Loubna Mezouar's research while affiliated with Centre Hospitalier Universitaire Mohammed VI and other places
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Publications (28)
Plasmacytoma of the skull base is a rare entity. We present a case of sphenoid plasmacytoma in a 51-year-old woman who had nasal obstruction, intermittent epistaxis, headaches, decreasing visual acuity, and diplopia. Computed Tomography (CT) scan and magnetic resonance imaging (MRI) showed a large heterogeneous, expansile lesion measuring 75 mm × 5...
Mediastinal Seminoma is one of the malignant germ cell tumors of the mediastinum. It is a rare tumor that represents only 1%-4% of mediastinal tumors. We report the case of a patient treated at the Oncology Center of Oujda for a pure primitive seminoma of the mediastinum, with a review of the literature to assess the epidemiological, clinical, ther...
Malignant primary rectal melanomas (PRM) are rare tumors. Their diagnosis is frequently delayed as these lesions are often mistaken for benign diseases, resulting in extremely poor overall survival. Histological evaluation with special immunohistochemical (IHC) stains is often indispensable for a definitive diagnosis. The main treatment for this co...
Hidradenocarcinomas or malignant hidradenomas are tumors developed from the sweat glands, in particular, the eccrine glands. It is a rare entity of skin tumors and frequently appears de novo with a slight female predominance and an average age of 50 years at diagnosis. We report the case of a 57-year-old woman treated for localized hidradenocarcino...
Primary vaginal sarcoma is a rare disease entity, reported in less than 3% of cases of vaginal cancers. We report the observation of a patient treated at the regional oncology center of Oujda in Morocco who is presented with a non-metastatic primary vaginal leiomyosarcoma of 20 cm. The treatment consisted of neoadjuvant chemotherapy, followed by he...
Botryoid sarcoma is a subtype of rhabdomyosarcoma affecting soft tissues and exceptionally the cervix. We here report the case of an 18-year-old female patient presenting to the emergency department with a feeling of pelvic heaviness, metrorrhagia and urinary retention. Gynecological examination showed budding mass of the uterine cervix. The biopsy...
Osteosarcomas of the craniofacial bones account for less than 10% of all osteosarcomas. Primary osteosarcomas of the nasal cavity and paranasal sinus are rare localization (0.5%-8.1% of osteosarcomas occur in this site). Accordingly, we report a case of osteosarcoma arising de novo from the ethmoid bone in a 46-year-old female. Initially, she prese...
Hemangiopericytomas or solitary meningeal fibrous tumors are extremely rare mesenchymal tumors. They represent only 1.6% of all central nervous system tumors, occurring mainly in adults between 40 and 50 years of age with a slight male predominance. We report the observation of a 20-year-old man treated at the Oujda Regional Oncology Center for cer...
Transitional cell carcinoma (TCC) is an extremely rare gynecologic tumor, particularly in the endometrium. All endometrial TCC cases reported so far in the literature were diagnosed at relatively advanced stages. In the present article, we report a pure primary endometrial TCC initially revealed by an abdominal mass and classified as an Internation...
Radical prostatectomy in high-risk prostate cancer patients has long been followed by immediate adjuvant radiotherapy (IART) to increase biochemical relapse-free survival. However, the increased urinary and digestive radio-induced toxicities have raised questions about the safety of delaying radiotherapy until the occurrence of biochemical or clini...
Chondrosarcomas are malignant cartilage-forming tumors representing less than 0.1% of all head and neck malignancies, and nasal cavity is an exceptional location among them. Clinical presentation could be consisting of either rhinological signs or asymptomatic endonasal mass. None of the previous reports mentioned ophthalmological symptoms at the f...
Neurofibromatosis type 1 (NF1) is a genetic disorder associated with high rates of neural crest-derived tumors, both benign and malignant. Many series have identified cutaneous melanoma as a rare tumor among cancers occurring in individuals with NF1 disease, but the mucosal location has to date never been reported. In this paper, we report an oral...
Dermatofibrosarcoma is a rare cancer, accounting for 0.01% of all cancers. We here report the case of a 44-year-old female patient presenting with the 5th recurrence of locally advanced Darier-Ferrand dermatofibrosarcoma, that progressed on many cycles of neoadjuvant therapy and required emergency radiotherapy with good response. This allowed to pe...
Le chordome sacrococcygien est une entité pathologique rare, rapporté dans seulement moins de 3% des cas. Nous allons rapporter l´observation d´une patiente prise en charge au Centre Régional d'Oncologie d'Oujda au Maroc ayant présenté un chordome sacrococcygien localement avancé. Le traitement a consisté en une radiothérapie exclusive sur la tumeu...
Background: The aim of the study was dosimetric effect quantification of exclusive
computed tomography (CT) use with an intravenous (IV) contrast agent (CA), on dose
distribution of 3D-CRT treatment plans for lung cancer. Furthermore, dosimetric advantage
investigation of manually contrast-enhanced region overriding, especially the heart.
Materials...
Although primary breast cancer (BC) is the most frequent cancer in the world, their mammary metastases are rare. In this paper, we report the case of a 51-year-old male patient diagnosed with a mammary lump and an intracranial hypertension syndrome. Mammography showed the presence of an irregular opacity without microcalcifications. After a cytolog...
Introduction:
Lung cancer is the most common cancer in men living Eastern Morocco. We here present the first report on the clinical, pathological and therapeutic features of lung cancer in Eastern Morocco.
Methods:
We conducted a retrospective study of 738 patients diagnosed with lung cancer at the Hassan II, Oncology Center between October 2005...
Peripheral neuroectodermal tumors (PNET) of the kidney are extremely rare. They are often diagnosed at a late stage due to their nonspecific clinical presentation. Treatment of patients with metastases is based on palliative chemotherapy. We here report a case of PNET of the kidney with sudden onset of metastases to the lymph nodes and to the skin....
Résumé
Objectifs
Nous avons évalué la toxicité thyroïdienne liée à la radiothérapie adjuvante hypofractionnée d’un cancer du sein localisé.
Matériel et méthode
Il s’agit d’une étude prospective, qui a inclus 50 patientes, irradiées en situation adjuvante pour un cancer du sein, dont seulement la moitié a bénéficié d’une radiothérapie sur la régio...
Vulvar cancer is a rare neoplastic disorder accounting for less than 5% of female genital cancers. This study aims to describe the epidemiological, clinical, paraclinical, therapeutic and evolutionary profile of vulvar cancer in the population of the eastern region of Morocco. We conducted a retrospective study of all patients treated for vulvar ca...
Introduction
This is a prospective study aiming to describe how cervical cancer and its treatment can affect the sexuality of a specific population of Moroccan women survivors of this disease.
Materiels and Methods
It is a comparison of clinical features and Female Sexual Function Index (FSFI) of 3 balanced groups of women, made up of 100 survivor...
Objective: The aim of our study was to identify potential predictive factors beyond pathologic response after neoadjuvant radiochemotherapy.Patients and Methods: Between January 2009 and December 2014, 40 patients with rectal carcinoma were included in the study. The treatment consisted of radiation ranging between 39 and 50.4 Gy associated with a...
Introduction:
The present study aimed to detect the factors associated with psychological distress (PD) in young Moroccan patients with breast cancer, with a special focus on the type of surgical procedure.
Patients and methods:
We collected social, demographic, and clinical data from female patients, aged < 45 years, with localized stage breast...
Le choriocarcinome est une tumeur trophoblastique hautement maligne. La plupart des cas de choriocarcinome sont intra utérins et d'origine gestationnelle. Le choriocarcinome chez les femmes ménopausées est extrêmement rare. Nous rapportons une observation originale d'une femme ménopausée et nullipare présentant un choriocarciome endometrial non ges...
L'hidradénocarcinome est une tumeur annexielle maligne extrêmement rare. Caractérisée par la fréquence des récidives locorégionales et des métastases à distance. Le diagnostic histopathologique de malignité se fait sur des critères architecturaux et cytologiques particuliers .la chirurgie d'exérèse large représente l'essentiel du traitement. Une ra...
Background: The risk of tamoxifen related endometrial neoplasm has been confirmed by multiple studies. Case: The case of a 65-year-old multiparous postmenopausal woman who received tamoxifen 20mg daily for 4 years after the treatment of breast cancer is presented. Four years after initiation of tamoxifen treatment, the patient developed a malignant...
Le cancer du sein sur tissu mammaire ectopique est une tumeur rare qui représente 0,2 à 0,6% de l'ensemble des cancers du sein. Les auteurs en rapportent 2 cas pris en charge dans 2 centres d'oncologie marocains. Il s'agit de 2 patientes âgées de 31 ans et 47 ans présentant un cancer du sein sur tissu mammaire ectopique en situation axillaire. Une...
Citations
... Prostate cancer is a common malignant tumor of male genitourinary system, and its incidence has increased sharply year by year in the world (Abu-Ghanem et al., 2015). Radical prostatectomy (RP) has become one of the most effective methods for the treatment of prostate cancer (Berhili et al., 2022). Urinary incontinence has become the most important complication after RP due to the possible injury of muscles and nerves related to urinary control around the prostate during the operation. ...
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... It is a rare malignant tumor with an annual incidence estimated between 0.5 and 8 cases per 1,000,000 inhabitants [1] . The sacrococcygeal region is the most common site of chordoma [2,3] . The mitotic activity of tumor cells is very low [4] . ...
... Bronchopulmonary cancers are a malignant tumor entity, the most common of which are primary and are the leading causes of death worldwide [1]. These cancers are more common in humans and tobacco seems to be the first risk factor accused in their development [2]. ...
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... However, the start of treatment may be delayed in some clinical scenarios, especially in developing countries such as Iran due to their limited access to radiotherapy facilities (Mayadev et al., 2022). In such situations, it is suggested to use chemotherapy as an auxiliary approach with the aim of reducing the load of the accelerator device and create an opportunity to plan the treatment while inducing a significant oncologic effects (Ahmed et al., 2021;Ouabdelmoumen et al., 2018). Such an approach may be associated with a significant reduction in tumor size, a reduction in the risk of distant metastasis, and an increase in the probability of clinical response. ...
... Mais il n'y avait pas d'augmentation du risque mis en évidence chez les femmes ayant eu une irradiation sus-claviculaire par rapport à celle ne l'ayant pas eu [14]. Par la suite, plusieurs études sont venues contredire ce premier résultat avec une augmentation du risque d'hypothyroïdie chez les patientes ayant eu une irradiation sus-claviculaire [15][16][17]. Le développement de la RCMI dans l'irradiation adjuvante du sein a conduit aux mêmes problématiques qu'en radiothérapie des cancers des VADS : bien que les doses finales délivrées soient plus faibles, le volume thyroïdien irradié est plus élevé qu'en technique tridimensionnelle. Ainsi, l'un des facteur de risque pourrait être un faible volume thyroïdien avant irradiation (< 8 cm 3 ) conduisant à un volume final de thyroïde irradié plus important [18]. ...
... 3.6.1. The treatment strategy for cervical cancer in Morocco Treatment strategies for precancerous lesions or cervical cancer were reported in only eight studies (n = 8) [5][6][7]10,11,16,43,55]. The most responsive treatment strategy was concomitant radiochemotherapy (43.7−78.9 ...
... [10][11][12][13][14] According to some studies, the expression of PD-L1 in intra-tumoral lymphocytes may also play a role in immune suppression, even when it is not expressed by tumor cells. [15][16][17][18][19] However, the expression of PD-L1 by tumor cells and/or the microenvironment varies according to tumor type and the prognostic implications remain controversial. [20][21][22][23][24][25] In addition, the expression of PD-L1 by tumors suggests a possible prognostic impact and the possibility of immunotherapy via PD-1 blockade. ...
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... Eleven studies evaluated the psychological effects of breast cancer surgery on AYA patients. Multiple studies showed that a mastectomy was associated with worse quality of life factors, such as body image, sexual health, and anxiety, compared to patients who underwent BCS [59][60][61]. Many patients chose mastectomy out of fear of potentially leaving cancer cells behind and the desire to avoid future screening imaging [62]. ...
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... The diagnosis of certainty is based on the anatomopathological study which shows an intradermal tumoral proliferation in sheet, comprising a sudoral differentiation and cut by a dense and hyalinized stroma with nuclear pleomorphism and figures of mitoses [6]. ...
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