M. Ruel's research while affiliated with University of Ottawa and other places

Publications (110)

Article
BACKGROUND Mitral valve repair is the gold standard therapy for the treatment of degenerative mitral regurgitation (MR). Although outcomes following surgical mitral valve repair have been well described, few data are available on the longitudinal performance of mitral repair for patients according to the age at surgery. These data are particularly...
Article
BACKGROUND Aortic valve repair (AVr) has emerged as a feasible and effective alternative to replacement (AVR) in patients with aortic insufficiency (AI), however, little data exists comparing outcomes. Thus, the objective of this study was to compare early and long-term valve related complications between AVr and AVR in the treatment of AI. METHOD...
Article
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We describe the case of a 64-year-old female presenting with severe prosthetic MV endocarditis 1 year after CABG and double valve replacement. Echocardiogram revealed high-pressure gradients through the bioprosthetic MV with a bulky vegetation. As the patient had presented operative difficulties due to severe mitral annular calcification (MAC), was...
Article
Full-text available
Background Cardiogenic shock (CS) is associated with high mortality. We report on a ‘Shock Team’ approach of combined interdisciplinary expertise for decision making, expedited assessment and treatment. Methods and Results We reviewed 100 patients admitted in CS over 52 months. Patients managed under a Code Shock Team protocol (n=64, treatment) du...
Book
This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomate...
Chapter
Endothelial progenitor cell (EPC) therapy has emerged as a promising treatment in cardiac regeneration. EPCs are capable of promoting neovascularization within ischemic tissues, but past studies have had limited success in vivo due to the poor retention and survival of cells within the injured area. In addition, the environment into which the cells...
Chapter
In surgical repair for heart disease, it is often necessary to implant conduits or correct tissue defects. Commonly used graft materials include artifi cial grafts, autologous tissues, allografts and xenografts. However, none of these offer growth potential, and all are associated with varying levels of thrombogenicity and susceptibility to infecti...
Article
Electrical storm refers to a state of cardiac electrical instability characterized by multiple episodes of ventricular tachycardia (VT) or ventricular fibrillation (VF) within a relatively short period of time and is associated with increased mortality and morbidity. The management of electrical storm involves a variety of strategies, including sed...
Article
Full-text available
Myxomatous disease represents the most common cause of MR due to bileaflet prolapse. Mitral valve repair of mitral regurgitation (MR) due to bileaflet prolapse poses many technical challenges. In addition, late outcomes following repair are not well characterized in this population. Published series have included mixed patient cohorts and/or lacked...
Article
Ischemic heart disease persists as the leading cause of death in the western world. The goal of cell therapy is to supply the ischemic heart with therapeutic cells that are able to restore vasculature and cardiomyocytes, or at least to an extent that improves heart function and patient quality-of-life. This chapter will discuss the potential of cel...
Article
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Purpose: The evidence supporting early surgical intervention in patients with chronic asymptomatic mitral regurgitation (MR) is steadily accumulating. Although preoperative pulmonary hypertension and left ventricular (LV) enlargement are considered when deciding on surgery, the threshold above which they influence clinical outcomes remain poorly de...
Article
Full-text available
Purpose: The functional status of patients following mitral valve repair of severe mitral regurgitation (MR) with non-ischemic cardiomyopathy is not well described. Also, the change in postoperative left ventricular function and size following correction of MR in these patients is unknown. Methods: Between 2001 and 2012, 61 patients with non-ischem...
Article
Antiplatelet therapy is critical for the management of coronary artery disease. For patients undergoing coronary artery bypass graft (CABG) surgery, controversy remains regarding the optimal postoperative antiplatelet regimen to maintain graft patency and reduce ischemic complications. With respect to on-pump CABG, considerable evidence is availabl...