Ling Li’s research while affiliated with First Affiliated Hospital of China Medical University and other places

... Three lncRNAs, including lncND5, lncND6, and lncCytb, were first reported by Filipovska's group [32]. These lncRNAs have been reviewed in several reports [33][34][35]. We identified lncND5, comprising 1806 nucleotides (Supporting Information File 1), located on chromosome M:12314-14115 ( Figure 1A) using the National Center for Biotechnology Information and University of California Santa Cruz Genome Browser. ...

Reference:

Mitochondrial Genome‐Encoded lncND5 Regulates Mitophagy in Hypoxic Pulmonary Artery Smooth Muscle Cell

... For example, nucleosides serve as quality control markers and exhibit anti-inflammatory, anti-cancer, anti-fibrotic, and cardioprotective effects, while polysaccharides and peptides can modulate immune cell activities and protect against oxidative injury. 4,[12][13][14][15][16][17][18] Modern pharmacological studies have demonstrated that Cordyceps sinensis and its constituents possess antioxidative, immune-regulating, and metabolic-regulating properties. 4,[19][20][21][22] Air pollution, dust, soot, trauma, and infection are important causes of lung diseases. ...

Reference:

Cordyceps Sinensis Reduces Inflammation and Protects BEAS-2B Cells From LPS-Induced THP-1 Cell Injury

... • Step 3. Evidence from RCTs and NRSIs may be presented as narrative syntheses, quantitative analyses, or a combination. If it is possible to combine RCTs and NRSIs in the same meta-analysis, we recommend that advanced statistical approaches that allow for bias corrections are the preferred method for quantitative analysis, rather than traditional metaanalysis [16,33,[38][39][40]. • Step 4. We encouraged authors to explore the sources of heterogeneity, highlight differences between included RCTs and NRSIs, and discuss their impact on the direction and magnitude of pooled estimates. ...

Reference:

Integration of non-randomized studies with randomized controlled trials in meta-analyses of clinical studies: a meta-epidemiological study on effect estimation of interventions

... In recent years, traditional Chinese herbal medicine has been widely applied to treat AP and is considered a significant nonsurgical treatment option, with its efficacy validated through both clinical practice and basic research Deng et al., 2024;Li et al., 2024). Tetramethylpyrazine (TMPZ), an active alkaloid monomer primarily purified from the tubers of herbs such as Curcuma, Jatropha, and Ligustrum, possesses a defined chemical structure and exhibits multiple therapeutic effects (Qi et al., 2024), including anti-inflammatory action, reactive oxygen species scavenging, lipid peroxidation inhibition, microcirculatory improvement, and immunomodulation. ...

Reference:

Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway

... Numerous studies and clinical trials have been conducted on this topic. Recent systematic reviews and meta-analyses suggest that ACP significantly improves neurological function, reduces disability, and enhances daily living activities in patients with acute stroke (Zhang et al. 2005;Zhong et al. 2024). However, most of these studies report only low to moderate certainty of the evidence. ...

Reference:

The benefit of early acupuncture within 7 days for neurological outcomes in ischemic stroke patients after cardiac surgery

... Therefore, strategies aimed at targeting FBXW7 may offer potential therapeutic approaches for cancer treatment. Although no drugs currently directly target FBXW7, promising therapeutic strategies have been proposed based on existing research (Zeng et al., 2024). Future treatments may focus on restoring or replacing FBXW7 expression by targeting its upstream regulators, such as MiRNA and ERK, or by inhibiting downstream oncoproteins such as MCL-1, mTOR, and c-Myc Eto et al., 2015;Ma et al., 2013;Ruan et al., 2024;Gao et al., 2020). ...

Reference:

FBXW7 in gastrointestinal cancers: from molecular mechanisms to therapeutic prospects

... An in vitro simulated fermentation model demonstrated that APS raised the levels of alltrans retinoic acid, thiamine, glutamine, and propionic acid in the feces sample of Type II diabetes mellitus patients, while lowering the levels of L-threonine, L-valine, L-proline, and spermine. This helped regulate processes like aminoacyl-tRNA biosynthesis, butyric acid metabolism, and thiamine metabolism, thereby increasing the populations of beneficial bacteria such as Bifidobacterium bifidum and Lactobacillus lactis while decreasing the population of potentially harmful bacteria such as Escherichia-Shigella (Zhang et al. 2024c). ...

Reference:

Polysaccharides, saponins and flavonoids in Astragali Radix: a review of phytochemistry and pharmacology for future therapeutic applications

... • Step 3. Evidence from RCTs and NRSIs may be presented as narrative syntheses, quantitative analyses, or a combination. If it is possible to combine RCTs and NRSIs in the same meta-analysis, we recommend that advanced statistical approaches that allow for bias corrections are the preferred method for quantitative analysis, rather than traditional metaanalysis [16,33,[38][39][40]. • Step 4. We encouraged authors to explore the sources of heterogeneity, highlight differences between included RCTs and NRSIs, and discuss their impact on the direction and magnitude of pooled estimates. ...

Reference:

Integration of non-randomized studies with randomized controlled trials in meta-analyses of clinical studies: a meta-epidemiological study on effect estimation of interventions

... The composition and diversity of the gut microbiome are crucial for immune regulation and have been linked to an increased risk of developing atopic diseases including FAs [8][9][10]. Evidence supporting the importance of normal development of the gut microbiome to prevent atopic diseases includes associations between cesarean delivery (compared to vaginal delivery), breastfeeding or maternal diet, and allergy risk in the offspring [11,12]. ...

Reference:

The impact of neonatal antibiotic exposure on the development of childhood food allergies

... However, these methods face limitations in complex grinding processes due to nonlinear dynamics between parameters and desired results. Adaptive design of experiments (ADoE) dynamically adjusts experimental parameters based on outcomes from earlier trials, significantly reducing the number of tests required [25][26][27]. This approach contrasts with traditional DoE, which relies on a predetermined and unchanging set of conditions throughout the process [28]. ...

Reference:

Knowledge-Based Adaptive Design of Experiments (KADoE) for Grinding Process Optimization Using an Expert System in the Context of Industry 4.0