Lyn Y. Abramson's research while affiliated with University of Wisconsin–Madison and other places

Publications (287)

Article
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Background Residence in high-crime neighborhoods, especially in childhood, is linked to mental health issues later. Detecting distinct neurobiological processes underlying the effects of this environmental stressor may be critical to identify prevention and intervention targets. This study examined the relationships of levels of a circulating infla...
Article
The reward-hypersensitivity model posits that trait reward hypersensitivity should elicit hyper/hypo-approach motivation following exposure to recent life events that activate (goal striving and goal attainment) or deactivate (goal failure) the reward system, respectively. To test these hypotheses, we had 87 young adults with high trait reward (HRe...
Article
Background Negative inferential style, rumination and attention are cognitive vulnerabilities implicated in depression that first emerge in childhood and adolescence. Methods The current study used a prospective longitudinal design to examine whether rumination mediates the relationship between attention (selective attention, sustained attention,...
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Negative inferential style is a cognitive vulnerability for depression. Yet, few studies have explored how this risk factor intersects with culturally-specific protective factors, such as racial identity, in a unified cognitive risk-cultural asset model in youth of color. The current study addressed this gap by exploring the interplay between negat...
Preprint
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Most research testing the association between inflammation and health outcomes (e.g., heart disease, diabetes, depression) has focused on individual proteins; however, some studies have used summed composites of inflammatory markers without first investigating dimensionality. Using two different samples (MIDUS-2: N = 1,255 adults, MIDUS-R: N = 863...
Poster
A comparison of empirically-identified structures of inflammatory variables to an "a priori" unidimensional aggregate seen in the literature. The presentation will be on 4/29/21 at 1:15-2:15 PM EST and 7-8 PM EST. Join the zoom link in the SOBP portal to join!
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Chronic, systemic inflammation is implicated in physical and mental health; little is known about whether sex and racial differences detected in adulthood are observed during adolescence or about normative changes occurring during adolescence. This longitudinal, United States-based study examined four biomarkers of systemic inflammation [C-reactive...
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The mechanisms of the well-documented relationship between maternal depression and offspring psychopathology are not yet fully understood. Building upon cognitive theories of depression and the modeling hypothesis, path analyses tested whether maternal depression history predicted adolescent internalizing symptoms via the transmission of cognitive...
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Individual differences in the timing and tempo of pubertal development have been shown to be related to depressive symptoms during adolescence, particularly among girls. Another measure of variability in pubertal development is pubertal synchrony, the degree to which the development of pubertal indicators (e.g., breast growth and ancillary hair gro...
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Inflammation is gaining support as a biological mediator between stress and many negative outcomes that have heightened risk during adolescence (e.g., mood disorders). Thus, an important line of inquiry is evaluating whether risk factors for mood psychopathology also are associated with heightened inflammatory responses to stress during this develo...
Preprint
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Background: Response styles theory is a well-supported etiological theory of internalizing psychopathology. However, evidence indicates that the three response styles (rumination, problem-solving, and distraction) are not orthogonal, highlighting the importance of multivariate tests of this theory. Further, different types of symptoms within a diso...
Presentation
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In "The Neuroimmunology of Depression: Beyond Diagnoses" chaired by myself and Carmine Pariante. Recording: https://www.youtube.com/watch?v=xHSIJUW8E98&list=PL9oMEuQcUyCzoe2p5pyQqBed2SrnyYCe6&index=6&t=0s
Article
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Low socioeconomic status (SES) may be associated with earlier pubertal timing and impaired attention and executive function (EF) in youth; however, whether pubertal timing mediates the relation between SES and attention or executive functioning remains unclear. Structural equation models tested concurrent and prospective relations between SES, pube...
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A better understanding of the maturational correlates of inflammatory activity during adolescence is needed to more appropriately study both normal and abnormal development. Inflammation is the immune system’s first response to infection, injury, or psychological stress, and it has been shown to be elevated in individuals with both physical and psy...
Poster
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This project is published at the Journal of Youth and Adolescence (https://link.springer.com/article/10.1007%2Fs10964-020-01216-y). A postprint is also available on Researchgate. Both reward sensitivity and cognitive response styles are associated with heightened inflammatory physiology. Consistent with the immunocognitive model of mood disorders,...
Article
This research was supported by National Institute of Mental Health Grants MH079369 and MH101168 awarded to Lauren Alloy, National Institute of Mental Health Grant MH096478 awarded to Lauren Ellman and National Research Service Awards F31MH118808 to Naoise Mac Giollabhui.
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There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This study separates predictors into between-person and within-person components in an attempt to gain greater clarity about this relationship. Blood samples were collected and depressive symptoms...
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Depression increases dramatically during adolescence. This finding has been demonstrated using multiple measures, including the Children’s Depression Inventory (CDI). The CDI is one of the most commonly used measures to assess depression in youth. However, there is little agreement on its factor structure, and it is possible that its factor structu...
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Living in high crime areas and rumination each have been identified as risk factors for depression among youth, yet it is unclear how crime and rumination may synergistically increase the risk of adolescent depression. Adolescents (N = 309; 51% female, Mage= 12.9, SD = 0.61) completed self-report measures of rumination, depressive symptoms, and pro...
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Background: Cognitive vulnerability theories of depression outline multiple, distinct inferential biases constitutive of cognitive vulnerability to depression. These include attributing negative events to internal, stable, and global factors, assuming that negative events will lead to further negative consequences, and inferring that negative even...
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Background There is substantial evidence that many depressed individuals experience impaired executive functioning. Understanding the causes of executive dysfunction in depression is clinically important because cognitive impairment is a substantial contributor to functional impairment. This study investigated whether elevated levels of an inflamma...
Presentation
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The spiritual successor of this project, "Inflammatory Phenotype of Depression Symptom Structure: A Network Perspective" has been accepted for publication at Brain, Behavior, and Immunity. Please see the corresponding ResearchGate page. A comparison of depression and anxiety symptom networks in individuals with elevated vs. non-elevated CRP.
Article
Off-time pubertal development is a predictor of substance use among adolescents. Early-maturing girls and early- and late-maturing boys appear to be at greater risk for substance use, although findings are more consistent for girls. Although cognitive factors are also important in the etiology of adolescent substance use, few studies have investiga...
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Research in developmental psychology highlights youth’s self-schemas as one possible pathway to improve adolescents’ functioning and promote positive developmental outcomes. Despite this, the trajectory of positive and negative self-schemas is relatively understudied. This study addresses this limitation by empirically examining the trajectory of s...
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Inflammation has been implicated in depressive symptoms, but few studies use longitudinal designs with adolescents. Furthermore, the extant literature has yielded inconsistent results. Blood was collected from a community sample of 201 adolescents (109 female, ages 12.3-20.0) and analyzed for inflammatory proteins. Up to five follow-up assessments...
Article
This study investigated whether longitudinal changes in inflammatory physiology moderated the relationship between recent stressful life events and subsequent depressive symptoms in adolescence. A diverse sample of adolescents representative of an urban community (N = 129; Age at baseline = 12.5 years; 48.8% female; 55.0% African American) complete...
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Whether cognitive vulnerability to depression exists along a continuum of severity or as a qualitatively discrete phenomenological entity has direct bearing on theoretical formulations of risk for depression and clinical risk assessment. This question is of particular relevance to adolescence, given that cognitive vulnerability appears to coalesce...
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Adolescence is a period of human development associated with increased emotional intensity and heightened vulnerability to developing psychopathology. This study used Latent Class Analysis to identify subgroups of youth based on emotional clarity and cognitive response styles. Participants were 436 adolescents (51.8% female; 48.2% African-American/...
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There is evidence that anxiety precedes the onset of depression and that rumination contributes to this risk pathway in adolescence. This study examined inflammatory biomarkers as mediators in a risk model of depressive symptoms secondary to anxiety symptoms among adolescents who ruminate. A sample of 140 adolescents (52% female, 54% African Americ...
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Hopelessness is implicated in multiple psychological disorders. Little is known, however, about the trajectory of hopelessness during adolescence or how emergent future orientation may influence its trajectory. Parallel process latent growth curve modelling tested whether (i) trajectories of future orientation and hopelessness and (ii) within-indiv...
Article
Both reward sensitivity and impulsivity are related to the development and course of bipolar spectrum disorders (BSDs) and have been implicated in other disorders and negative functional outcomes such as substance abuse, obesity, suicidal behaviors, and risk-taking. Furthermore, according to the transactional component of the Behavioral Approach Sy...
Poster
Inflammation is associated with specific internalizing symptoms, but this relationship has never been investigated using network analysis. Adolescents (N=307) completed a blood draw, Children’s Depression Inventory (CDI) and Multidimensional Anxiety Scale for Children (MASC). We selected adolescents with elevated C-reactive protein (CRP values > 2....
Article
Prior research indicates that cognitive vulnerabilities can render individuals more susceptible to psychopathology in the wake of stressful events. However, little work has directly targeted the neural mechanisms involved. In this study, we examined functional magnetic resonance imaging (fMRI) activity as a function of negative cognitive style, a w...
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It is unclear whether impaired cognition is a risk factor for depression, a consequence of depression, or whether both depression and impaired cognition are caused by a third underlying process (e.g., stress). These three hypotheses were tested in 523 adolescents assessed annually for depression, attentional functioning, and childhood/recent life s...
Article
Past research on emotional clarity (EC), the ability to identify and label one’s own emotions, has illustrated an association between EC deficits and poor psychosocial outcomes during the adolescent years. Although past research has connected EC to psychosocial outcomes during adolescence in cross-sectional and longitudinal designs, no studies have...
Article
Depression is associated with increased emotional response to stress. This is especially the case during the developmental period of adolescence. Cognitive reappraisal is an effective emotion regulation strategy that has been shown to reduce the impact of emotional response on psychopathology. However, less is known about whether cognitive reapprai...
Article
Individuals with bipolar spectrum disorder (BSD) frequently meet criteria for comorbid anxiety disorders, and anxiety may be an important factor in the etiology and course of BSDs. The current study examined the association of lifetime anxiety disorders with prospective manic/hypomanic versus major depressive episodes. Participants were 244 young a...
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Behavioral Approach System (BAS) sensitivity has been implicated in the development of a variety of different psychiatric disorders. Prominent among these in the empirical literature are bipolar spectrum disorders (BSDs). Given that adolescence represents a critical developmental stage of risk for the onset of BSDs, it is important to clarify the l...
Article
Background: The present study sought to better understand the unique profiles of late adolescents' affective functioning by exploring patterns of trait affect and cognitive affective regulation strategies. The study also examined whether these unique profiles significantly predicted depressive symptoms, non-suicidal self-injury (NSSI), and well-be...
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The hopelessness theory of depression is a prominent account of depression that posits that individuals with a negative inferential style are more likely to become hopeless when they experience negative life events (NLEs), and that hopelessness is a proximal cause of depression. There is strong evidence supporting the role of a negative inferential...
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Research suggests that midline posterior versus frontal electroencephalographic (EEG) theta activity (PFTA) may reflect a novel neurophysiological index of approach motivation. Elevated PFTA has been associated with approach-related tendencies both at rest and during laboratory tasks designed to enhance approach motivation. PFTA is sensitive to cha...
Article
In 2 meta-analyses on gender differences in depression in nationally representative samples, we advance previous work by including studies of depression diagnoses and symptoms to (a) estimate the magnitude of the gender difference in depression across a wide array of nations and ages; (b) use a developmental perspective to elucidate patterns of gen...
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Although personality disorders (PDs) are highly comorbid with bipolar spectrum disorders (BSDs), little longitudinal research has been conducted to examine the prospective impact of PD symptoms on the course of BSDs. The aim of this study is to examine whether PD symptom severity predicts shorter time to onset of bipolar mood episodes and conversio...
Article
Positive and negative trait affect and emotion regulatory strategies have received considerable attention in the literature as predictors of psychopathology. However, it remains unclear whether individuals’ trait affect is associated with responses to state positive affect (positive rumination and dampening) or negative affect (ruminative brooding)...
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Major Depressive Disorder is a common mental illness with rates increasing during adolescence. This has led researchers to examine developmental antecedents of depression. This study examined the association between depressive symptoms and the interaction between two empirically supported risk factors for depression: poor recovery of the biological...
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Although research consistently suggests that adolescents in single-mother families are at increased risk for depression, the mechanisms that explain this relationship are unclear. In a community sample of adolescents (N = 368; ages 12-16; 50 % female; 50 % White) and their mothers (42 % single), adolescents completed measures of depressive symptoms...
Article
Most theoretical frameworks regarding the role of life stress in bipolar disorders (BD) do not incorporate the possibility of a changing relationship between psychosocial context and episode initiation across the course of the disorder. The kindling hypothesis theorizes that over the longitudinal course of recurrent affective disorders, the relatio...
Article
A growing body of research suggests that bipolar spectrum disorders (BSDs) are associated with high aggression. However, little research has prospectively examined how aggression may affect time to onset of hypomanic/manic versus major depressive episodes. In a longitudinal study, we tested the hypothesis that aggression would prospectively predict...
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Adolescence marks the emergence of sex differences in internalizing symptoms and disorders, with girls at increased risk for depression and anxiety during the pubertal transition. However, the mechanisms through which puberty confers risk for internalizing psychopathology for girls, but not boys, remain unclear. We examined two pubertal indicators...
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Background: We probe the adolescent gender difference in depression, asking two critical questions. First, most longitudinal studies of gender differences in adolescent depression date from the 1980s and 1990s, raising the need for a body of evidence on whether the developmental pattern is similar or different today. Second, despite the importance...
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Emotion dysregulation has been associated with increases in many forms of psychopathology in adolescents and adults. The development of effective emotion regulation skills is important during adolescence, especially as stressful life events increase during this time. The current study examined two emotion regulation strategies, cognitive reappraisa...
Article
Background: Major depressive disorder often is characterized by a lack of cognitive and emotional flexibility, resulting in an impaired ability to adapt to situational demands. Adolescence is an important period of risk for the first onset of depression, yet relatively little is known about whether aspects of inflexibility, such as rumination and...
Article
Children raised in single-mother families are at increased risk for psychopathology, but the mechanisms that help explain this relationship are understudied. In a community sample of diverse adolescents (N = 385, 52 % female, 48 % Caucasian) and their mothers, we hypothesized that single mothers would be more likely than cohabitating mothers to eng...
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Adolescence is a developmental period associated with heightened risk for both the onset and escalation of suicidal ideation (SI). Given that SI is a potent predictor of suicidal behavior, it is important to develop models of vulnerability for and protection against SI, particularly among young adolescents. This study examined the relative impact o...