M H Panh's research while affiliated with PX'Therapeutics, SA, Grenoble, France and other places

Publications (23)

Article
A case of primary intracerebral granular-cell tumor is described in a 64-year-old woman. The originality of this study is due to the histological and histochemical evidence of its astrocytic origin. The authors also include a literature review with clinical, pathological and histological comments about this tumor.
Article
The immunohistochemical localization of the glial fibrillary acidic (GFA) protein was studied on 32 human intracranial neoplasms and in 1 experimental glioma. Biopsy and/or autopsy material was fixed in formaldehyde or in formaldehyde-glutaraldehyde and embedded in paraffin or in epon. Positive reaction to GFA protein antibody has been demonstrated...
Article
Thirty-two cases of human central nervous tumor and one experimental glioma were studied in fixed paraffin or epon embedded tissues using the peroxidase-antiperoxidase method. The present study confirms the usefulness of immunohistochemical methods for the diagnostic evaluation of neuro-epithelial neoplasms. The authors also include some prognostic...
Article
A mediastinal and intraspinal collar-stud tumour in a 77 year-old-woman is reported. The orginality of this study comes from the histologic findings of a combined neurilemmoma and angioma. The authors also include a brief review of literature and clinicopathological and histogenetic comments, about these combined tumours.
Article
A case of intracerebral granular cell tumor is described in a 64 year-old woman. The originality of this study comes from the histological and histochemical evidence of its astrocytic origin. The authors also include clinical, pathological and histogenetic comments about this tumor.
Article
Two cases of intracranial gliomas with extraneural metastases are described. Case 1, studied with biopsy material only, was a left malignant astrocytoma from the area of the rolandic fissure with right cervical lymph nodes metastases in a 43-year-old man. Case 2 was a left temporal malignant astrocytoma in a 21-year-old woman. Fifteen days after cr...
Article
This paper describes the first French case of lymphomatoid granulomatosis (LYG) in 46-year-old male. Autopsy revealed bilateral pulmonary involvement and multiple central nervous system (CNS) localizations. The originality of this study is due to 1st the scarcity of reported cases of LYG in Europe 2nd a detailed neuropathological study permitting d...
Article
The authors report a clinical and pathological case of carcinoïd heart disease in a 70-years old man. The primary carcinoïd tumor was ileal with both hepatic and neighbouring lymph node metastases. The clinical history was dominated by a typical carcinoïd syndrom biologically confirmed and accompanied by a tricuspid insufficiency. An autopsy permit...
Article
A case of lymphomatoid granulomatosis is described in a 46 year old man. Autopsy confirmed pulmonary and central nervous system involvement. Some clinical, pathological and nosological comments are considered.
Article
Anatomical and clinical findings in 9 cases of primary brain tumors with metastases within (7 cases) or outside of (2 cases) the nervous system are reported. A review of the published literature revealed 248 cases of histologically-confirmed central nervous system tumors with metastases outside of the nervous system. These secondary sites are seen...
Article
A new anatomo-clinical case of vertebro-basilar dissecting aneurysm in a 43 year old woman is reported. The originality of this study comes from the autopsic discovery of an intimal fibro-dysplasia at the origin of the dissection in the left vertebral artery. The authors also included anatomoclinical and pathogenic comments about both the lesions d...
Article
Extraneural metastases of central nervous system tumours are very rare (248 of histologically proven examples in the literature). They are mainly in adult males and in the following descending order of frequency: gliomas (39.5%), meningeal tumours and sarcomas (28.2%), neuronal tumours (14.1%), lymphomas-microgliomas (12.5%), pineal tumours (4%) an...
Article
A case of sarcoma arising in a left temporal oligodendroglioma is described in a 39-year-old male. The postoperative evolution was marked by a paraplegia linked to medullary and subarachnoid metastases. Then a relapse of the cerebral tumor occurred, and the patient died 6 months after the onset of the symptoms. Histologically, the mesenchymal compo...
Article
A case of primary intracranial melanoma in a 65-year-old female is described. A complete postmortem examination revealed multiple metastases in the liver, and eliminated the possibility of an extraneural primary melanoma. A review of the literature confirmed that such cases are highly exceptional, and that an exhaustive autopsy including particular...
Article
The authors report an anatomo-clinical case involving a colloid cyst of the 3rd ventricle diagnosed at the autopsy on a man of 20. The originality of this case arises from the simultaneous discovery of a capillary hemangioma of the choroid plexus of the left pontocerebellar angle and of the leptomeninges of the adjacent cerebellum. This exceptional...
Article
The authors report the first two French cases of primary rabdomyosarcoma of the central nervous system. They then review the literature on muscle tumours or primary myosarcomas of the nervous system of which 29 cases have now been published. From the point of view of morphology and classification, one should distinguish firstly, purely mesenchymato...
Article
The authors report the pathological and clinical findings of a dissecting aneursym of the basilar artery in a 32 year old man up till then in good health, who died two months later. The pathological study showed bilateral lesions of osteo-malacia in the neighborhood of the pons due to hemo-dissection affecting the right vertebral artery just before...
Article
Two cases of extra-articular synovial sarcoma are reported together with a review of the literature. The analysis of 44 cases shows that this tumor appears among young people particularly between 10 and 30 years of age and is twice more frequent among males. There can be metastasis mostly in lungs (11 times), which can sometimes appear much later (...

Citations

... Intracranial melanomas most commonly occur at the temporal lobe (20%), cerebellum (25%), or cerebellopontine angle (15%). Occipital lobe lesions are only 2% of all 19) . ...
... Metastasis is the major cause of cancer-associated mortality, causing >90% of fatalities of carcinoma patients, and EMT promotes the metastasis ability of cancer cells for most carcinomas. Multiple reasons have been suggested for the low incidence of extracranial metastasis of GBM, including inhibition of extracranial growth of glioblastoma cells through the immune system (34), the blood-brain barrier (35), short survival periods (36) or the absence of lymphatic channels in the central nervous system (37), and a previous report indicated extracranial metastases after organ transplantation from GBM donors (38). In the present study, it was demonstrated that the transcription factor FOXK1 takes part in regulating the EMT. ...
... Several case reports from the morphologic era confirmed such so-called "oligodendroglioma-sarcomas" that developed from oligodendrogliomas. It was speculated that the sarcoma component of these tumors were malignant transformed endothelia or perivascular fibroblasts induced secondary to oligodendroglioma [1,16,27]. Later case reports also included information on the 1p/19q and sometimes even the IDH status of such tumors, which were then mostly referred to as "oligosarcomas" [19,34,38,41,42]. The WHO classification describes sarcomatous areas as a rare pattern in grade 3 oligodendrogliomas [23]. ...
... Voellger et al. [10] found an unfavorable impact of age > 70 years at the time of diagnosis on survival, which was significant at 12 months after diagnosis. 20 Geddes et al. [32] 65/M P Bx RT -+ 4 21 Geddes et al. [32] 66/F Fr Bx RT -+ 9 22 Geddes et al. [32] 64/M P-O NA RT -+ 8 23 Geddes et al. [32] 55/F T-P TR RT -+ 8 24 Chorny et al. [33] 78/F Fr-P STR RT + chemotherapy +/-+ 7 25 Chorny et al. [33] 83/F P Bx RT -+ 2 26 Chorny et al. [33] 66/F P STR RT + chemotherapy -+ 25 27 Brat et al. [ The reason for this poor outcome remains unclear, especially in those cases characterized by low proliferative activity and absence of mitotic activity. ...
... This result is linked to the "vascular instability" that is caused by higher levels of matrix metalloproteinase-2 and -9, which are hypothesized to be induced by tumor cytokines. The aberrant arteries are prone to thrombosis and bleeding [16,70]. ...
... Bardzo rzadkie umiejscowienie obejmuje trzustkę, śledzionę, jelito cienkie, przyusznice, skórę, a nawet serce i szpik kostny [4,54,56,57,58,59,70]. Wśród zajętych kości najczęściej opisywano kręgi, chociaż ogniska przerzutowe znajdowano również w żebrach, mostku, łopatce, czy panewce kości biodrowej [71,72]. Przerzuty do kości mają zwykle charakter izolowany lub ograniczony, jakkolwiek obserwowano również zmiany mnogie. ...
... Unlike most systemic cancers in other organs with high frequency of brain metastasis, the systemic extraneural metastasis (ENM) of glioblastoma was rare (0.4%-0.5% of all cases) possibly due to strong barriers formed by the dura mater and blood-brain barrier (BBB) (1,2). However, in a systemic review for the published ENM cases, Pietschmann et al. reported a remarkable increase in the number of reported cases per decade over time (3). ...