Löbbert T's research while affiliated with Universitätsklinikum Knappschaftskrankenhaus Bochum and other places

Publications (10)

Article
Full-text available
The aim of the present study was to test the neuroprotective effect of the novel benzothiazol compound lubeluzole on neuronal cell damage in fetal sheep arising from global cerebral ischemia. Thirteen fetal sheep were prepared at a mean gestational age of 127 +/- 1 d (term is at 147 d). Six fetuses were treated with lubeluzole (0.33 mg/kg estimated...
Article
Objective:Asphyxia is one of the main causes of perinatal brain damage that can result in psychomotor, deficits during later development, Recently lubeluzole, a new glutamate antagonist, was shown to improve clinical outcome considerably without any safety concerns in adults who had acute ischemic stroke. However, our preliminary experiments showed...
Article
Full-text available
Asphyxia is one of the main causes of perinatal brain damage that can result in psychomotor deficits during later development. Recently lubeluzole, a new glutamate antagonist, was shown to improve clinical outcome considerably without any safety concerns in adults who had acute ischemic stroke. However, our preliminary experiments showed transient...
Article
Problem: Lubeluzole hat sich in tierexperimentellen Modellen als neuroprotektiv erwiesen. Lubeluzole könnte asphyktische Feten vor einem Hirnschaden bewahren, wenn es keine nachteiligen Effekte auf die Kreislaufzentralisation des Feten im Sauerstoffmangel hat. Deshalb wurden mögliche Wirkungen von Lubeluzole auf die Kreislaufzentralisation unter As...

Citations

... Recently, we were able to show that lubeluzole does not affect fetal circulatory centralization during acute asphyxia. This mechanism is of major importance, because it protects the fetal brain from neuronal injury by increasing blood flow to the central organs, i.e. brain, heart, adrenals, when oxygen is in short supply (15). The present study was performed to clarify whether lubeluzole protects the brain of fetal sheep near term from neuronal cell damage. ...