M Kakimoto's research while affiliated with Okayama University and other places

Publications (7)

Article
The effects of Fujibitol, a preparation of crude drugs in wide clinical use for treatment of chronic rhinitis and empyema, on experimental allergic rhinitis in rats were studied. Fujibitol inhibited nasal allergic symptoms, i.e. sneezing and nasal rubbing, induced by antigen in sensitized animals. An increase in dye leakage into the nasal cavity in...
Article
The effects of Fujibitol, a remedy for the nasal symptoms of immediate and delayed type allergic reactions were studied. Fujibitol inhibited active systemic anaphylaxis in mice, heterologous passive cutaneous anaphylaxis (PCA) in rats, Masugi's nephritis in rats and delayed type hypersensitivity induced by picryl chloride in mice, but did not affec...
Article
We found that Aged Garlic Extract (AGE) could be a significant immuno-potentiator, and could exhibit anti-tumor activities through immune modulation. Consequently, AGE stimulated the proliferation of mouse spleen cells and the release of cytokines, such as IL-2, TNF-alpha and IFN-gamma, increased NK activities, and enhanced phagocytosis of peritone...
Article
To examine the effect of Aged Garlic Extract (AGE) on the function of mast cells and activated T lymphocytes, we adopted the in vitro histamine release system, the in vivo IgE mediated skin reaction system and the in vivo late phase reaction system. Consequently, at 1.25, 2.5, and 5.0% (v/v), AGE dose-dependantly inhibited the antigen specific hist...
Article
The effect of several kinds of garlic preparations such as raw garlic juice (RGJ), heated garlic juice (HGJ), processed garlic powder (PGP) and aged garlic extract (AGE) on both physiological and psychological stress were investigated using four stress models in mice: forced swimming test, mechanical treadmill running, immobilization stress test, a...
Article
Abstruct — A study was made on the effect of HK302 (freeze-dried powder of ethanol extract from roasted Panax Notoginseng) on the animal models for acute inflammation. Oral admi-nistration of HK302 (2000mg/kg) inhibited slightly rat paw edema induced by carrageenin, but did not inhibit increasing vascular permeability in the mouse peritoneal cavity...

Citations

... Garlic (Allium sativumLinn.) is a perennial herb that belongs to the Family: Lilliaceae. Garlic like many traditional medicinal plants has a wide range of utility to treat health issues including atherosclerosis, cardiovascular diseases, hyperlipidemia, diabetes, hypertension and thrombosis [13]. The dried bulbs of garlic are frequently incorporated as condiment/spice in different food items in many countries including India. ...
... Garlic contains about 33 sulfur compounds like alliin, allicin, ajoene, allyl propyl and etc. Allium species have immune-enhancing activities like promotion of lymphocyte synthesis, cytokine release, phagocytosis and natural killer cell activity (Kyo et al., 1998). Garlic has an immune raising activity that involves the promotion of lymphocyte formation, cytokines release, phagocytosis and natural killer cells activity (Kyo et al., 1998). ...
... Ghanzafari et al., (2002) had earlier reported increased delayed type hypersensitivity reaction in mice supplemented with garlic while Oladele and Bakare (2011) reported increased antibody response to ND vaccination. The present study agrees with these earlier reports and confirms the previous reports on the immunostimulating effect of garlic (Kyo et al., 1997). T-helper 2 cells, a subset of T-cells, is involved with the clonal expansion of B-cells for production of antibody (Abul et. ...