lung transplantation. Therefore, we characterized intraoperative variables and their impact on survival in dependence to preoperative characteristics of recipients and donors. Methods. We analyzed 808 lung transplantations performed at our institution between 1987 and 2...
Chapter
In diesem Kapitel werden die derzeit klinisch einsetzbaren intra- und parakorporalen Systeme zur mechanischen Langzeit-Kreislaufunterstützung vorgestellt. Hierbei werden neben technischen Aspekten auch die systemspezifischen Implantationsabläufe aufgeführt.
Article
Background: The rotary blood pump (HVAD) from HeartWare is an established left ventricular assist device and usually implanted via sternotomy and the use of cardiopulmonary bypass. To reduce the side effects of a heart-lung machine, the implant procedure was done off pump via upper hemisternotomy and left anterolateral minithoracotomy. Methods: Bet...
Article
Linksventrikuläre Unterstützungssysteme haben eine zunehmende Bedeutung in der Therapie der terminalen Herzinsuffizienz. Mittlerweile werden pro Jahr mehr Implantationen von Unterstützungssystemen als Herztransplantationen durchgeführt. Durch verbesserte Indikationsstellungen und Pumpen konnte das Einjahresüberleben auf 84 % gesteigert werden. Die...
Article
The aim of this study was to assess performance of the new lung allocation system in Germany based on lung allocation score (LAS). Retrospective analysis of waitlist (WL) outflow, lung transplantation (LTx) activity and 3-month outcomes comparing 1-year pre- and post-LAS introduction on December 10, 2011 was performed. Following LAS introduction, W...
Article
Objectives: Assist devices are an essential option in treatment of advanced heart failure. Despite all technical improvements, pump thrombosis is a severe complication and only indirect diagnostic tools are available. Rotation of the VAD impeller creates a specific sound pattern, that can be recorded and analyzed. In this pilot study, we recorded a...
Article
Purpose The REVOLVE Registry is an investigator-initiated registry established to collect data on the commercial use of the HeartWare® HVAD System in the European Union and Australia. Methods and Materials REVOLVE is a multi-center, prospective, single arm registry. Each patient is followed to device explant, transplantation or death. Data from th...
Article
Left ventricular assist devices (LVAD) are gaining more importance in the treatment of heart failure. The constant development of novel technologies in this field is being reflected by enhanced and considerably miniaturized LVAD-systems. However from a surgical point of view, complications like bleeding or right ventricular failure with liver impai...
Article
The rotary blood pump (HVAD) from HeartWare is an established left ventricular assist device and usually implanted via sternotomy. To reduce the invasiveness of the implant procedure and to optimize the position of the inflow cannula we propose a different implant technique with an extrapericardial placement of the pump via left anterolateral minit...
Article
The Lung Allocation Score (LAS), first introduced in the United States in 2005, was developed with the aim of allocating organs based on predicted transplant benefit. Analysis of its impact in the US revealed reduced waiting times, increased numbers of procedures and decreased mortality amongst listed patients. Transplant survival appeared unchange...
Article
The CircuLite® Synergy® System, a micro-pump based assist device, has been optimized to improve performance in an EU clinical trial for chronic ambulatory heart failure patients. We report the results from the last 24 consecutive patients.Methods and Materials24 non-inotrope dependent (INTERMACS ≥4; 20 males, 61±15yrs, EF 20±5%) patients were impla...
Article
Data from previous studies show that everolimus can facilitate CNI minimization with comparable efficacy and safety, while simultaneously reducing CNI-induced chronic nephropathy in transplant recipients. The 4EVERLUNG study (NCT01404325) aims to evaluate the impact of a “quadruple low” immunosuppressive regimen on renal function, safety and effica...
Article
Objectives: Durability of ventricular assist device (VAD) therapy improved steadily over the past years. However, driveline infections remain a challenge. Methods: To test whether an improved surgical implantation technique may lower incidence of infections, we analyzed all patients receiving a VAD implantation in the years 2008 and 2009 (group 1)...
Article
Objectives: The use of organ supporting systems with blood contacting surfaces is inter alia limited by activation of the coagulation system. Especially inflow cannulas of LVAD-systems present thrombus formation resulting in the exchange of the system. Driven by advances in regenerative medicine, endothelial cell seeding is considered to be an impo...
Article
Objectives: Cardiac transplantation remains to be the treatment of choice for patients suffering from end-stage heart disease. Advances made in this field have led to improved survival rates and increased numbers of patients on the waiting list. Reclassification of selection criteria concerning donors and recipients poses an option to reduce the ga...
Article
Objectives: In the daily life with VADs, the safe and intuitive use of the systems including the peripheral components is not only a question of life quality, but sometimes even crucial. To investigate the advantages and disadvantages of the different systems and to get patient feedback on preferable features, a multicenter study was initiated. Me...
Article
Objective: Extracorporeal membrane oxygenation (ECMO) is a well-established treatment for severe cardiopulmonary failure. Due to the necessity of vascular access, patients undergoing ECMO-support are at risk of vascular complications (VC). Aim of this study was to review such complications in order to increase understanding of ECMO access technique...
Article
Objectives: Patients' perceptions of immunosuppression-related symptom experience impacts on QoL and medication adherence. This study meant to investigate patients' responses to immunosuppression-related side effects with emphasis on gender-specific issues. Methods: 285 HTx recipients (response rate 91.6%) were asked to report on symptom experienc...
Article
Herpesvirus infections cause morbidity in lung transplant recipients. The study was conducted to investigate the incidence and impact of herpes simplex virus (HSV) and cytomegalovirus (CMV) detection in the respiratory tract (RT) of lung and heart-lung transplant recipients (LTR) during the postoperative phase. In a prospective cohort study, 91 LTR...
Article
We report on the use of veno-arterial extracorporeal membrane oxygenation (ECMO) as a bridging strategy to lung transplantation in awake and spontaneously breathing patients. All five patients described in this series presented with cardiopulmonary failure due to pulmonary hypertension with or without concomitant lung disease. ECMO insertion was pe...
Article
Full-text available
This article describes multiple transmissions of rabies via transplanted solid organ from a single infected donor. The empirical Milwaukee treatment regimen was used in the recipients. Symptomatic patients were treated by deep sedation (ketamine, midazolam, and phenobarbital), ribavirin, interferon, and active and passive vaccination. Viral loads a...
Article
Objectives: In our VAD program we can define two major changes of strategies. First we went from pulsatilen devices to nonpulsatile devices in 2004. And second, we introduced a period of patient „conditioning“ in 2007: This includes the use of pharmacotherapy and temporary assist devices (ECMO) to improve the patient status prior to implant, thus a...