M.-A. Janmohammadi’s scientific contributions

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Publications (1)

Figure 2. Antinociceptive effect of different doses of midazolam in the tail-flick test. Mice were injected intraperitoneally (IP) with saline (5 mL/kg) or midazolam (0.3, 0.3, 3, or 6 mg/kg). Antinociception was recorded for 60 min after midazolam administration. Each point is the mean ± SEM of %MPE for seven mice. ** p < 0.01, ***p < 0. 001 vs saline.
Figure 3. Antinociceptive effect of different doses of morphine in the presence or absence of lower dose of midazolam in the tail-flick test. Mice were injected with saline (5 mL/kg IP) or midazolam (4 mg/kg IP) 5 min before administration of morphine (3, 6, 9, or 6 mg/kg SC). Antinociception was recorded for 60 min after morphine administration. Each point is the mean ± SEM of %MPE for seven mice.
Figure 4. Antinociceptive effect of different doses of morphine in the presence or absence of higher dose of midazolam in the tail-flick test. Mice were injected with saline (5 mL/kg IP) or midazolam (0.03 mg/kg IP) 5 min before administration of morphine (1, 2, 3, or 6 mg/kg SC). Antinociception was recorded for 60 min after morphine administration. Each point is the mean ± SEM of %MPE for 7 mice. *p < 0.05 vs saline.
Figure 5. Change in antinociceptive effect of morphine, midazolam, or morphine plus midazolam due to flumazenil injection 15 min before midazolam (6 mg/kg or saline IP) or 20 min prior to morphine (4 mg/kg or saline IP) administration. Antinociception was recorded for 60 min after morphine/midazolam administration. Each point is the mean ± SEM of %MPE for seven mice. *p < 0.05, **p < 0.001, ***p < 0.01 vs saline.
Figure 6. Effect of naloxone on antinociceptive effect of morphine, midazolam, or morphine plus midazolam. Naloxone was injected 15 min before midazolam (6 mg/kg or saline IP) or 20 min prior to morphine (4 mg/kg or saline SC) administration. Antinociception was recorded for 60 min after morphine administration. Each point is the mean ± SEM of %MPE for seven mice. **p < 0.01, ***p < 0.001 vs saline.
Midazolam-induced antinociception: Possible interaction with morphine response in tail-flick test
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April 2003

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59 Reads

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1 Citation

Archives of Iranian Medicine

Hossein Rastegar

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M.-A. Janmohammadi

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M.-R. Zarrindast

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[...]

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Background - Benzodiazepines have been used with opiates to give better pain relief than opiates alone. However, the interaction between the two groups of drugs is controversial. The aim of this study was to investigate whether midazolam potentiated the antinociceptive effect of morphine. Methods - Male albino mice were used in this study. Antinociception was measured using the tail-flick test. Results - Midazolam and morphine caused dose-dependent antinociceptive effects in mice. The combination of midazolam and morphine showed an increase in analgesia. The benzodiazepine receptor antagonist, flumazenil, decreased the response induced by midazolam or midazolam plus morphine but not that of morphine alone. However, the opioid receptor antagonist naloxone, reduced the antinociception induced by morphine, midazolam, or a combination of the two drugs. Methysergide or propranolol increased the analgesic effect of midazolam; ketanserin, phenoxybenzamine and atropine did not. Conclusion - Midazolam induced antinociception through both benzodiazepine and opioid receptors.

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