M. Manca's research while affiliated with Maastricht University and other places

Publications (24)

Book
Full-text available
The debate over eHealth is alive as never before. Supporters suggest that it will result in dramatic innovations in healthcare, including a giant leap towards patient-centered care, new opportunities to improve effectiveness, and enhanced wellness and quality of life. In addition, the growing market value of investments in health IT suggests that e...
Article
Recent evidences suggest that modulation of vascular structure by matrix metalloproteinases (MMPs) could be a main determinant of acute cardiovascular events in high-risk subjects. The authors consecutively selected 46 subjects affected by familial combined hyperlipidemia (FCH), 44 by metabolic syndrome (MS), 44 by FCH and MS, and 40 healthy subjec...
Article
Full-text available
Epidemiological data from the Framingham and other prospective studies suggests an inverse correlation between the plasma concentration of HDL-cholesterol (HDL-C) and the incidence of cardiovascular disease. The relationship between HDL-C and its vascular-protective effects is particularly due to the heterogeneity of these particles and their impor...
Article
In the setting of a six-month, open-label clinical trial, 141 consecutively enrolled, hypertensive, overweight patients were randomized to the oral ingestion of psyllium powder or guar gum 3.5 gr t.i.d., to be taken 20 min before the main two meals, or to standard diet. Both fibers improved significantly BMI, FPG, FPI, HOMA Index, HbA1c, LDL-C, and...
Article
Objective: Familial Combined Hyperlipoproteinemic (FCH) is a disorder of lipid metabolism characterized by an increased risk of premature coronary heart disease. Our aim is to estimate the prevalence of FCH subjects in a large North-Italian rural population monitored for 32 years (1972-2004). Methods: In the 2004 Brisighella Heart Study (BHS) surve...
Chapter
Historically, renal dysfunction has been considered separately from the cardiovascular risk profile, and has been treated as such. In particular, cardiologists, concerned with treating the heart and vasculature, did not routinely consider the impact of disturbed renal function on the progression toward cardiac events. However, the landscape of card...
Article
Over the last few decades, evidence on the beneficial effects of physical activity on health has been accumulating, and public health awareness has increased about the tangible benefits of promoting active habits among the general population.

Citations

... Suitable physical activity is believed to be bene cial to cardiovascular health and can reduce all-cause mortality 32,33 . Sedentary women and overweight children can bene t from increased physical activity 34,35 . ...
... Traditionally, the delivery of healthcare services depended on offline files and paper-based records, which led to many discrepancies and inefficiencies (Gaddi, Capello and Manca, 2013). This was later changed and improved through the implementation of e-Health. ...
... Therefore, an understanding of the determinants of HDL-C concentrations is timely. Considerable variability in HDL-C concentrations exists within population groups (3,5) . Heritability estimates for HDL-C concentrations range between 40 and 60 %. ...
... As shown in Figure 1, the selection process is visualized in the PRISMA flow diagram. The electronic search yielded a total of 4375 studies, of which 53 (acute effect, 18; training effect, 21; habituated effect, 14) were included. After the removal of duplicates, 1842 studies were manually reviewed. ...
... hypercholesterolemia with hypertriglyceridemia [8]. Hypertriglyceridemia per se seems in fact to be a significant predictor of cardiovascular disease in proportion to the baseline TG levels [9] . Familial combined hyperlipoproteinemia is one of the most common genetic hyperlipoproteinemias in the general population (estimated prevalence: 0.5-2.0%) [10], and the most frequent one in early acute myocardial infarction survivors (11.3%) [11] and overall in myocardial infarction survivors (up to 40%) [12]. The metabolic syndrome (MS) is also very frequent , ranging from 20% to 40% in the adult general population, and it is strongly linked to increased cardiovascular disease risk [13]. The ...
... These studies were conducted in the UK [20], the USA [21], and Taiwan [22]. We also identified three eligible trials involving 230 participants with CVD [23][24][25], and 9 trials involving 648 participants with hypertension [26][27][28][29][30][31][32][33][34]. The increase in fibre intake ranged between 5.6 and 12 g per day. ...
... MMPs may also be involved in obesity promotion [9,25,26]. Few studies have suggested that the imbalanced level of MMPs and their inhibitors may be playing an important role in the cardiovascular events associated with metabolic syndrome and reported major changes of MMPs levels in patients with metabolic syndrome [27,28]. Although several studies have examined the associations between polymorphisms in the VEGF gene and metabolic syndrome [15,29] but the association of VEGF +405 C/G gene (rs2010963) polymorphism and cardio-metabolic risk factors and MMP-3 in patients with metabolic syndrome has not been evaluated yet. ...