M Nomura's research while affiliated with The University of Tokushima and other places

Publications (50)

Article
A body surface electrocardiograph employs 124 spot electrodes positioned wider area around human hart to detect heart potential generated by the hart beat in sync, collect and configure plural position potential signals to make up body surface electrocardiography showing human heart condition dynamically and graphically. This electrocardiography di...
Article
In the 12-lead electrocardiograph currently being used general medical practice, electrodes are positioned at 6 locations in the chest region and the cardiac potential is measured. This research increases the number of electrode to 124 at evenly-spaced intervals over the body surface of the chest, side and back. The commonly used band elimination f...
Article
We investigated whether an infarct vector, that could not be deduced from an electrocardiogram, could be detected using the isomagnetic and current density map of a magnetocardiogram. Old inferior myocardial infarctions (MI group) and normal healthy subjects (Normal group) were recorded using magnetocardiometer. The electromotive force of the heart...
Conference Paper
The present study aimed to investigate non-invasively the effects of a short-term 4 week aerobic training program on the resting common carotid artery (CCA) blood flow velocity waveforms and autonomic nervous activity in young sedentary healthy subjects. It was hypothesis that training-induced the enhancement of blood flow is associated with the im...
Article
Full-text available
Physiological blood flow velocity in common carotid artery (CCA) is altered markedly with advancing age. It is unknown that regular aerobic exercise is able to improve blood flow velocity waveforms in either healthy young or healthy older individuals. We investigate the role of regular exercise on the age-associated alterations in blood velocity wa...
Article
Background Patients with Obstructive Sleep Apnea Syndrome (OSAS) often experience gastroesophageal reflux disease (GERD).AimTo investigate gastric motility and autonomic nervous activity during sleep apnea.Methods The subjects of this study were 20 individuals with OSAS who experienced 10 or more sleep apnoea events per hour, as measured with a por...
Article
Full-text available
This report is to investigate the correlation between common carotid blood flow (CCBF) properties and the risk factors for cardiovascular disease. The measurement system was designed for simultaneously monitoring of CCBF and electrocardiogram (ECG) in order to get more valid information for detection and diagnosis of cardiovascular disease. In our...
Article
Nitrates decrease the tone of the lower oesophageal sphincter, and may thus induce gastro-oesophageal reflux. In the present study, we evaluated electrogastrographic changes and heart-rate variability before and after the administration of nitrates. In 15 patients with chest pain treated with nitrates, electrocardiography and percutaneous electroga...
Article
Mitral valve prolapse (MVP) is closely related to myocardial sympathetic nerve function. This study evaluated the presence of impaired myocardial sympathetic nerve function by Iodine-123-metaiodobenzylguanidine (MIBG) scintigraphy in ten patients with MVP. For comparison, 15 healthy subjects without heart disease were investigated (control group)....
Article
Intraoperative changes in circulatory hemodynamics and autonomic nervous activity were evaluated in 33 patients with cholelithiasis who underwent laparoscopic cholecystectomy. Of these patients, 18 were treated using a pneumoperitoneum (group G) and 15 using the abdominal wall-lifting method (group WL). Their ECG, blood pressure, arterial oxygen sa...
Article
Helicobacter pylori infection is involved in the formation of chronic peptic ulcer. However, a previously reported hypothesis concerning the involvement of central autonomic nervous disorder in this condition cannot be ruled out. To use spectrum analysis of heart rate viability to examine autonomic nervous activity before and after H. pylori eradic...
Article
Introduction QT dispersion is defined as the difference between the maximum QT and minimum QT intervals on standard 12-lead electrocardiogram (ECG). It is a new index of the homogeneity of ventricular repolarization and considered to be a marker for the risk of malignant ventricular arrhythmia [1, 2]. There have been, however, no detailed studies e...
Article
Idoxifene is a tissue-specific selective estrogen receptor modulator. Estradiol is a potent endogenous antioxidant, and nuclear factor kappaB (NF-kappaB) is a key transcription factor that induces multiple genes in response to inflammation or oxidative stress. The aim of this study was to explore the inhibitory effects of idoxifene and estradiol on...
Article
The present study was undertaken to investigate whether health-promoting activities in Japan are useful for preventing the development of lifestyle-related diseases and for promoting health. One thousand, one hundred and sixty-seven Japanese workers were given a medical health check and had their maximum oxygen uptake measured according to the tota...
Article
This study is intended to clarify the relationship between occurrence of peptic ulcer disease and dysfunction of the autonomic nervous system. We studied heart rate variability and assessed the circadian rhythm of autonomic nervous function in 20 patients with peptic ulcer (PU group) and 20 age-matched healthy controls (N group) using 24-hour Holte...
Article
Diabetes mellitus is a disease which must be controlled over the lifetime of a patient. We investigated the issues of stress and coping for diabetes mellitus which may influence self-management. In addition, we examined the association of these factors with blood glucose control, in order to review self-management instructions for diabetes mellitus...
Article
The relationship between 1/f fluctuation of the heart rate variability and Helicobacter pylori infection was evaluated, in order to clarify whether autonomic nervous dysfunction is a necessary condition for chronic peptic ulcer formation. The subjects were 11 patients with recurrent chronic peptic ulcer and 20 age-matched normal subjects. Holter EC...
Chapter
Magnetogastrograms (MGGs) using a superconducting quantum interference device (SQUID) gradiometer provides excellent temporal and spatial resolution, and are effective non-invasive tool for detecting functional disorder. It is reported that slow motility waves originate high on the greater curvature of the stomach, an area that acts as a pacemaker,...
Chapter
Since the original investigations of Lewis and Rothscnchild (1915) [1], septal activation has been thought to occur first on the Ieft septal surface and thcreafter to spread form the left side to the right side of the intraventricular septum. Thus, the initial QRS vector in electrocardiogram is considered to bedueto activation of intraventricular s...
Chapter
Biomagnetic measurement using superconducting quantum interference device (SQUID) is an effective non-invasive tool for detecting gastric function. In the present study, the weak magnetic field originating from gastric mechanical motility was detected using a newly developed high temperature (−196°C) SQUID system by liquid nitrogen.
Chapter
The magnetocardiographic three-dimensional (3-D) source localization using superconducting quantum interference device (SQUID) gradiometer has an excellent spatial and temporal resolution. Abnormal Q wave is frequently seen in the electrocardiogram (ECG) in patients with idiopathic cardiomyopathy, even in those without myocardial infarction. In the...
Article
Late ventricular potentials are widely used to predict life-threatening arrhythmias, although the predictive value is low. To improve prediction, we correlated the incidence of ventricular arrhythmias with mismatches in myocardial 99mTc-methoxyisobutylisonitrile (MIBI)/(123)I-metaiodobenzylguanidine (MIBG) accumulation and late ventricular potentia...
Article
Full-text available
A 44 year old man with Brugada syndrome and ventricular fibrillation had an autonomic disorder, shown by spectral analysis of heart rate variability and 123I-MIBG myocardial scintigraphy. Periodic variation of the ST segments was detected by Holter ECG. Increased high frequency power (0.15-0.40 Hz), an index of parasympathetic nerve activity, was o...
Article
Magnetocardiograms (MCGs) were recorded by means of a second-derivative SQUID (superconducting quantum interference device) magnetometer in 150 normal subjects (25-34 years old, 30 cases; 35-44 years old, 30 cases; 45-54 years old, 30 cases; 55-64 years old, 30 cases; 65-74 years old, 30 cases) to investigate whether cardiac current would change wi...
Article
We performed myocardial scintigraphy on a patient with ischaemic electrocardiographic changes after massive blood transfusion. Although there was no defect by 99mTc-MIBI scintigraphy, 123I-MIBG scintigraphy was observed suggesting denervation after massive blood transfusion. Myocardial scintigraphy using 99mTc-MIBI or 123I-MIBG can be useful for th...
Article
While late potentials are correlated with an increased incidence of ventricular tachycardia, they are not necessarily a good predictor of ventricular electrical instability in patients with mitral valve prolapse (MVP). Our objective was to determine whether the signal averaged electrocardiogram (SAECG) after exercise can discriminate groups with a...
Article
A 34-year-old man with cardiac murmur and without subjective symptoms was admitted to our institution. He was examined with non-invasive and invasive cardiology techniques. Ultrasonic cardiography (UCG) showed asymmetric septal hypertrophy (ASH) and systolic anterior movement (SAM) of the mitral valve. Left ventriculography (LVG) showed hypertrophy...
Article
A 90-year old patient with an atrial septal defect (ASD) and sinus rhythm, but no history of atrial fibrillation of heart failure is presented. Literature searches revealed no similar report of such a case. In addition, this patient represents the oldest documented patients with ASD associated and sinus rhythm.
Article
Mitral valve prolapse (MVP) is closely related to myocardial sympathetic nerve function. This study evaluated the presence of impaired myocardial sympathetic nerve function by Iodine-123-metaiodobenzylguanidine (MIBG) scintigraphy in nine patients with MVP. For comparison, 15 healthy subjects without heart disease were investigated (control group)....
Article
We recorded the signal-averaged electrocardiography (SAECG) of patients with diabetic retinopathy in order to clarify whether a ventricular conduction disturbance can be detected by time- or frequency-domain analysis of the SAECG. Twenty-four normal subjects (N group) and 20 patients with diabetic retinopathy [diabetes mellitus (DM) group] were stu...
Article
Right chest electrocardiograms (ECGs) of 75 healthy subjects (19 men and 56 women; age 18 to 25 years) were recorded in order to study characteristic features of right precordial ST-T and QRS waves. The diagnostic criteria for right ventricular infarction (RVI) by ECG were also tested in healthy subjects to reascertain their value for diagnosing RV...
Article
The usefulness of magnetocardiography (MCG) in determining the location of an accessory pathway (Kent bundle) was examined by the isomagnetic map at the time of a delta wave, and by gated magnetic resonance imaging (MRI). MCG was performed at 36 points on the anterior chest wall in eight cases with Wolff-Parkinson-White (WPW) syndrome using a SQUID...
Article
Isomagnetic maps of 50 normal subjects (control group) and 23 patients with old inferior myocardial infarction (IMI group) were recorded in order to analyse T wave abnormalities in inferior myocardial infarction. The T wave of the magnetocardiogram (MCG) in the control group showed negative deflections in the left upper portion and positive deflect...
Article
The T wave changes in left ventricular hypertrophy and old inferior wall myocardial infarction were studied by the isomagnetic map to compare with those in the isopotential map. The isomagnetic map could detect the instantaneous current source, and the abnormal repolarization vector was more frequently observed in the isomagnetic map than in the is...
Chapter
Steady effort on research of the magnetocardiogram (MCG) has been made since the introduction of SQUID gradiometer to measure weak magnetic field of the heart. 1,2 The isomagnetic map was useful to study instantaneous magnetic field of each phase of cardiac cycle like the isopotential map. However, compared with the isopotential map, few studies on...
Article
The isomagnetic maps of normal subjects and patients with right and left atrial overloading were recorded to determine the characteristic features of the magnetic field of atrial depolarization. The isomagnetic maps examined in this study indicated the instantaneous current source, which specifically localizes the current sources due to the right a...

Citations

... More recently the dissolution of pills was also studied with a 83 channel SQUID system [10]. A 16 channel high Tc SQUID magnetometer placed inside a small shielded enclosure was used to study stomach motility, by recording fields produced by a 1.3 mm diameter steel ball placed at the antrum [11]. ...
... It is important to accurately measure and simulate MFs generated from GEA as they are known to be weak in nature (Allescher et al 1998, Bradshaw et al 2007, 2009, Richards et al 1996, Saijyo et al 1995. In addition, only the MFs in the direction normal to the coronal plane are typically measured experimentally, and the simulation results have shown that the MFs in this direction are generally much smaller than those in the other two directions (Komuro et al 2008). ...
... To resolve the problems cited above, the authors (and associates) developed a high-resolution body-surface electrocardiograph system (Inui et al. 2010;Inui et al. 2007). Primary features of the system are described below. ...
... In several studies, flow velocity in carotid artery were characterized into five feature points [19,32,33] , as is depicted in Fig. 3 . The first peak systolic velocity wave is peak velocity S1 . ...
... All four subunits have been identified in cardiac and skeletal muscle [63,[71][72][73]. Similarly, variable expression of K ATP subtypes has been demonstrated in different vascular beds [68,[74][75][76][77][78][79][80], although low-conductance channels encoded by Kir6.1 may represent the predominant K ATP channel subtype in vascular smooth muscle [81]. ...
... Increased repolarization heterogeneity of the diseased heart can be either anatomic, due to infarction, fibrosis, or structural remodeling, or electrophysiological, due to ischemia, electrical remodeling, drugs, genetic defects or heterogeneous autonomic innervations. 35 Many MCG studies have attempted to investigate the repolarization abnormalities in subjects with myocardial infarction, [36][37][38][39] acute chest pain, 7-12 stable CAD after stress [40][41][42] or only at rest. [13][14][15][16][17][18][19][20] The diagnostic accuracy for MCG has been reported to be similar to the efficacy of those of existing noninvasive modalities for diagnosing CAD, 21,22 whereas limited in head-to-head comparison with stress MPI. ...
... In the current study, the most common form of QRS wave that was observed on the V3R lead was rS and the frequency corresponded to 41.5%; this was followed by rs (39.2%) and rsr' (8.5%). These results were discrepant (81.0% and 89.0%, as reported by Tan et al. 11) and Saito et al. 12) ). This discrepancy was attributed to the rS type subdivided into rs, rS, Rs, and RS types in the current study, unlike the studies by Tan et al. 11) and Saito et al. 12) If the sub-type classification was combined as the rS type, the total frequency would have lead also showed that the rs type occurred in 60.0% and this type accounted for most of the cases; this was followed by rS (14.6%) and rsr' (10.8%). ...
... Thus, it might not be detected until the individuals are elderly. 2) The patient was a 101-year-old woman with an ASD of the ostium secundum type (left to right shunt). The present report was made because the patient could be the oldest individual with ASD among those reported to date. ...
... Recently, non-invasive imaging of sympathetic innervation of the myocardium using PET [1][2][3][4][5] or SPECT [6][7][8] has gained interest based on its ability to predict life-threatening ventricular arrhythmias [9][10][11] and to assess whether implantable cardioverter defibrillator (ICD) therapy is appropriate [12,13]. It has been shown that sympathetic nerve terminals in the myocardium are more sensitive to ischemic damage than cardiomyocytes [9,[14][15][16][17][18][19][20][21]. ...
... In 1998, two case reports were published, describing the cases of two middle aged men with Brugada syndrome who underwent MIBG scintigraphy, to evaluate myocardial autonomic innervation. Nomura et al. observed a decreased accumulation or an unequal distribution of [ 123 I]MIBG in part of the inferior wall, the apex and anterior wall of the left ventricle as well as an increased wash out in the inferior wall [66]. Similarly, Agostini et al. found defects of myocardial neuronal MIBG uptake on MIBG SPECT imaging in inferior, apical and septal walls [67]. ...