M Magarici’s research while affiliated with Centro Médico de Caracas and other places

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Publications (3)


Figure 1. Examples of amputation rates (%) of diabetic foot patients. 
Table 1 . Examples of diabetic foot ulcer prevalence by country and reference
Clinical Outcomes of Diabetic Foot Management with Circulat
  • Article
  • Full-text available

October 2008

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248 Reads

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4 Citations

Phytotherapy Research

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M Magarici

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F Amendola

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[...]

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A Muhammad

Major and minor lower-extremity amputation is a common complication among diabetics. Various sources indicate diabetic foot ulcer prevalence at between 2.2% and 15% in diabetics. This study evaluates the efficacy and tolerance of a standardized plant extract combination, Circulat, developed for the prevention and treatment of severe manifestations of type 2 diabetes, such as necrotic damage of the foot. Thus, a retrospective cohort study was carried out in 174 patients treated with Circulat with diabetic foot grades D1-D3, according to The University of Texas Wound Classification System, in 50 medical centers, from 2004 to 2007. Circulat obtained 50.57% complete cure of diabetic foot, significant improvement in 37.9% and prevented amputation in 88.5% of the study's total population. The treatment was well tolerated. Four patients (2.3%) had slight gastrointestinal unrest which did not warrant suspension of treatment.

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Analysis of effects of the herbal preparation Circulat on gene expression levels in cultured human fibroblasts

August 2007

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121 Reads

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7 Citations

Phytotherapy Research

Circulat is a systemic standardized plant extract formulation that was developed for the prevention of severe manifestations of type 2 diabetes such as necrotic damage of the plantar foot. With the aim of revealing the molecular mechanisms underlying Circulat's biological activity, the effects of Circulat treatment on gene expression levels were examined in the cultured human fibroblast cell line MRC-5 using Affymetrix oligonucleotide microarrays. The analysis identified 187 genes, the expression levels of which underwent significant changes upon Circulat treatment. These include four genes (IL6, HMGA1, SLC19A2 and C4A) that have been implicated previously in the development of diabetes. A large proportion of the identified genes are involved in energy metabolism, protein synthesis, glucose metabolism and signaling pathways. Synergistic action of the Circulat components has also been revealed. Prospective applications of microarray analysis in phytopharmacology are discussed.


The Systemic Theory of Living Systems. Part IV: Systemic Medicine—The Praxis

January 2006

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398 Reads

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26 Citations

Evidence-based Complementary and Alternative Medicine

This fourth lecture illustrates the praxis and results of Systemic Medicine (SM) in various therapeutic applications. SM's success has made it popular throughout Venezuela and Puerto Rico. The treatment of over 300,000 patients by 150 orthodox MD's, trained and qualified in SM, in 35 medical establishments with above average results corroborate its effectiveness as an eCAM in chronic degenerative diseases. Herein we provide a synopsis of results obtained in four such pathologies-the journal's necessary space restrictions somewhat limiting content-as well as clinical and photographic evidence. The validity of any medical theory is substantiated by its degree of effectivity and success. The workability of evidence-based SM corroborates Systemic Theory's transcendence.

Citations (3)


... Authors sometimes turn to the concepts of thermodynamics, believing that the systems theory "establishes the cause of all diseases as an increase in entropy" [16]. However, systems theory is only a tool that, by definition, cannot establish anything. ...

Reference:

On the Way to the Medicine of Quantum-dimensional Processes
The Systemic Theory of Living Systems. Part IV: Systemic Medicine—The Praxis

Evidence-based Complementary and Alternative Medicine

... Following Affymetrix oligonucleotide microarrays analysis, among 187 genes identified on the human fibroblast cell line MRC-5, interleukin 6, HMGA1, SLC19A2 & C4A have been associated with the development of diabetes. 2 In the second period, scientists strove into developing bioinformatics approaches to discover new targets from the molecular network modulated following treatment with their herbal medicine formula. For example, Si Wu Tang formula, composed of four herbs, has been recognized for treating gynecological diseases. ...

Analysis of effects of the herbal preparation Circulat on gene expression levels in cultured human fibroblasts
  • Citing Article
  • August 2007

Phytotherapy Research

... Eleutherococcus senticosus has the capacity to increase cellular ATP levels. (76) So, we hypothesized that the increase in locomotive activity caused by KPG-7 is due to higher ATP levels. However, the worms treated with KPG-7 showed low levels of cellular ATP at 3 days of age (Fig. 6). ...

Clinical Outcomes of Diabetic Foot Management with Circulat

Phytotherapy Research