Lucio Cosco's research while affiliated with Azienda Ospedaliera Pugliese Ciaccio and other places

Publications (33)

Article
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Vitamin D might play a role in counteracting COVID-19, albeit strong evidence is still lacking in the literature. The present multicenter real-practice study aimed to evaluate the differences of 25(OH)D3 serum levels in adults tested for SARS-CoV-2 (acute COVID-19 patients, subjects healed from COVID-19, and non-infected ones) recruited over a 6-mo...
Article
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Objective: In the last few years, quality of life (QOL) in people living with HIV (PLWH) gained more attention. Moreover, reaching a good QOL was set up as a main goal for PLWH. Data on QOL of PLWH in Southern Italy are very scarce, as well as data on factors correlated with QOL, we aimed at evaluating QOL in PLWH in our region. We conducted a mult...
Article
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Purpose Tinnitus and equilibrium disorders such as dizziness and vertigo have been reported by patients with COVID-19; however, they have been rarely investigated. The aim of this study was to study the prevalence of subjective tinnitus and dizziness in a sample of COVID-19 patients using an online 10-item close-ended questionnaire. Methods A mult...
Article
The aim of our study was to characterize the repolarization disorders propensity induced by drug-drug interaction. In this observational retrospective study, we report our experience on all elderly patients with ascertained diagnosis of coronavirus disease 2019 through nasopharyngeal swab with real time-polymerase chain reaction at our Pugliese-Cia...
Article
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The multifunctional role of neuron-specific enolase (NSE) in lung diseases is well established. As the lungs are greatly affected in COVID-19, we evaluated serum NSE levels in COVID-19 patients with and without dyspnea. In this study, we evaluated both SARS-CoV-2-infected and uninfected patients aged >18 years who were referred to hospitals in Cata...
Article
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Introduction: We assessed the performance of direct-acting antivirals (DAAs) in hepatitis C virus (HCV)-infected people who use drugs (PWUDs) in terms of sustained virological response (SVR) and adherence rates in comparison to a location-matched cohort of non-PWUD HCV patients. Methods: All consecutive HCV RNA-positive PWUDs were enrolled betwe...
Article
Hydroxychloroquine is an antimalarial drug also known for its anti-inflammatory and antiviral effects, which have raised the interest of many researchers for its potential use in COVID-19 patients. It is known that this drug, being able to influence the cardiac repolarization phase with QTc interval prolongation, can be potentially harmful, chiefly...
Article
Objectives The aim of this study was to evaluate the factors that can influence an incomplete viral response (IVR) after acute and early HIV infection (AEHI). Methods This was a retrospective, observational study including patients with AEHI (Fiebig stages I–V) diagnosed between January 2008 and December 2014 at 20 Italian centres. IVR was defined...
Article
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Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for e...
Article
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COVID-19 is a viral disease secondary to the infection by the SARS-CoV-2 virus that can lead to a severe respiratory distress. The diagnosis of COVID-19 represents a major challenge. Currently the nasopharyngeal or throat swabs for the detection of SARS-CoV-2 RNA by Polymerase Chain Reaction (PCR) is considered the only validated method for the con...
Article
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Background: Viral load peak and immune activation occur shortly after exposure during acute or early HIV infection (AEHI). We aimed to define the benefit of early start of antiretroviral treatment (ART) during AEHI in terms of immunological recovery, virological suppression, and treatment discontinuation. Setting: Patients diagnosed with AEHI (Fie...
Poster
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Our objective was to evaluate the general QOL among PLWH and the factors that could have been associated with. Moreover, a model was set up in order to assess adherence of practice to the current recommended goals (i.e. 90-90-90-90).
Article
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Multiresistant bacteria infections cause widespread morbidity and mortality and lead to an increase in expenses for hospital stays and complications. We describe the case of a 27-year-old patient with puerperal sepsis after cesarean section due to Escherichia coli complicated by multiresistant Klebsiella ESBL-producing superinfection with septic sh...
Article
Background: We ran a compassionate use nationwide programme (ABACUS) to provide access to ombitasvir, paritaprevir, and ritonavir, with dasabuvir, plus ribavirin for hepatitis C virus (HCV) genotype 1 infection and ombitasvir, paritaprevir, and ritonavir, plus ribavirin for HCV genotype 4 infection in patients with cirrhosis at high risk of decomp...
Article
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Introduction: It is currently believed that Southern Italy (Calabria in particular) is less affected by the HIV epidemics than the rest of Italy. Detailed regional analyses are very important to define characteristics of HIV epidemics, across Italy and among different Italian regions. The impact of migration and socio-economical conditions may cont...
Article
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Background and Objectives: HIV epidemics may differ among epidemiological contexts. We aimed at constructing an HIV clinical cohort whose main epidemiological, clinical and therapeutical characteristics are described (the CalabrHIV cohort, Calabria Region, Southern Italy). Methods: The CalabrHIV Cohort includes all HIV patients on active follow-up...
Article
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We present clinical cases, which underline some difficulties in diagnosis and treatment of hepatitis C virus (HCV) infection. Case report #1 shows a patient who avoided clinical follow-up for HCV until the development of hepatocellular carcinoma. In this patient, non-invasive procedures did not allow to make a differential diagnosis between hydatid...
Article
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The epidemiological profile of HCV infection is evolving in Europe, as well as in Italy. We have previously showed genotype distributions and their dynamics in 2,153 HCV RNA positive patients living in Calabria, Southern Italy, over 11 years. In this study, we extend and update this information by evaluating a hospital-based cohort of 945 HCV RNA p...
Article
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The SINERGIE (South Italian Network for Rational Guidelines and International Epidemiology) project is intended to set up a collaborative network comprising virologists, clinicians and public health officials dealing with patients affected by HCV disease in the Calabria Region. A prospective observational data-base of HCV infection will be develope...
Article
Treatment choice for chronic HBV infection is a continuously evolving issue, with a wide range of options. We aimed to evaluate the current practice of HBV therapies in the real world in Southern Italy. A prospective study enrolling over a six month period (February-July 2010) all consecutive HBsAg positive subjects, never previously treated, refer...
Article
Hepatitis C virus (HCV) variability is mainly attributed to the ability of the virus to respond to host immune pressure, acting as a driving force for the evolution of quasispecies. This study was aimed at studying the changes in HVR-1 heterogeneity and the evolution of HCV quasispecies in HIV/HCV-coinfected patients according to the pattern of res...
Article
Hepatitis C virus (HCV) variability is mainly attributed to the ability of the virus to respond to host immune pressure, acting as a driving force for the evolution of quasispecies. This study was aimed at studying the changes in HVR-1 heterogeneity and the evolution of HCV quasispecies in HIV/HCV-coinfected patients according to the pattern of res...
Article
Full-text available
Background. We obtained estimates of the incidence of tuberculosis (TB) among patients receiving HAART and identified determinants of the incidence. Methods. We analyzed the incidence of TB during the first 3 years after initiation of HAART among 17,142 treatment-naive, AIDS- free persons starting HAART who were enrolled in 12 cohorts from Europe a...
Article
Full-text available
CMV infection is a major cause of disease following renal transplantation. Clinical diagnosis is difficult because the virus usually produces only few, if any, symptoms. Consequently rapid and sensitive diagnostic methods are needed, since clinically effective antiviral therapy is available. Qualitative-quantitative detection of CMV-DNA in leukocyt...
Article
The early detection of mutations in the HIV-1 polymerase is a key point in the management of anti-retroviral therapy. While nucleotide substitutions and insertions have been well and frequently desribed in literature as linked to drug resistance, deletions have been rarely observed and desribed (ART67, Imamichi et al.). The aim of this study is to...
Article
Background: Fulminant hepatitis on withdrawal of chemotherapy has been described in chronic hepatitis B virus infection, but not in hepatitis C virus (HCV) infection. The relation between HCV and immune response to this virus, and disease severity, has not been examined. We present two patients with HCV who developed fulminant liver failure after...

Citations

... A multicenter study measured [25(OH)D 3 ] in patients that had acute COVID-19, patients that had healed from COVID-19 and noninfected patients; the study showed that acute COVID-19 patients had the lowest levels of [25(OH)D 3 ] (9,63 ± 8.70 ng/mL), followed by healed patients (11.52 ± 4.90 ng/mL, p>0.05), with the highest levels reported by non-infected patients (15.96 ± 5.99 ng/mL, p = 0.0091) (104). The most recent systematic review and meta-analysis which involves approximately two million adults suggests that vitamin D insufficiency/deficiency increases susceptibility to COVID-19 and to severe COVID-19, with association regarding mortality reported as less robust (105). ...
... Although not specific to pulmonary disease, several biomarkers of different stages of lung involvement in COVID-19 have been identified and have been associated with pulmonary and systemic hyperinflammation and fibrotic damage (12). In the early disease course, neuron-specific enolase (NSE) can be used to differentiate patients who are going to develop dyspnea (21). On admission, higher lymphocyte and platelet counts and lower ferritin, Ddimer, lactate dehydrogenase (LDH), and aspartate transaminase (AST) have all been associated with lower risk of mortality in COVID-19 patients who ultimately required intubation and mechanical ventilation (22). ...
... The high rate of SVR reported in both clinical trials and reallife observations around the world [6,7,[19][20][21][22][23][24] was also confirmed in our study. Moreover, our results corroborate those reported in a similar experience that prospectively recruited about 1500 PWIDs inside SerDs distributed all over Italy [25]. The authors showed a significantly higher SVR rate and treatment adherence among PWID followed in the SerDs group than those followed directly by liver centers. ...
... Nevertheless, otitis has already been highlighted as an unusual presentation that rarely occurs in conjunction with common viral symptoms or as an isolated disorder [1]. The damaging impact of the COVID-19 virus on the inner ear has been explored [2][3][4]. It was found that cochlea involvement could be frequent even without major general symptoms [3] or sporadic, like radiology-proven acute labyrinthitis [5]. ...
... Our findings are in line with those of several clinical trials which failed to demonstrate significant advantages in terms of both virological suppression and size of viral reservoirs in patients starting intensified four-or five-drug antiretroviral regimens compared to those treated with standard PI-or NNRTI-based triple ART [16][17][18]22,25]. On the contrary, a recent study found that starting ART with regimens not recommended by the current guidelines, including those intensified with more than three drugs, increased the risk of an incomplete viral response in patients diagnosed with acute or early HIV infection [26]. ...
... This may have been caused by a lack of seroconversion in some patients, as plasma was collected within the first week after hospital admission. According to the literature, at least 11-14 days after the onset of the disease is reported to be necessary to observe an average seroconversion rate of approximately 90%-100% for antibodies (IgM or IgG) against the SARS-CoV-2 S and N proteins (31,(60)(61)(62)(63)(64)(65)(66)(67)(68)(69). Future investigations of the antibody dynamics, including in the early (acute) and late (convalescent) phases of COVID-19 infection, may provide more insight into this issue. ...
... However, these results clearly indicate that RDT is not recommended as a diagnostic tool for COVID-19. 11 Asymp Value. Sig (2-Sided) in Table 2 shows the p value or the significance of the OR value. ...
... This rapid normalization of the CD4/CD8 ratio, already observed in the setting of PHI [33], is in contrast with data from chronic HIV infection indicating that a similar rate of normalization was achieved after a median of 10 years with suppressive ART [34]. Although we did not confirm a significant association between the timing of ART initiation and immune recovery, as already reported [9,33], the finding that a more preserved immunological condition at the time of therapy start strongly predicted the achievement of a CD4/CD8 ratio ≥1 might suggest a key role of an early ART in immune restoration Finally, our study confirmed the optimal results of a rapid ART approach in PHI patients in terms of linkage to care (more than 90%) and acceptability, as already demonstrated in previous reports [12,20]. ...
... Of the 83 studies included in the SLR, 61 were published as peer-reviewed publications , and 22 were conference proceedings (availability as abstracts or posters) . Including studies that recruited patients from multiple countries, the most common study locations were the US (N = 50), [21, 22, 24, 27-29, 33, 34, 39-41, 43-45, 50, 51, 54, 56, 57, 59, 61, 62, 68-71, 73-77, 79-85, 87-92, 94, 95, 97-100] Spain (N = 15) [26, 28, 30-32, 35-37, 42, 47, 49, 58, 66, 79, 96], and Italy (N = 13) [18,20,23,25,48,52,53,55,64,67,72,79,86]. A variety of study designs were captured: 27 were non-comparative retrospective studies [18,19,22,24,25,28,32,33,40,41,79,81,[84][85][86][87][88][89][90][91][92][94][95][96][97][98][99], 14 were case series [20, 21, 29, 31, 34-39, 42, 43, 82, 100], five were comparative (including two cohort studies [80,83], and three case-control studies [23,26,27]) and one was a non-comparative prospective study [30]. ...
... Petta et al. [22], in their prospective study that used OBV/PTV/r, with or without DSV, plus RBV for treatment of patients with HCV GT1 or GT4 infection with cirrhosis, found that there were increases in the serum bilirubin levels, which was probably owing to inhibition of the bilirubin transporters OATP1B1 and 1B3 by paritaprevir and RBV-induced hemolysis, rather than hepatotoxicity caused by OBV/PTV/r treatment, in addition to significant improvement of liver functions 12 weeks after treatment, with no significant change in INR, and these findings were in agreement with our results. ...