Lisa States's research while affiliated with University of Pennsylvania and other places

Publications (19)

Article
Full-text available
Purpose To assess and compare the diagnostic accuracy of whole-body (WB) DW-MRI with 2-[¹⁸F]FDG PET for staging and treatment monitoring of children with Langerhans cell histiocytosis (LCH). Methods Twenty-three children with LCH underwent 2-[¹⁸F]FDG PET and WB DW-MRI at baseline. Two nuclear medicine physicians and two radiologists independently...
Article
Pediatric pulmonary malignancy can be primary or metastatic, with the latter being by far the more common. With a few exceptions, there are no well‐established evidence‐based guidelines for imaging pediatric pulmonary malignancies, although computed tomography (CT) is used in almost all cases. The aim of this article is to provide general imaging g...
Preprint
Primary pancreatic tumors in children are rare with an overall age-adjusted incidence of 0.018 new cases per 100,000 pediatric patients. The most prevalent histologic type is the solid pseudopapillary neoplasm followed by pancreatoblastoma. This manuscript describes relevant imaging modalities and presents consensus-based recommendations for imagin...
Preprint
Full-text available
The most common pediatric extragonadal pelvic cancers include germ cell tumors, sacrococcygeal teratomas, and rhabdomyosarcomas (arising from the urinary bladder, prostate, paratesticular tissues, vagina, uterus, and perineum). This manuscript describes the radiological and nuclear medicine features of these entities and provides consensus-based re...
Article
There is a broad differential diagnosis for a pre-pubertal child presenting with a scrotal mass including both benign and malignant etiologies. Lipoblastomas are rare benign neoplasms originating from fat cells that occur most commonly on the trunk or extremities of young children. There have been less than 20 cases of scrotal lipoblastomas reporte...
Article
Objectives: To determine the role of apparent diffusion coefficient (ADC) histogram analysis in the identification of MYCN-amplification status in neuroblastomas. Methods: We retrospectively evaluated imaging records from 62 patients with neuroblastomas (median age: 15 months (interquartile range (IQR): 7-24 months); 38 females) who underwent ma...
Article
Integrated PET/MRI has shown significant clinical value for staging and restaging of children with cancer by providing functional and anatomic tumor evaluation with a 1-stop imaging test and with up to 80% reduced radiation exposure compared with 18F-FDG PET/CT. This article reviews clinical applications of 18F-FDG PET/MRI that are relevant for ped...
Article
Background Longitudinal measurement of tumor burden with MRI is an essential component of response assessment in pediatric brain tumors. We developed a fully automated pipeline for the segmentation of tumors in pediatric high-grade gliomas, medulloblastomas, and leptomeningeal seeding tumors. We further developed an algorithm for automatic 2D and v...
Article
Full-text available
Background Radiologists have difficulty distinguishing benign from malignant bone lesions because these lesions may have similar imaging appearances. The purpose of this study was to develop a deep learning algorithm that can differentiate benign and malignant bone lesions using routine magnetic resonance imaging (MRI) and patient demographics. Me...
Article
18F-DOPA PET/CT was performed to evaluate congenital hyperinsulinism in a 55-day-old boy with hypoglycemia. The images revealed not only a focal 18F-DOPA-avid lesion in the pancreas but also in a left thoracic paraspinal neuroblastoma.
Article
Case: A 5-month-old girl was diagnosed with congenital bilateral absence of the L4 pedicles and an absent right kidney. She developed a right thoracic scoliosis at age 3 that was treated with a brace. At her most recent follow-up at age 16, she was skeletally mature and had a residual 20° right thoracic scoliosis. She was pain-free, had a normal n...
Article
Full-text available
This paper summarizes the 2020 Diversity in Radiology and Molecular Imaging: What We Need to Know Conference, a three-day virtual conference held September 9–11, 2020. The World Molecular Imaging Society (WMIS) and Stanford University jointly organized this event to provide a forum for WMIS members and affiliates worldwide to openly discuss issues...
Article
PURPOSE Many novel therapies for relapsed and refractory neuroblastoma require tumor tissue for genomic sequencing. We analyze our experience with image-guided biopsy in these patients, focusing on safety, yield, adequacy for next-generation sequencing (NGS), and correlation of tumor cell percent (TC%) with quantitative uptake on ¹²³ I-meta-iodoben...
Article
OBJECTIVE. The purpose of this article is to review currently available and emerging techniques for pediatric lung MRI for general radiologists. CONCLUSION. MRI is a radiation-free alternative to CT, and clearly understanding the strengths and limitations of established and emerging techniques of pediatric lung MRI can allow practitioners to select...
Article
Full-text available
Background To develop a deep learning model to classify primary bone tumors from preoperative radiographs and compare performance with radiologists. Methods A total of 1356 patients (2899 images) with histologically confirmed primary bone tumors and pre-operative radiographs were identified from five institutions’ pathology databases. Manual cropp...
Article
e22521 Background: Relapsed and refractory neuroblastoma (NBL) is a prime target for novel therapies targeting specific mutations. The genomic landscape of NBL can change between time of initial diagnosis and relapse, necessitating subsequent biopsy and next generation sequencing (NGS) to detect mutations within the relapsed neoplasm. Tissue of ins...
Article
A hepatobiliary iminodiacetic acid (HIDA) scan is frequently used in an attempt to exclude biliary atresia in infants who are cholestatic. We present 6 cases of confirmed biliary atresia in infants who had biliary patency reported on HIDA scan. We demonstrate that misinterpreted HIDA scans led to delayed diagnosis and surgical intervention for bili...

Citations

... ROC, receiver operating characteristic; PD, proton density; NPC, nasopharyngeal carcinoma; OC, occipital clivus lesions. Ghosh et al. [46] proved that neuroblastomas with MYCN amplification had higher signal intensities (Mean and Maximum) and Energy on ADC map than tumours without MYCN amplification. Zhao et al. [47] also revealed that rectal cancer with lymph node metastasis had both a higher signal intensity (Maximum of the T2 and PD maps) and Energy than cancer without lymph node metastasis. ...
... In addition, for disease staging, a thorough history and physical examination including radiologic imaging is required: chest radiograph for pulmonary disease, complete radiographic skeletal survey for assessment of osseous disease, and abdominal ultrasound for evaluation of liver and/or spleen involvement (10). Recent efforts have tried to conduct required clinical evaluation with one single imaging exam (11). Several investigators reported that magnetic resonance imaging (MRI) has a higher sensitivity for the detection of LCH lesions compared to skeletal surveys (12,13). ...
... A few studies have proposed different DL solutions to the PBT segmentation problem, with whole tumor Dice scores ranging between 0.68-0.76 [17][18][19][20] . These approaches show lower performance than the models proposed for adult brain tumor segmentation, are often only designed for a particular histology, only segment the whole tumor without subregions, or segment the tumors based on one or two MRI sequences. ...
... The manual examination of cancerous images is cost-ineffective due to costly equipment and sometimes results in erroneous results due to the mishandling of details. Machine learning (ML) is now frequently used in cancer research as it provides an easy way to perform data analysis and automated extraction of important information from the data [8]. ...
... These same students have a high dropout rate, lack mentors, and lack knowledge about the variety of careers available to them [17]. Lack of mentorship has been cited as a major contributing factor for the underrepresentation of Black trainees within the field of radiology [18]. ...
... Furthermore, Koshy et al (11) pointed out that FNAB can identify pNT well. Research has also proved the important role FNAB plays in recurrent NB and in guiding clinical surgery and treatment of pediatric solid abdominal tumors (12,13). In this paper, the sensitivity and speci city of biopsy were 88.9% and 100%, respectively, as expected for surgery. ...
... A pilot study of lung MRI in children with interstitial lung disease showed MRI to perform well in the detection of consolidation, parenchymal bands and fissural thickening but less well for findings of septal thickening, ground-glass opacity, nodules and cysts as compared to CT [9]. New MRI techniques, including ultrashort echo time (UTE), improve the depiction of the lung parenchymal anatomy [10]. Functional information regarding lung ventilation revealed by hyperpolarized gas MRI in children with cystic fibrosis could be applied to bronchiolitis obliterans and other obstructive lung diseases but is limited by patient cooperation, the lack of availability of hyperpolarized gas, and expertise in performing this technique at most imaging centers [10]. ...
... Deep learning methods for bone tumor analysis have been explored for other imaging modalities than CT, including X-ray [32,[44][45][46], as well as more costly PET-CT [35] and MRI imaging studies [37][38][39][40]. Unlike our joint approach, most of the existing methods focused on either tumor classification [32,37,38,46] or tumor segmentation [35,39,40]. ...
... Several studies reported variable degrees of sensitivity (84.6-100%) and specificity (61.1-88.6%) for the HBS in diagnosing BA [19][20][21][22][23]. In a large metaanalysis discussing the accuracy of 99mTc-IDA HBS in differentiating BA from NH, Kianifar et al. have reported a pooled sensitivity of 98.7% and a pooled specificity of 70.4%; the reported high sensitivity was due to the extremely rare false negative results recorded [24]. ...