Linjie Xi’s research while affiliated with General Hospital of the Air Force, PLA and other places

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Publications (3)


An agar-polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing
  • Article

August 2022

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40 Reads

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30 Citations

Food & Function

Can Cheng

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Xu Peng

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Linjie Xi

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[...]

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Xixun Yu

Rapid hemostasis, antibacterial effect and promotion of wound healing are the most important functions that wound dressings need to have. In this work, we designed and prepared a hydrogel with antibacterial effect, hemostatic ability and wound healing promotion using agar, polyvinyl alcohol (PVA) and tannic acid (TA). We performed a series of tests to characterize the structure and properties of AGAR@PVA-TA hydrogels. The results showed that the AGAR@PVA-TA hydrogels had good mechanical properties and excellent antibacterial ability as well as good hemocompatibility. The cytotoxicity results showed that the AGAR@PVA-TA hydrogels had good cytocompatibility. And the TA loaded hydrogels also presented some good performances in animal studies. In the liver hemostasis model, the AGAR@PVA-TA hydrogel showed good hemostatic ability. Also, the AGAR@PVA-TA hydrogel was able to promote wound healing in an S. aureus-infected rat wound model. More importantly, our research results demonstrated that compared to other polyphenols (such as proanthocyanidins), TA could better improve the mechanical properties, antibacterial ability and rapid hemostasis of hydrogels, which illustrated the uniqueness of TA. Therefore, the TA loaded hydrogel (AGAR@PVA-TA hydrogel) has the potential to be applied as a wound dressing.


Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine A chilles tendon and its potential application for anterior cruciate ligament repair

August 2022

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17 Reads

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7 Citations

Journal of Biomedical Materials Research Part A

Naringin (Nar), a natural flavanone glycoside, has been shown to possess a variety of biological activities, including anti‐inflammatory, anti‐apoptotic, bone formation, and so forth. In this study, Nar was oxidized by sodium periodate and the oxidized naringin (ONar) was used as a novel biological crosslinking agent. In addition, ONar‐fixed porcine decellularized Achilles tendon (DAT) was developed to substitute anterior cruciate ligament (ACL) for researching a novel ACL replacement material. The ONar with a 24 h oxidation time had appropriate aldehyde group content, almost no cytotoxicity, and a good crosslinking effect. The critical characteristics and cytocompatibility of ONar‐fixed DAT were also investigated. The results demonstrated that 1% ONar‐fixed DAT exhibited good resistance to enzymatic degradation and thermal stability as well as suitable mechanical strength. Moreover, 1% ONar‐fixed specimens exhibited excellent L929 fibroblasts‐cytocompatibility and MC3T3‐E1‐cytocompatibility. They also promoted the secretion of hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF) from fibroblasts and bone morphogenetic protein‐2 (BMP‐2) from osteoblasts. And they also showed the good anti‐inflammatory properties in vivo experiments. Our data provided an experimental basis for ONar as a new cross‐linking reagent in chemical modification of DAT and ONar‐fixed DAT for ACL repair.


Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine Achilles tendon and its potential application for anterior cruciate ligament repair

March 2022

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3 Reads

Naringin (Nar), a natural flavanone glycoside, has been shown to possess a variety of biological activities, including anti-inflammatory, anti-apoptotic and bone formation, etc. In this study, Nar was oxidized by sodium periodate and the oxidized naringin (ONar) was used as a novel biological crosslinking agent. And ONar-fixed porcine decellularized Achilles tendon (DAT) was developed to substitute anterior cruciate ligament (ACL) for researching a novel ACL replacement materials. The ONar with a 24 h oxidation time had appropriate aldehyde group content, almost no cytotoxicity, and a good crosslinking effect. The critical characteristics and cytocompatibility of ONar-fixed DAT were also investigated. The results demonstrated that 1% ONar-fixed DAT exhibited good resistance to enzymatic degradation and thermal stability as well as suitable mechanical strength. Moreover, 1% ONar-fixed specimens exhibited excellent L929 fibroblasts-cytocompatibility and MC3T3-E1-cytocompatibility. They also promoted the secretion of hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF) from fibroblasts and bone morphogenetic protein-2 (BMP-2) from osteoblasts. And they also showed the good anti-inflammatory properties in vivo experiments. Our data provided an experimental basis for ONar as a new cross-linking reagent in chemical modification of DAT and ONar-fixed DAT for ACL repair.

Citations (2)


... It has been found that RES stimulates the production of collagen III and improves the proliferation and migration of human gingival fibroblasts (72). Oxidized NAR exhibited good cytocompatibility and could promote the secretion of growth factors by fibroblasts (73). ...

Reference:

Antimicrobial efficiency and cytocompatibility of resveratrol and naringin as chemical decontaminants on SLA surface
Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine A chilles tendon and its potential application for anterior cruciate ligament repair
  • Citing Article
  • August 2022

Journal of Biomedical Materials Research Part A

... TA increases the mechanical strength, decreases the excessive swelling rate, and promotes the adherence of the hydrogel to various substrates. According to Cheng et al., the combination of PVA and agar loaded with tannic acid presented promising characteristics in terms of hemostatic, antibacterial activity, cytocompatibility, and rapid wound healing [34]. Finally, the composite hydrogel developed in this study can effectively be applied in crucial areas such as artificial cartilage. ...

An agar-polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing
  • Citing Article
  • August 2022

Food & Function