Lydia Ferguson's research while affiliated with University of Cambridge and other places
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Publications (12)
The male-specific region of the Y chromosome is evolutionarily predisposed to accumulate genes important for spermatogenesis. Recent work in this laboratory identified two novel Y-linked transcripts that were upregulated in the testis in response to deletions on the chromosome arm Yq. This article reports the further characterisation of these two t...
Potential gene loci detected in Yq contigs. List of potential gene copies found within each genomic contig mapping to mouse chromosome Yq. Gene copies were located via BLAST comparison of reference gene loci to each contig. Start and end points (in bp) for each match are noted, as is the orientation of the potential gene copy, which may in each cas...
Comparison of Sly upstream promoter region with homologous region of Orly. Annotated output from the TFSEARCH scan for potential transcription factor binding sites in the Sly upstream promoter region and the putative Orlyos promoter. Key elements such as the GCCAAT box are highlighted.
Chimeric composition of the Orly locus. Dotter alignment showing the homologies between Orly and its constituent loci. Exon locations of the constituent loci are indicated, as are the novel exons contained in Orly transcripts.
UPGMA Phylogenetic tree of Ssty1, Ssty2 and Orly. Phylogenetic tree of Ssty1, Ssty2 and Orly gene copies using the same alignment used for Figure 12. The UPGMA algorithm was used, rather than the neighbour-joining algorithm used for Figure 12.
ClustalW alignment of Ssty1 and Ssty2. Annotated output from the ClustalW programme, aligning Ssty1 and Ssty2. Exons, coding region and the polyadenylation signal are highlighted for both genes.
UPGMA Phylogenetic tree of Asty and Orly. Phylogenetic tree of Asty and Orly gene copies using the same alignment used for Figure 13. The reference Astx sequence was used as the outgroup to root the tree. The UPGMA algorithm was used, rather than the neighbour-joining algorithm used for Figure 13.
UPGMA Phylogenetic tree of Sly and Orly. Phylogenetic tree of Sly and Orly gene copies using the same alignment used for Figure 14. The reference Xmr sequence was used as the outgroup to root the tree. The UPGMA algorithm was used, rather than the neighbour-joining algorithm used for Figure 14.
Clustal alignments used for tree analysis. ZIP archive file containing the ClustalW alignments used to generate the phylogenetic trees for this project (plain text format).
The male-specific region of the mouse Y chromosome long arm (MSYq) contains three known highly multi-copy X-Y homologous gene families, Ssty1/2, Sly and Asty. Deletions on MSYq lead to teratozoospermia and subfertility or infertility, with a sex ratio skew in the offspring of subfertile MSYqdel males
We report the highly unusual genomic structure o...
Deletions on the mouse Y-chromosome long arm (MSYq) lead to teratozoospermia and in severe cases to infertility. We find that
the downstream transcriptional changes in the testis resulting from the loss of MSYq-encoded transcripts involve upregulation
of multiple X- and Y-linked spermatid-expressed genes, but not related autosomal genes. Therefore,...
Citations
... This is ascribed to a rampant and ongoing genomic conflict between the X and Y chromosomes over the control of offspring sex ratio. Partial deletions of the long arm of the Y chromosome (Yq) lead to sperm head malformation, sperm DNA damage, overexpression of sex-linked genes in spermatids and either a distorted offspring sex ratio in favour of females (for smaller deletions) or sterility (for larger deletions) [3][4][5][6][7]. ...
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... However, some, like H2A.W in plants (Kawashima et al. 2015) and short H2A variants in mammals , show signatures of adaptive evolution. Furthermore, whereas most histones are ubiquitously expressed, many lineage-specific histones, including some plant H2A.W variants and short H2A variants in mammals, are predominantly expressed in germ cells (Govin et al. 2007;Boussouar et al. 2008;Ferguson et al. 2009;Khadka et al. 2020;Lei and Berger 2020;Borg et al. 2021). Such lineage-specific histone variants provide exciting opportunities to reveal novel epigenetic requirements and regulatory mechanisms via innovations in histone functions. ...
... In post-meiosis, H3.3 remains localized on the sex chromosomes of round spermatids (Figure 3b, panels b1, b5, b9) resulting from the meiotic divisions. Round spermatids were small, haploid, round-shaped cells with a centrally located area of round heterochromatin, named chromocenter (Figure 3B, panels b3, b7, b11) (28,50). The sex chromosomes were present in an area of facultative (light grey in DAPI panel) round heterochromatin juxtaposed to the chromocenter (Figure 3b, panels b3, b7, b11) named post-meiotic sex chromatin (PMSC) (51)(52)(53). ...
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... In contrast, Sly and Slxl1 were though to have arisen later, being specific to the Palaearctic clade (Ellis et al., 2011). Sly arose through a fusion of the 5′ region of Slx and the 3′ region of Xlr (Ellis et al., 2007). ...
