Lingjun Wang's research while affiliated with Guangzhou University of Chinese Medicine and other places

Publications (23)

Article
New findings: What is the central question of this study? Does the AGEs-RAGE axis mediate myocardial fibrosis in heart failure? What is the main finding and its importance? The AGEs-RAGE axis is involved in the pathogenesis of myocardial fibrosis through CFs activation induced by autophagy in heart failure. Inhibiting AGEs-RAGE axis attenuates dys...
Article
Background Heart failure (HF) is a leading cause of death worldwide. Nuanxinkang (NXK) is an effective Chinese herbal formula used in treating HF, but its underlying potential mechanisms have not been fully elucidated. Purpose To explore the protective activities of NXK in ischemia/reperfusion (IR)-induced HF through modulating the ratio of proinf...
Article
Objective Sepsis is a leading cause of morbidity and mortality after surgery. We aimed to explore the role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sponging microRNA-26a-5p in sepsis-induced myocardial injury by regulating regulator of calcineurin 2 (Rcan2). Methods H9C2 cells were incubated w...
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Full-text available
Endothelial-to-mesenchymal transition (EndMT) has been shown to contribute to cardiac fibrosis and heart failure (HF). Recent studies have demonstrated that EndMT is regulated by autophagy, and we previously showed suppression of excessive autophagy and alleviation of cardiac fibrosis in HF mice with inactivated receptor for advanced glycation end...
Article
Ethnopharmacological relevance Xinyang tablet (XYT) has been traditionally used in the treatment of cardiovascular diseases (CVDs). Our previous study indicated that XYT exhibited protective effects in heart failure (HF). Aim of the study The aim of the present study was to determine the protective effects of XYT in pressure overload induced HF an...
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Full-text available
Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a member of MAP3K family, is associated with aging, inflammation, oxidative stress, and related diseases, such as CHF. MLK3 has also been reported to play an important role in...
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Patients with heart disease often suffer from ischemia, which can be treated by reperfusion. However, this treatment can lead to the development of ischemia/reperfusion (I/R) injury, an inflammatory condition that can cause further heart damage. Dexmedetomidine (Dex), an α2-adrenoceptor agonist, and the microRNA (miR)-17-3p, have both been suggeste...
Article
Full-text available
Background: Acupuncture and moxibustion (A&M) has been used for treating heart failure in China since the Han Dynasty. This ancient therapy can be applied to many diseases according to the WHO recommendations. Although there are many clinical reports on the treatment of heart failure by A&M, its effectiveness is still not fully demonstrated. We ai...
Article
Heart failure (HF) is a complex pathology for which single-agent therapy cannot provide comprehensive efficacy. Therefore, effective combination therapies for HF are increasingly emphasized. Multiple-component drugs derived from Chinese herbal formulae provide efficacy and safety when administered to patients with HF. Nuanxinkang (NXK) is a simplif...
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Full-text available
The loss of endothelial connective integrity and endothelial barrier dysfunction can lead to increased vascular injury, which is related to the activation of endothelial inflammasomes. There are evidences that low concentrations of aspirin can effectively prevent cardiovascular diseases. We hypothesized that low-dose aspirin could ameliorate endoth...
Data
Molecular weight markers to gel data and scans in Figure 1C.
Data
Molecular weight markers to gel data and scans in Figure 5A.
Data
(a) PCR Genotyping of RAGE knockout mice. Bands of 380 and 301 bp are derived from the wild-type and knockout alleles, respectively. +/+, wild-type; -/-, homozygous RAGE knockout. (b) Western blot of WT and RAGE KO mice lung tissues using RAGE antibody.
Data
Short axis B-mode of representative echo figure. Scale bars for time and dimensions are listed in lower panel.
Data
Molecular weight markers to gel data and scans in Figure 6A.
Article
Full-text available
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy. However, the role of RAGE in pressure overload-induced HF is not well understood. We found that stimulation of RAGE triggered the death of neonatal rat ventricula...
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Full-text available
Background Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. Methods In this study, we seeded Isl1+ embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestin...
Article
Full-text available
The cyclic nucleotide phosphodiesterase (PDE) plays an important role in regulating the levels of second messenger molecules cAMP and cGMP. Various PDE inhibitors have been successfully developed into drugs for targeted diseases. In addition, PDE inhibitors can also be found in different foods and natural medicines. In this study, ultrafiltration l...
Data
The retention times and MS data of the extract, ultrafiltrate and standard compound were summarized (Table S1). The EIC chromatograms of each compound in negative ion mode of the extract, ultrafiltrate, and blank sample were shown (Figures S1–9).
Article
Pressure overload has an important role in heart failure, inducing excessive autophagy in cardiac myocytes that is considered to be pathogenic. Resveratrol has been reported to improve cardiac dysfunction induced by pressure overload, but it has been unclear whether resveratrol ameliorates cardiac dysfunction by regulating autophagy. In this study,...

Citations

... The RAGE axis is involved in rheumatoid arthritis (192), systemic lupus erythematosus (193), amyotrophic lateral sclerosis (194), inflammatory bowel disease (195), depression (196) and other diseases. In addition, RAGE is involved in the fibrotic process in several organs, such as hepatic fibrosis (19), cardiac fibrosis (197), pulmonary fibrosis (198) and renal fibrosis (199) (Figure 2). ...
... MMP2 and MMP9 play an important role in degrading basement membranes, allowing neutrophil (PMN) migration and promoting inflammation [23,24]. In many diseases, MMP2, MMP9, and pyroptosis indicators change in parallel, but it is unclear how they are related to each other [25][26][27][28]. However, whether an association exists between them in LIRI has rarely been studied. ...
... [46] Heart Oxidative damage MLK3-JNK/p53 pathway-mediated oxidative stress and ferroptosis cause myocardial fibrosis. [111] Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling. [113] Elabela antagonizes ferroptosis by regulating the IL-6/STAT3/GPX4 signaling pathway to prevent adverse myocardial remodeling. ...
... Dexmedetomidine (DEX) is a highly selective α2-adrenergic receptor agonist, which protects against H/R damage and lessens the percentage of apoptotic cells [42]. Reports have claimed that DEX has strong anti-inflammatory properties and is able to reduce I/R-induced cardiomyocyte injury by suppressing inflammatory signaling [43]. Additionally, DEX prevents H/R-induced myocardial injury by improving oxidative stress and apoptosis [33]. ...
... Furthermore, acupuncture and MOX have been widely applied to treat hyperlipidemia in clinical practice (39). In addition, the combination of acupuncture and MOX could improve cardiac function of patients with HF in clinical practice (40). In the present study, MOX increased the levels of indicators of cardiac function (e.g., BNP, LVIDS, EF and FS) and attenuated myocardial fibrosis. ...
... It is composed of Radix ginseng Rubra (Hong Shen) and llex pubescens (Mao DongQing). Our preclinical study showed that NXK has an anti-apoptotic effect against CHF, which is mediated by the AKT signaling pathway (Chen et al., 2019). Another study showed that combination therapy with NXK and basic CHF treatment effectively improved cardiac function in CHF patients compared to basic CHF treatment alone. ...
... The work of Takeshi et al. showed that targeting the early inflammatory response induced by CM CaMKIId (Ca 2+ /calmodulin-dependent protein kinase II d) signaling could prevent progression to heart failure (191). Another study showed that aspirin exerts a protective effect against cardiovascular disease by inhibiting the activation of NLRP3 in vascular endothelial cells (192). ...
... BNIP3/NIX is significantly increased after receiving TAC [126]. Knockout of the RAGE prevented the upregulation of BNIP3 in TAC mice and improved TAC-induced cardiac dysfunction [127]. Another study showed that raloxifene is a novel IL-6 inhibitor that can inhibit IL-6-induced BNIP3 elevation as well as cardiac dysfunction and remodelling caused by pressure overload [128]. ...
... Studies from multiple research groups have established promising strategies to trigger cardiac repair and heart regeneration, including direct reprograming non-myocytes to cardiomyocytes, activation of cardiomyocyte proliferation, as well as stem-cell based therapies (Cahill et al., 2017;Chien et al., 2019). ISL1 + CPCs derived from pluripotent stem cells are actively investigated for cardiac repair in recent years (Bartulos et al., 2016;Li et al., 2017;Wang et al., 2017;Foo et al., 2018;Ghazizadeh et al., 2018). Defining the molecular mechanisms underlying normal cardiovascular development is a prerequisite for understanding the etiology of cardiovascular diseases. ...
... Flavonoids and phenolic acid are the main constituents of EMEA, supporting our previous colorimetric quantification and enhancing our hypothesis on the relationship between phytochemicals and activities. Thereafter, EMEA was subjected to the bio-affinity UF-UPLC-QTOF-MS/MS, an efficient method recently used by several researchers for the depiction of bioactive compounds within a complex mixture for finding ligands to a specific enzyme target [4,37]. After processing, the peak areas discrepancy of the chromatograms of those incubated with active and inactive enzymes was clearly visible as illustrated in Fig. 4. ...