Lukasz Smigielski's research while affiliated with University of Zurich and other places

Publications (24)

Article
Full-text available
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface are...
Article
Full-text available
Background Widespread white matter abnormalities are a frequent finding in chronic schizophrenia patients. More inconsistent results have been provided by the sparser literature on at-risk states for psychosis, i.e., emerging subclinical symptoms. However, considering risk as a homogenous construct, as characteristic of earlier studies, may impede...
Article
Full-text available
Background Sertraline is a selective serotonin reuptake inhibitor with specific indications in child and adolescent psychiatry. Notwithstanding its frequent use and clinical benefits, the relationship between pharmacokinetics, pharmacodynamics, efficacy, and tolerability of sertraline across indications, particularly in non-adult patients, is not f...
Article
Full-text available
Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of sc...
Article
Full-text available
As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants...
Article
Full-text available
There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-...
Article
Importance: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological markers of psychosis risk. Objective: To investigate baseline structural neuroimaging differences between individuals at CHR and healthy controls as well as betwee...
Preprint
Full-text available
Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of sc...
Article
Background Between unaffected mental health and diagnosable psychiatric disorders, there is a vast continuum of functioning. The hypothesized link between striatal dopamine signaling and psychosis has guided a prolific body of research. However, it has been understudied in the context of multiple interacting factors, subclinical phenotypes, and pre...
Article
Full-text available
Functional magnetic resonance imaging provides rich spatio-temporal data of human brain activity during task and rest. Many recent efforts have focussed on characterising dynamics of brain activity. One notable instance is co-activation pattern (CAP) analysis, a frame-wise analytical approach that disentangles the different functional brain network...
Preprint
Importance: The ENIGMA clinical high risk for psychosis (CHR) initiative, the largest pooled CHR-neuroimaging sample to date, aims to discover robust neurobiological markers of psychosis risk in a sample with known heterogeneous outcomes. Objective: We investigated baseline structural neuroimaging differences between CHR subjects and healthy contro...
Article
Full-text available
The concept of self and self‐referential processing has a growing explanatory value in psychiatry and neuroscience, referring to the cognitive organization and perceptual differentiation of self‐stimuli in health and disease. Conditions in which selfhood loses its natural coherence offer a unique opportunity for elucidating the mechanisms underlyin...
Article
Full-text available
Background Cortical neuroanatomical abnormalities have been reported along a continuum between individuals with chronic schizophrenia, first-episode psychosis, clinical high risk for psychosis, and healthy individuals self-reporting subclinical psychotic-like experiences (or schizotypy). Recently, the Schizophrenia Working Group within the ENIGMA (...
Article
Full-text available
Functional magnetic resonance imaging provides rich spatio-temporal data of human brain activity during task and rest. Many recent efforts have focussed on characterising dynamics of brain activity. One notable instance is co-activation pattern (CAP) analysis, a frame-wise analytical approach that disentangles the different functional brain network...
Article
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes. The prevailing explanation points to the interplay between predisposing genes and environmental exposure. Accumulated evidence suggests that epigenetic regulation of...
Article
Full-text available
Meditation and psychedelics have played key roles in humankind’s search for self-transcendence and personal change. However, neither their possible synergistic effects, nor related state and trait predictors have been experimentally studied. To elucidate these issues, we administered double-blind the model psychedelic drug psilocybin (315 μg/kg PO)...
Preprint
Full-text available
Functional magnetic resonance imaging provides rich spatio-temporal data of human brain activity during task and rest. Many recent efforts have focussed on characterising dynamics of brain activity. One notable instance is co-activation pattern (CAP) analysis, a frame-wise analytical approach that disentangles the different functional brain network...
Article
Objective There is increasing evidence for altered resting state functional connectivity (rsFC) in adolescents with disruptive behavior. Despite considerable ongoing behavioral research suggesting also important differences relating to reactive and proactive aggression, the corresponding rsFC correlates have not been studied to date. We therefore e...
Preprint
Full-text available
Disruptive behavior in children and adolescents can manifest itself in reactive and proactive aggression and is modulated by callous-unemotional traits and comorbidity. Research on aggression subtype-specific neural correlates is limited and the role of comorbid symptoms largely neglected. The current study clarifies that distinct though overlappin...
Preprint
Full-text available
Objective There is increasing evidence for altered resting state functional connectivity (rsFC) in adolescents with disruptive behavior. Despite considerable ongoing behavioral research suggesting also important differences relating to reactive and proactive aggression, the corresponding rsFC correlates have not been studied to date. We therefore e...
Article
Full-text available
Artworks provide sets of sensory stimuli that allow special insights into cognitive processes complementing results obtained with other experimental paradigms. Examples are given from visual art and music using behavioral measures and neuroimaging technology (fMRI). The following topics are addressed: creation and maintenance of personal identity,...

Citations

... On the other hand, using GWA studies needs at least ten-thousand to hundred-thousand cases and controls to reach genomewide significance, and even though many reach genomewide significance, still several studies are underpowered [98]. However, polygenic risk score (PRS) estimates the effects of many genetic common variants, typically calculated as weighted sum of trait-associated allele instead of the effects of single SNPs, which usually have only very small effect sizes [128]. In the context of PUI research, PRSs could be helpful to combine both genetic aspects and personality traits. ...
... 18 The positive relationship between the schizotypy and schizophrenia patterns has been proved in the first metaanalysis of neuroanatomical mapping of schizotypy. 51 Furthermore, some of the previous studies have found this relation, and argued that schizotypy may lead to schizophrenia and other spectrum disorders. 10,52-55 As per the disconnection hypothesis, the observations of schizophrenia can be generalized to schizotypy. ...
... Notably, these findings converge with those in idiopathic (clinical high-risk) youth, in which accelerated gray matter loss, particularly in frontal regions, was observed in those who developed overt psychosis [68]. These findings, in conjunction with other recent work [69][70][71], suggest that biological factors exert differential influences on behavior at distinct points in development. Failure to progress along normative timetables during childhood (as reflected by flatter trajectories) may put youth with 22qDel at greater risk for developing psychosis, while exaggerated cortical thinning (i.e., steeper age-related slopes) could contribute to psychosis onset in adolescence. ...
... A related paper by Gurholt et al. (2020) examines intracranial and subcortical volumes in adolescents with early-onset psychosis-a severe and often progressive form of the disorder. Recently, ENIGMA working groups have been created to study various conditions on the schizophrenia spectrum-including the first large-scale international studies of schizotypy (Kirschner et al., 2021). These analyses will lend insight into the schizophrenia prodrome and factors that confer resilience to psychosis in unaffected relatives and in the general population. ...
... The relationship of childhood maltreatment, cognitive ability, and psychotic symptoms is complex and multifaceted, and different mechanisms are involved in mediating the pathways [80][81][82]. To explain the underlying association of this relationship, several biological systems have been proposed [83][84][85][86]. First, the dopamine system in striatal regions might be affected through childhood maltreatment [84,86], which has already been associated with psychosis and cognition [87][88][89]. ...
... 87 In particular, if these studies apply pattern recognition or machine-learning methods allowing for individual classifications, 26 the neurobiological refinement of current clinical prediction models could be amplified and ultimately facilitate tailored preventive interventions at the individual level. Future multimodal studies should investigate if enhanced prediction can be obtained using other potential biomarkers beyond FA, such as examined in recent studies on, that is cellular and extracellular WM alterations, 7 fixel-based analyses, 88,89 functional activation 90 and connectivity, 91,92 neural oscillations (EEG), 93 grey matter volume, 94 cortical thickness, 95 and GABA and glutamate levels (MR-spectroscopy). 25 ...
... Lasting functional and structural changes to DMN nodes have been found to correlate with durable psychological changes following a psychedelic experience (Bouso et al. 2015)-including, importantly, increases in mindfulness-related capacities (Sampedro et al. 2017, Smigielski et al. 2019a. Similarly, changes to SN nodes have been linked to acute (Lebedev et al. 2015, Tagliazucchi et al. 2016, Smigielski et al. 2020) and lasting (Lebedev et al. 2016, Sampedro et al. 2017, Mertens et al. 2020) effects of psychedelics-especially effects on the sense of self. ...
... With regard to functional connectivity, proactive aggression (selfreported and with the InterTemporal Aggression Paradigm) was related to a reduced functional connectivity between the left PCC and the right DLPFC, right IPL, right mPFC/ACC, and bilateral precuneus, as well as between the dorsal striatum and insula and supplemental motor area, and high functional connectivity between the left DLPFC and the left inferior parietal lobes in young adults of both genders (Chester et al., 2019;Werhahn et al., 2020;Zhu et al., 2019a). Finally, a negative association was found between functional connectivity between the left inferior ventral striatum and the precuneus and self-reported proactive aggression, but only in men with antisocial personality disorder (ASPD) who were carriers of the low activity MAOA genotype (Kolla et al., 2018). ...
... CAP_Toolbox.git) [21]. The anesthetized mouse dataset consisted of N baseline = 47, N CSS = 25, and N control = 27 scans acquired at 9.4 T with repetition time = 1 s for 360 volumes [16]. ...
... Prediction 3 -Molecular changes give rise to positive formal thought disorder as a function of their efficacy in shallowing Hippocampal cognitive maps It is well established that schizophrenia in general 83 , and thought disorder in particular 84 , has a heritable component. In addition, epigenetic factors are strongly implicated in the aetiology of the disease 85 , providing an entry point into understanding environmental influences on Schizophrenia. Despite this, no single gene has been identified to be fully penetrant in generating Schizophrenia symptoms: Schizophrenia is a complex polygenetic disease. ...