Lorenzo Lorenzo-Luaces’s research while affiliated with Indiana University Bloomington and other places

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Publications (151)


Social media use and transdiagnostic dimensions of psychopathology: Relative effects of frequency and problematic social media use
  • Preprint

May 2025

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10 Reads

Lorenzo Lorenzo-Luaces

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Meghana Boinpally

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Johan Bollen

Background: Social media has been identified as a possible risk factor for depression in young adults, though it is unclear if it is associated with other dimensions of psychopathology. Moreover, it is unclear what aspects of social media use beyond frequency are associated to symptoms. Methods: A large sample of young adults (N= 7453) participated in a screening of transdiagnostic symptoms of psychopathology (i.e., depression, panic, generalized anxiety, social anxiety, alcohol use, drug use, insomnia, and pain). We correlated depression scores to time spent on social media and problematic social media use. We used a principal components analysis to identify shared dimensions of psychopathology and explored the correlations between symptom dimensions and social media use. Results: Participants who reported higher social media usage exhibited significantly higher self-reported depression. Our PCA suggested two dimensions of psychopathology consistent with the HiTOP model which we dubbed “emotional” and “externalizing” symptoms. Time spent on social media was correlated with emotional symptoms and with externalizing symptoms, albeit to a lesser extent. However, these associations were not significant after controlling for problematic social media use, which had differential relations to dimensions of psychopathology. e-value analysis suggested that unmeasured confounds could potentially explain these associations. Discussion: The association between time spent on social media and psychopathology could be accounted for by the way in which social media is used. However, unmeasured confounding remains a threat to these inferences.


Heterogeneity in Item Content of Quality of Life Assessments Used in Depression Psychotherapy Research

March 2025

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4 Reads

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1 Citation

Quality of life (QOL) broadly encompasses constructs including health, well-being, life satisfaction, and psychosocial functioning. Depression, a major cause of global disability, is linked to lower QOL. Despite the rise of measurement-based care and patient-reported outcomes, there is no consensus on QOL definitions or models, resulting in varied assessments. This study aims to describe the item content overlap among commonly used QOL measures in depression research. We analyzed 10 QOL measures from a meta-analysis, calculating Jaccard indices to quantify overlap, and used two coding approaches: one for similarly worded items and another for exact word matches. We also categorized items into broader themes. At the most, average Jaccard similarity was M = 0.14 (SD = 0.12), indicating significant heterogeneity among QOL measures in depression. This suggests that QOL outcomes may not be reproducible across different scales. Future research should examine the relationships between the content assessed by various QOL measures.



One shot intervention reduces online engagement with distorted content

March 2025

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5 Reads

PNAS Nexus

Depression is one of the leading causes of disability worldwide. Individuals with depression often experience unrealistic and overly negative thoughts, i.e. cognitive distortions, that cause maladaptive behaviors and feelings. Now that a majority of the US population uses social media platforms, concerns have been raised that they may serve as a vector for the spread of distorted ideas and thinking amid a global mental health epidemic. Here, we study how individuals (N=838) interact with distorted content on social media platforms using a simulated environment similar to Twitter (now X). We find that individuals with higher depression symptoms tend to prefer distorted content more than those with fewer symptoms. However, a simple one-shot intervention can teach individuals to recognize and drastically reduce interactions with distorted content across the entire depression scale. This suggests that distorted thinking on social media may disproportionally affect individuals with depression, but simple awareness training can mitigate this effect. Our findings have important implications for understanding the role of social media in propagating distorted thinking and potential paths to reduce the societal cost of mental health disorders.


Bootstrapped aggregate CDS prevalence distributions for each GAD-10 severity class. Note Each bar above with the sample size of the corresponding severity class. The colored box represents interquartile range, while the horizontal lines correspond to 95% CI. Our results show a trend of increasing CDS prevalence as severity increases, with pairwise significant differences denoted by braces
Bootstrapped aggregate CDS prevalence distributions for each PHQ-9 severity class. Note. Each bar is annotated above with the median and 95% CI bounds in brackets. The colored box represents interquartile range, while the horizontal lines correspond to 95% CI. Pairwise significant differences denoted by braces
Pairwise Spearman rank-order correlation coefficients between (a) GAD10, PHQ9 and confounding variables and (b) accounting for shared and unique variance between PHQ9 and GAD10. Note. Significance of results denoted below the coefficient value by **: p < 0.01 and *: p < 0.05
Anxiety and Depression are Associated with More Distorted Thinking on Social Media: A Longitudinal Multi-Method Study
  • Article
  • Full-text available

March 2025

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34 Reads

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1 Citation

Cognitive Therapy and Research

Background Depression and anxiety are associated with patterns of negative thinking that can be targeted through cognitive restructuring as a part of cognitive therapy (CT) or cognitive behavioral therapy (CBT). Our team has created a set of cognitive distortion schemata (CDS) n-grams based on theories underlying CT to measure the linguistic markers that indicate cognitive vulnerability to depression. These CDS were specifically designed to examine online language. Our prior work supports a relationship between CDS and a diagnosis of depression, but less is known about the relationship between online language, CDS, and anxiety. The current study measures if CDS can be detected in people who report anxiety symptoms, and whether CDS increase with symptom severity. Methods 1,377 participants were recruited from a study assessing social media use and mental health symptoms, the Studies of Online Cohorts of Internalizing Symptoms and Language (SOCIAL). From this, 804 timelines were harvested, and after removing missing data and bots, our final sample was 537 respondents who posted 999,859 tweets. This is a longitudinal, multi-method design, using surveys and text-based analysis of social media timelines. We used bootstrap resampling to compare differences in CDS prevalence in anxious and depressed participants. Results CDS can be observed in anxiety disorders, significantly increase as a function of anxiety symptom severity, and are related to depression and anxiety comorbidity. Conclusions Using behavioral, affective, and cognitive indicators of distorted thinking from social media may yield new insight into the trajectories of depression and anxiety. This work has implications for the future of CT/CBT and other online interventions that target distorted thinking styles.

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Treatment adherence, therapeutic alliance, and clinical outcomes during an exposure-based cognitive-behavioral therapy for pediatric irritability

February 2025

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57 Reads

BMC Psychiatry

Background This study explores changes in treatment adherence and alliance during a novel parent- and child-psychotherapy for pediatric irritability. Associations between in-session therapeutic processes and symptom change were examined. Methods Forty participants (Mean age = 11.23, SD = 1.85; 37.5% female, 77.5% white) with severe irritability, and their parents, received 12 sessions of exposure-based cognitive behavioral therapy (CBT) with parent management training (PMT). Measures included clinician-rated adherence to the manual, alliance scales (Alliance Scale for Children-revised; TASC-r, and Working Alliance Inventory; WAI, respectively), and clinician-, parent- and child-reported irritability scales (Affective Reactivity Index; ARI). Linear mixed models examined session-by-session changes and associations between adherence/alliance and subsequent irritability, and vice versa. Results First, adherence to standard treatment elements decreased over time (Bs ≥ − 0.03, ps ≤ 0.010), while the focus on specific treatment components increased (i.e., exposure: B = 0.15, p = 0.001; PMT: B = 0.07, p = 0.002). Second, adherence to standard treatment elements were associated with decreased clinician-reported irritability (Bs ≥ − 2.23, p ≤ 0.042). For the alliance measures, parent-reported alliance increased over time (Bs ≥ 0.10, p ≤ 0.01); child-reported alliance did not change. Bidirectional associations were found between alliance and symptoms; specifically, child-reported alliance predicted clinician-rated irritability at next session (Bs ≥ − 0.66, p ≤ 0.053), and decreases in clinician- (Bs ≥ − 0.02, ps ≤ 0.043) and parent- (B = − 0.15, p = 0.024) reported irritability predicted increased alliance at next session. Conclusions Findings underscore the predictive role of treatment adherence and therapeutic alliance on outcomes, in exposure-based CBT for pediatric irritability. Trial registration ClinicalTrials.gov identifier: NCT02531893; date of registration: 25/08/2015.


“Informed” Consent? Ethical Considerations for Clinicians Using Therapy-Matching Platforms

December 2024

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14 Reads

Mental health care in the United States is prohibitively difficult to access. Barriers of entry include a shortage of providers, high cost of services, insufficient insurance coverage, and layers of bureaucracy. This problem of low supply and high demand created a unique environment for capitalist problem solvers to enter the therapeutic market, via "therapy-matching platforms." Several ethically related Federal Trade Commission (FTC) complaints and independent investigations into these platforms highlight that the forward progress is not without growing pains. This commentary focuses on ensuring proper informed consent when providing services on therapy-matching platforms (e.g., BetterHelp, TalkSpace). (PsycInfo Database Record (c) 2024 APA, all rights reserved).


A first look at diversity gaps in psychotherapy research publications and representation

November 2024

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158 Reads

Abstract Objective There is a pervasive underrepresentation of researchers and clinicians from diverse backgrounds in psychology. This is the first study to focus on diversity gaps in Psychotherapy Research. We examine a gap in the representation of research from low-income countries and summarize barriers and solutions to increase diversity in the field. Method We examined trends in submission, acceptance, and rejection rates of all submissions (n = 7183) from 75 countries, representing eight geographical regions to Psychotherapy Research, between 28 April 2005 and 22 June 2023. Results Most submissions were from Europe and North America, with the fewest from Africa and Asia/Northeast Asia. High-income countries had significantly more submissions than low-income countries, with gaps increasing over time. North America and Europe had the highest acceptance rates and Africa and Asia/Southeast Asia had the lowest rates. Conclusion Psychotherapy Research is one of the most internationally representative journals in the field. Yet, we found underrepresentation of non-western countries. There is a need to increase the representation of research participants and researchers from non-western countries through direct initiatives and investments in research and researchers from underrepresented backgrounds.


Social media use and transdiagnostic dimensions of psychopathology: Relative effects of frequency and problematic social media use

November 2024

Background: Young adults in the United States are heavy users of social media which has been identified as a possible risk factor for depression. However, it is unclear whether social media use is associated with internalizing disorder symptom vulnerability beyond depression or whether it is related to other relevant symptom dimensions like externalizing symptoms (e.g., substance use). Moreover, it is unclear what aspects of social media use beyond frequency are associated to symptoms. Methods: A large cohort of undergraduate students from a Midwest university (N= 7123) participated in a screening of transdiagnostic symptoms of psychopathology. Data collected included: time spent on social media, social media platforms used, and aspects of problematic social media use (i.e., use for emotion regulation, compulsive use, or social-media-related impairment). We also collected sociodemographics and self-reported symptoms: depression, panic, generalized anxiety, social anxiety, alcohol use, drug use, insomnia, and pain. We correlated depression scores to time spent on social media to confirm prior findings of an association between social media use and depression. We then used a principal components analysis to identify shared dimensions of psychopathology across these symptoms and explored the correlations between symptom dimensions and elements of social media use. Results: Participants who reported higher social media usage exhibited significantly higher self-reported depression. Our PCA suggested two dimensions of psychopathology consistent with the HiTOP model which we dubbed “emotional” and “externalizing” symptoms. Time spent on social media was correlated with emotional symptoms and with externalizing symptoms, albeit to a lesser extent. However, these associations were not significant after controlling for problematic social media use. Moreover, problematic social media use had differential relations to dimensions of psychopathology. For example, using social media for emotion regulation was associated with more severe internalizing symptoms but less severe externalizing symptoms. E-value analysis suggested that unmeasured confounds could potentially explain these associations. Discussion: Our results suggest that the association between time spent on social media and psychopathology could be accounted for by the way in which social media is used, which in turn is differentially associated to emotional and externalizing symptoms. However, unmeasured confounding remains a threat to these inferences.


Potential Harm in the Psychological Treatment of Sexual and Gender Minority Youth

November 2024

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94 Reads

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2 Citations

Research on Child and Adolescent Psychopathology

Sexual and gender minority (SGM) individuals show disproportionately high rates of mental distress relative to their cisgender, heterosexual peers resulting from minority stress, or unique identity-related stressors. The majority of research on minority stress and mental health in SGM individuals has focused on adults, a notable gap given that SGM youth face unique developmental factors that intersect with identity development and availability of support resources. SGM youth therefore represent a critical population for the mental health workforce to serve competently. Mental health providers risk significant harm to their SGM youth clients if they do not understand the mechanisms underlying mental health disparities in this population. This article will review treatment practices that carry the potential for harm with SGM youth, including harms that are more overt and attempt to change SGM identities (i.e., so-called “conversion therapies”), and others that are more covert, such as neglecting to consider SGM identity in conceptualization and treatment (e.g., eating disorders), pathologizing SGM identity and behaviors (e.g., personality disorders, social anxiety), and reinforcing stigma related to SGM identities (e.g., obsessive-compulsive disorder). Accordingly, this article reviews each of these potential harms in detail and provides alternative recommendations for affirming and justice-based treatment for SGM youth.


Citations (50)


... The findings of substantial heterogeneity in reliability scores based on the mode of administration and the setting, as observed in our meta-analysis, highlight the complexity of deploying a universal screening tool like the PHQ-9 in varied clinical and non-clinical environments. This observation prompts a deeper exploration into how specific cultural and administrative contexts influence the reliability and accuracy of depression assessments, echoing the concerns [55,56]. ...

Reference:

Charting the course of depression care: a meta-analysis of reliability generalization of the patient health questionnaire (PHQ-9) as the measure
Heterogeneity in Item Content of Quality of Life Assessments Used in Depression Psychotherapy Research
  • Citing Article
  • March 2025

... A recent systematic review of mastectomy for young people with gender dysphoria [147] found low or very low certainty evidence pertaining to mental health outcomes, and high certainty evidence that there is at least some increased risk of harm (including necrosis and excessive scarring). An umbrella review also found the evidence pertaining to gender-affirming surgeries in adolescents was of low or very low certainty [131] as did a systematic review [138]. ...

Interventions for Gender Dysphoria and Related Health Problems in Transgender and Gender-Expansive Youth: A Systematic Review of Benefits and Risks to Inform Practice, Policy, and Research
  • Citing Article
  • March 2025

... The established links between distortions and mental health conditions have motivated language analysis on social networks for early detection of depression markers of depression in social media posts (Ophir et al., 2017;Bathina et al., 2021;A. Rutter et al., 2025). Our study underscores that NLP models of cognitive distortions effectively align language with actual mental health conditions, and contributes to real-world monitoring or intervention strategies through advanced detection capabilities. ...

Anxiety and Depression are Associated with More Distorted Thinking on Social Media: A Longitudinal Multi-Method Study

Cognitive Therapy and Research

... First, Pinciotti et al. (2025) outline the potential for harm in sexual and gender minority (SGM) youth on both overt (so-called "conversion therapies") and covert (failure to consider SGM identity in case formulation) levels. Pinciotti et al. also offer recommendations for addressing these issues via promoting affirming and justice-based interventions for SGM youth. ...

Potential Harm in the Psychological Treatment of Sexual and Gender Minority Youth
  • Citing Article
  • November 2024

Research on Child and Adolescent Psychopathology

... Although emotional suppression can reduce an individual's outward expression of emotions, it does not alleviate the subjective experience of negative emotions. Instead, it leads to greater psychological pain [29]. Furthermore, emotional suppression depletes certain cognitive resources, impairs memory capacity, and triggers sympathetic activation of the cardiovascular system, which can lead to the onset of depressive mood [30]. ...

Development and validation of the Emotion Regulation Questionnaire – Positive/Negative (ERQ-PN): Does the target of emotion regulation matter?

... In any case, for these tools to remain available, there appears to be a need to develop sustainable business models. While some participants suggested they would be willing to pay for access to generative AI chatbots, research suggests most users would not 58 , and the path to health insurance funding is not easy 59 . To illustrate the challenge, Inflection, the company behind the Pi chatbot used by most of the participants in our study, pivoted in March 2024 from providing consumer emotional support services towards enterprise AI services, due to a lack of a business model, and despite USD 1.5 billion of investment 60 . ...

Race and Socioeconomic Status as Predictors of Willingness to Use Digital Mental Health Interventions or One-On-One Psychotherapy: National Survey Study

JMIR Formative Research

... Therefore, relying on demographic factors to characterize experiences of discrimination lacks nuance and may lead to incorrect attributions or assumptions. Experiences of discrimination are dynamic and associated with both higher risk for mental health symptoms and capacities for building and using greater resilience [52]. While we are hesitant to overinterpret the moderation findings due to the pilot nature of the current study and the number of exploratory moderation analyses conducted, the emergence of experiences of discrimination as a driver of benefit for depressive or anxious symptoms is a relationship worth exploring in future work. ...

Wider, Faster, More: Reenvisioning Depression Treatment Research in the United States

... Por otro lado, el afecto negativo se asocia a una mayor predisposición a experimentar emociones negativas, afectando a la satisfacción vital y a la calidad de vida (Dufey & Fernández, 2012;Martín et al., 2015). Además, los niveles altos de afecto negativo caracterizan los trastornos de ansiedad y depresión (Rutter et al., 2024). Esta relación entre el afecto y variables psicológicas relacionadas con el bienestar y la salud mental se vuelve más evidente en el contexto educativo. ...

Negative affect variability differs between anxiety and depression on social media

... Another topic of research is the applicability of the A-criterion (i.e., stressor criterion) of the DSM-5(TR) as a gate criterion for PTSD (Howard et al., 2024;Larsen & Pacella, 2016). The discussion of the breadth and usefulness of criterion A is particularly important for people with ID as they appear to be more vulnerable to experiencing traumatic events than their peers without ID (De Vogel & Didden, 2022;Hassiotis et al., 2019;McDonnell et al., 2019). ...

Is a Criterion A trauma necessary to elicit posttraumatic stress symptoms?
  • Citing Article
  • December 2023

Journal of Psychiatric Research

... Utilizing an array of risk indicators, AI holds the potential to estimate an individual's likelihood of developing a mental health disorder and guide them toward appropriate care pathways. These functionalities not only streamline administrative tasks but could also empower both clients and behavioral health practitioners by facilitating referral, triage, and clinical assessment processes, thereby offering precision mental healthcare (Deisenhofer et al., 2024). ...

Implementing precision methods in personalizing psychological therapies: Barriers and possible ways forward

Behaviour Research and Therapy