Luca Morelli’s scientific contributions

Our study was born from the observation of a clinical case of a boy who arrived in the Emergency Room of our hospital for persistent hyperpyrexia, headache and prolonged emetic episodes and complaining of objective photophobia and dizziness. The patient underwent haematochemical tests, chemical-physical examination of Chronic Fatigue Syndrome (CFS), negative for bacteria, negative for Neisseria Meningitidis, Escherichia Coli 121, Haemophilus Influenzae, Stafilococcus Pneumoniae, Stafilococcus Agalactiae and with slightly positive reaction to Pandy’s test; he was subjected to neurological examination, to Nuclear Magnetic Resonance of the brain and encephalic trunk with contrast agent which resulted negative, and to EEG that showed a slightly slowed-down brain electrical activity, in right occipital region, and frontal irritative abnormalities. Given these clinical and instrumental investigations, an acute meningoencephalitis was diagnosed. During his hospitalization, the patient was treated with intravenous antibiotic therapy and intravenous antiviral therapy for 12 days. At discharge, in the absence of specific therapy, and considering the protraction of the cephalic, dizzying, asthenic and myalgic symptoms and in relation to hematochemical and serological tests (positive for antibodies to Herpes 1 IgG), Epstein Barr Virus antibodies (positive for Viral Capsid Antigen IgG and IgGE BNA, for Extractable Nuclear Antigen and IgG Cytomegalovirus) he was diagnosed a Post-infectious CFS. The patient was treated with Oxygen Ozone Rectal Insufflative Therapy on a bi-weekly basis for 4 weeks, associated with Micetrin, a dietary supplement with sweetener based on Vitamin C, Shitake, Reishi, Maitake, Cordyceps, Magnesium and SOD, continued the treatment on a weekly basis for a further 4 weeks until the complete remission of the symptoms of asthenic, neurological and clinical parameters.

Oxygen-ozone therapy is effective for both activation of the cerebral microcirculation and increasing energy production by neurons, as recent studies have shown. As well as this, it has been shown to have a proven anti-inflammatory and antispasmodic action, improve microcirculation, increase the production of cellular energy, activate the mitochondrial antioxidant system and facilitate the elimination of cell catabolites. It also seems that oxygen-ozone therapy improves and prolong the effects of drugs such as Levodopa, Selegiline and Bromocriptine and antioxidants, therefore these activities could help us understand the improvements recorded in Parkinson’s patients treated with oxygen-ozone therapy. The aim of our work was to carry out a postural, stabilometric and symptomatological assessment of the effects of oxygen-ozone therapy by using rectal insufflation in patients who undertook the intense motor activity of non-contact boxing. The results showed a significant reduction in the myofunctional, postural and stabilometric symptoms of Parkinsonian patients who practiced non-contact boxing activities, implemented though systemic oxygen-ozone therapy with insufflation.

Idiopathic low back pain can be considered as a chronic condition, characterized by recurrent episodes of pain and functional limitation. The aim of this study is to compare two therapeutic methods to treat this chronic disease: the oxygen-ozone therapy and the diathermy through Tear® therapy. Two groups of 10 patients each who suffered from postural idiopathic low back pain due to different pathologies have been recruited. All selected patients have been evaluated through spinometry and have been given the Oswestry low back pain disability questionnaire to fill in at the beginning of the treatments and at the end of them with a three-month follow-up. The first group underwent a diathermy treatment through Tecar® therapy, whilst the second group received an oxygen-ozone therapy treatment through a paravertebral lumbar infiltration; both treatments have been associated with a standard physiokinesitherapy treatment. Data collected through Formetric spinometry show an improvement in both groups, but in the second group (treated with oxygen-ozone therapy+physiokinesitherapy), the improvement is greater (from 6% to 57%) against the first group (from 20% to 38%). In conclusion, the study has cor roborated the validity of both treatments leading to improvement of symptomatology, but while one treatment leads to some relapses after a few months, the second one has a greater healing effect, which preserves over time.