Lucas Vicuña's research while affiliated with Universität Heidelberg and other places

Publications (3)

Article
Full-text available
Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, persists in peripheral sensory ne...
Article
Full-text available
Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds of genes across sham and nerve...

Citations

... In the immune system, several semaphorins act as immune checkpoints (reviewed in ref. [11,12]). All vertebrate semaphorins functionally use plexins as receptors in non-lymphoid [13,14] and lymphoid [15][16][17] tissues. We previously have shown that two Class IV neuroimmune semaphorin molecules, Sema4A and Sema4D, display the opposite effects in vivo in allergic airway inflammation. ...
... HNE is also secreted by a variety of other immune cells, namely, MDSCs, macrophages, and lymphocytes. 31,32 As a matter of fact, HNE is upregulated in numerous cancer types. The HNE levels appear significantly elevated in the setting of cancer, even when compared to non-malignant inflammatory diseases with the exception of cystic fibrosis. ...