Ling-Bo Qu's research while affiliated with Zhengzhou University and other places

Publications (215)

Article
3-(2-(Ethynyl)phenyl)quinazolinones were designed and synthesized as a class of novel and efficient skeletons for phosphorylation/cyclization reactions. Under visible light irradiation, a series of phosphorylated quinolino[2,1-b]quinazolinones (35 examples, up to 87% yield) were first synthesized from 3-(2-(ethynyl)phenyl)quinazolinones and diarylp...
Article
A visible-light-induced persulfate-promoted cascade phosphorylation/cyclization reaction to access various phosphorylated pyrrolo[1,2-a]indolediones under mild conditions was developed. Notably, the transformation was carried out with diethyl carbonate/H2O as a green medium at room temperature. More impressively, traditional metal catalysts and pho...
Article
A photocatalytic strategy for the controllable aroylation or diaroylation of allyl sulfones was established using tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst and aldehydes as radical precursors. By adjusting the substrate ratio, the selectivity of the reaction could be readily tuned and various aroyl gro...
Article
DFT calculations were performed to reveal the regioselectivity for the sulfonylation of tetrazoles. By comparing the substituent effect of tetrazoles, we found that the regioselectivity depends mainly on the steric hindrance of the substituent and is less affected by its electronic properties. In this work, molecular orbital analysis, the geometric...
Article
The possible mechanisms of [4 + 3] cyclization of N,N′-cyclic azomethine imine with isatoic anhydride catalyzed by a Brønsted acid catalyst have been investigated by performing DFT calculations. The calculated results show that the most energetically favorable pathway mainly includes (1) nucleophilic attack on isatoic anhydride, (2) the decarboxyla...
Article
Covalent organic frameworks (COFs) are an ideal template for photocatalytic H2O2 synthesis because of the tunable chemical structures and semiconductor properties. However, the photoactivity for COFs is still under-improved due to the inefficient intrinsic charge generation, fast recombination of photogenerated charges, and limited electron transpo...
Article
A visible-light-induced metal-free cascade cyclization of cyclic N-sulfonyl ketimines with N-arylglycines for the construction of N-sulfonamides-fused imidazolidines was developed. The procedure employed 3 mol% of eosin Y as photocatalyst at...
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General photoactivation of electron donor-acceptor (EDA) complexes between arylsulfonium salts and 1,4-diazabicyclo[2.2.2]octane with visible light or natural sunlight was discovered. This practical and efficient mode enables the production of aryl radicals under mild conditions, providing an unrealized opportunity for two-step para-selective C-H f...
Article
In this work, the antibacterial activity and mechanism of chloroform fraction obtained from aqueous extract of mugwort leaves against Staphylococcus aureus (S. aureus) were investigated. The extract showed obvious antibacterial activity against S. aureus which the minimum inhibitory concentration and minimum bactericidal concentration were determin...
Article
A general visible-light-induced catalyst-/additive-free strategy was developed for the construction of various aroylated heterocycles (55 examples, up to 95% yield, including modification of pharmaceuticals and natural products) such as thioflavones, benzimidazo[2,1-a]isoquinolin-6(5H)-ones, indolo[2,1-a]isoquinolin-6(5H)ones, quaternary 3,3-dialky...
Article
A practical and efficient synthetic route to construct a variety of 3-arylselenenyl/3-arylthio spiro[4.5]trienones was developed using Selectfluor reagent as a mild oxidant. This reaction proceeds via a sequence of electrophilic cation addition, spirocyclization and dearomatization, then offers an approach to introduce Se/S-centered cation into the...
Article
In present study, a novel glutathione functionalized MoS2 quantum dots (GSH-MoS2 QDs) was synthesized from sodium molybdate dehydrate and glutathione by using a one-pot hydrothermal method. After they were characterized, the influence of GSH-MoS2 QDs on amyloid aggregation of bovine serum albumin (BSA) was investigated by various analytical methods...
Article
A general and metal-free visible-light-induced decarboxylative arylation procedure at room temperature was described for the construction of acylated heterocyclic derivatives, such as benzimidazo/indolo[2,1-a]isoquinolin-6(5H)-ones, aroylazaspiro[4.5]trienones, thioflavones, and so on. This practical arylation procedure was conducted by using 2,4,5...
Article
A facile “plug-and-go” strategy for the fabrication of Janus membranes (JMs) is proposed that uses different combinational substrates with opposite wettability, and some suitable substrates are tightly integrated through a certain pressure. The excellent compactness and controllability of the optimal JMs using foam Ni and superhydrophilic Cu mesh a...
Article
Although breakthroughs in the N-heterocyclic carbene (NHC)catalyzed inert C−C bond activation strategy have been achieved, understanding the role of the catalyst as well as the origin of its chemo- and stereoselectivities is still one of the most challenging questions in the field of organocatalysis. Herein, we propose an NHC and NHC·H⁺ cooperative...
Article
Weaning is the gradual process of introducing solids or semisolid foods into an infant's diet, in order to ensure their healthy growth. This study developed two kinds of formula weaning food based on roasted or extruded quinoa and millet flour, and evaluated their quality. A fructo‐oligosaccharide (FOS)/galacto‐oligosaccharide (GOS) mix was added t...
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An easily prepared phosgene probe, 5′-amino-2-(2′-hydroxyphenyl)benzimidazole ( P1 ), is designed and studied. Based on ESIPT mechanism, P1 exhibits ratiometric, sensitive and selective detection of phosgene both in solution and gas phase.
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Targeted release of anticancer drugs to tumor sites has a pivotal role in clinical oncology. pH-responsive drug delivery systems, with an intelligent and targeted release of anticancer drugs in a controllable manner based on sensitivities to the weakly acidic environments of tumor cellular microenvironments, are desirable. Herein, the design of suc...
Article
2,4,5,6-Tetrakis(3,6-di-tert-butyl-9H-carbazol-9-yl)isophthalonitrile (4CzIPN- t Bu) was developed as a photocatalyst for the phosphorus-radical-initiated cascade cyclization reaction of isocyanides. By using 4CzIPN- t Bu as catalyst, we developed a visible-light-induced proton-coupled electron transfer strategy for the generation of phosphorus-cen...
Article
Through direct coupling reaction of azine N‐oxides with readily available pyridin‐2(1H)‐ones, a facial and practical strategy was developed for the synthesis of 1‐azine‐pyridin‐2(1H)‐one derivatives in the presence of diethyl H‐phosphonate, CCl4 and Et3N at room temperature for 0.5 h. This reaction features metal‐free and mild reaction conditions,...
Article
Resveratrol and oxyresveratrol are two natural polyhydroxy trans-stilbene products. Previous studies have shown that both of them can effectively inhibit the activity of tyrosinase. However, little attention has been paid to study the difference of their inhibitory mechanism. To reveal this difference, in this work a comparative study on the inhibi...
Article
Regulating the reactivity of nucleophiles is important in synthetic chemistry. As a weaker nucleophile is also a stronger Brønsted acid, it can be selectively deprotonated by a Brønsted base to give an anionic species that shows higher reactivity. Following this idea, the reactivity of nucleophiles can be controlled by using an appropriate Lewis ac...
Article
This study determined the effects of four thermal processing methods for germinated highland barley (GHB) on its nutritional composition, physicochemical properties, in vitro starch and protein digestibility, and in vitro prebiotic effects. The contents of total dietary fiber (TDF) and total phenols were significantly increased by steaming, microwa...
Article
A metal-free and base-free procedure for the phosphorylation of imidazo[1,2-a]pyridines with phosphine oxides under the irradiation of visible light at room temperature in green solvent was reported, featuring mild and sustainable conditions, convenient operation, as well as good functional group compatibility.
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Pentachlorophenol (PCP), commonly used as a wood preservative, pesticide, and fungicide, is the most toxic of all chlorophenols and can accumulate in living organisms. It is of great significance to construct a sensitive method for the detection of PCP in real samples. In this study, a simple, novel, and sensitive electrochemical sensor for pentach...
Article
A taxonomic identification using a polyphasic approach was performed on strain NBS58-1 T , which was isolated from the interfacial sediment of Taihu Lake in China. Strain NBS58-1 T was Gram-stain-negative, aerobic, non-spore-forming and catalase-positive. Phylogenetic analyses based on 16S rRNA gene and three housekeeping genes ( rpoB , gyrB and dn...
Article
Three new CdII coordination polymers (CPs) have been synthesized by hydrothermal reactions of Cd(OAc)2, 1,2,5‐thiadiazole‐3,4‐dicarboxylic acid (H2tdzdc), and distinct N/O‐donor ligands. They exhibit two‐dimensional (2D) and three‐dimensional (3D) structures with different topology networks including rob, zzx, and cem. The introduction of 4,4‐bipyr...
Article
Monitoring Zn2+ in living cells is critical for fully elucidating the biological process of apoptosis. However, the quantitative intracellular sensing of Zn2+ using DNAzyme remains challenging because of issues related to penetration of the signal through tissue, targeted cellular uptake and activation, and susceptibility toward enzymatic degradati...
Article
A feasible arylaminomethyl radical-triggered tandem annulation reaction has been developed toward a large variety of poly fused heterocycles, tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones, by reacting diverse quinoxalin-2(1H)-ones with various N-arylglycines in green solvent (DMC) in the presence of CsPbBr3 under white-light irradiation conditions.
Article
A novel strain, designated NS18 T , was isolated from sediment sampled at Taihu Lake, PR China. Cells of the isolate were spherical, aerobic, non-motile, Gram-stain-positive and non-endospore-forming. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain NS18 T clustered in a clade of the genus Agrococcus . Its closest phyloge...
Article
An effective and simple visible light-induced heterogeneous g-C3N4-catalyzed decarboxylative reaction of quinoxalin-2(1H)-ones with N-aryl glycines was developed. When the reaction was performed in DMSO/H2O and EtOH, the products dihydroquinoxalin-2(1H)-ones and tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones were unprecedentedly obtained in good yie...
Article
The flexible and conductive carbon dots (CDs)/MXene films with 0D/2D dot-sheet motif architectures are successfully fabricated via the Coulombic interaction between negatively charged Ti3C2Tx MXene nanosheets and positively charged CDs synthesized from biomass by a green and economic one-pot hydrothermal process. The interlayer spacing coupled with...
Article
Full-text available
Generally, N-heterocyclic carbene (NHC) complexed with carbonyl compounds would transform into several important active intermediates, i.e., enolate, Breslow intermediate, or acylazolium intermediate, which act as either a nucleophile (Nu) or an electrophile (E) to react with the other E/Nu partner. Hence, the key for predicting the origin of chemo...
Article
Carbon dots (CDs) has been widely studied for its excellent properties. However, most of the prepared CDs only show strong emission in blue to green region, which greatly limits the application of CDs in the biomedical field. In this report, a new design strategy of long wavelength CDs was reported. The orange phenyl-CDs with good optical propertie...
Article
The possible mechanisms and origin of selectivities in N-heterocyclic carbene (NHC)-catalyzed reactions of an aliphatic ester with aminochalcone were studied using density functional theory. Herein, a general mechanistic map involving various types of possible intermediates was discovered, and the corresponding chemoselective pathways were systemat...
Article
Ir catalysis is widely used in hydrogenation reactions to transform unsaturated molecules to the corresponding saturated molecules. Understanding the reaction mechanism is helpful for design of new Ir-catalyzed hydrogenation reactions, as well as for controlling the regio/stereoselectivity. Density functional theory is a powerful tool for mechanist...
Article
Monitoring the ATP levels in lysosomes in situ is crucial for understanding their involvement in various biological processes but remains difficult due to the interference of ATP in other organelles or the cytoplasm. Here, we report a lysosome-specific fluorescent carbon dot (CD), which can be used to detect ATP in acidic lysosomes with “off-on” ch...
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Full-text available
Any solid surface with homogenous or varying surface energy can spontaneously show variable wettability to liquid droplets with different or identical surface tensions. Here, we studied a glass slide sprayed with a quasi-superamphiphobic coating consisting of a hexane suspension of perfluorosilane-coated nanoparticles. Four areas on the glass slide...
Article
In this study, the effect of a glycoprotein obtained from Fupenzi (FPZ) (Rubus chingii Hu.) on the fibrillation of bovine serum album (BSA) was investigated by multi-spectroscopic methods and transmission electron microscopy. Moreover, the cytotoxicity of the glycoprotein and the effect of it on H2O2-induced cell viability were investigated by cell...
Article
Tanreqing injection is a Chinese medical formula used to treatment of respiratory diseases. In our study, we developed a feasible and accurate strategy applying an ultra-high-performance liquid chromatography coupled with Q Exactive™ Plus-Orbitrap Fusion mass spectrometers (UPLC-Q-Orbitrap Fusion MS/MS) to clarify and quantify the chemical profilin...
Article
An aerobic, Gram-stain-negative, non-spore-forming and rod-shaped bacterial strain, designated N8T, was isolated from the interfacial sediment of Taihu Lake in PR China. The strain formed white to blue colonies on R2A agar. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain N8T represented a member of the genus Gemmobacter an...
Article
A sustainable and cost‐effective protocol for direct aminomethylation of imidazo‐fused heterocycles by decarboxylative coupling reaction of N‐phenylglycines with imidazo‐fused heterocycles in the presence of CsPbBr3 under the irradiation of visible light has been developed. This is the first example of CsPbBr3‐catalyzed aminomethylation of imidazo‐...
Article
DNA amplification is a useful technique for low-abundance biomarker detection and environmental monitoring due to its high signal-amplifying ability. However, intracellular application of DNA amplifiers remains challenging due to poor delivery efficiency and stability. Herein, we report an entropy-driven DNA amplifier-functionalized metal-organic f...
Article
Aggregation-induced emission luminogens (AIEgens) with a large electron donor and acceptor (D-A) conjugated system have been widely used in the development of organic light emitting diodes (OLEDs), chemosensors and bioimaging materials due to their excellent properties such as high quantum yields, long emission wavelengths, controllable luminescenc...
Article
The regioselectivity of hydroacylation mediated by transition metal and organocatalyst has been and continues to be one of the most challenging questions in the synthesis field. To explore the possible mechanisms and origin of the regio-/enantioselectivity, the density functional theory (DFT) calculations were performed for studying intramolecular...
Article
A Mn(III)‐mediated radical cyclization reaction of o‐vinyl arylisocyanides and arylboronic acids or diphenylphosphine oxides to access various 2‐funtionalized quinolines under mild conditions was developed. With the introduction of radical stabilizing substituents (e.g. aryl and methyl group) on vinyl group, this reaction provides a regiospecific 6...
Article
A novel bacterial strain, designated NS28T, was isolated from interfacial sediment sampled at Taihu Lake, PR China. Cells were rod-shaped, Gram-negative, aerobic and non-motile on Reasoner's 2A medium. The results of phylogenetic analysis based on 16S rRNA gene sequences indicated that strain NS28T was most closely related to species from the genus...
Article
The introduction of phosphorus functional groups into the skeleton of thioflavones is an attractive task and of great significance. Herein, a metal-free visible-light-induced radical cascade cyclization was developed for the preparation of 2-phosphorylated thioflavones from methylthiolated alkynones and phosphine oxides. In water as a green reactio...
Article
The mechanisms of N‐heterocyclic carbene (NHC)‐catalyzed dearomatization reaction of alkyl pyridinium have been intensively studied using the density functional theory (DFT) method. The chemoselectivity and stereoselectivity were both analyzed based on the established mechanisms. The computational results showed that the chemoselective C4‐addition...
Article
An efficient and convenient silver‐catalyzed procedure was developed for the synthesis of various phosphoryl‐substituted benzimidazo[2,1‐a]isoquinoline‐6(5H)‐ones from diarylphosphine oxides and 2‐arylbenzoimidazoles. Moreover, the phosphoryl‐substituted indolo[2,1‐a]isoquinolin‐6(5H)‐ones could also be achieved by using this strategy under mild re...
Article
An efficient and simple protocol for Selectfluor‐mediated phosphonation of quinoxalin‐2(1H)‐ones with dialkyl H‐phosphonates has been developed under base and transition‐metal free conditions, affording the desired 3‐phosphorylated quinoxalin‐2(1H)‐ones in good to excellent yields. This method has the advatages of broad substrate scope, general fun...
Article
An efficient and practical one‐pot strategy for the synthesis of N ‐sulfonylformamidines was developed by directly using easily available sulfonyl chlorides, sodium azide and tertiary/secondary amines in the presence of 5 mol% CuBr 2 under aerobic oxidative conditions.
Article
As a novel type of bifunctional catalyst, the Lewis acid‐transition metal (LA‐TM) catalysts have widely applied for hydrogen activation. This study presents a mechanistic framework to understand the LA‐TM catalyzed H2 activation via DFT studies. The mer(trans)‐homolytic cleavage, the fac(cis)‐homolytic cleavage, the synergetic heterolytic cleavage,...
Article
The Rh(III)-catalyzed reactions of α,β-unsaturated oximes with alkenes are versatile methods for the synthesis of pyri-dines. Density functional theory (DFT) calculations reported here reveal the detailed mechanism and origins of selec-tivity in this reaction. The Rh(III)/Rh(V)/Rh(I) catalytic cycle was found to be more favorable than the previousl...
Article
Previously reported copper oxide-based cathodic photoelectrochemical bioanalysis of cysteine had attributed the decrease of the photocurrents to the binding of cysteine onto the CuO surface. However, our latest investigation found that previous explanation was not that correct. This Letter presented the in-depth study of such phenomena and a new in...
Article
Carbon dots (CDs) are emerging as powerful tools for biosensing and bioimaging because of their intrinsic properties such as abundant precursors, facile synthesis, high biocompatibility, low cost and particularly robust tunability and stability. In this paper, a new type of CDs was prepared from m-phenylenediamine and folic acid by hydrothermal met...
Article
A novel and practical fluoroalkyl radical-initiated cascade reaction was developed to access diverse 2-fluoroalkylbenzothiazoles by reacting various fluoroalkyl radical sources, including perfluoroalkyl iodide (IC nF2 n+1, n = 3-8, 10), ICF(CF3)2, ICF2COOEt, ICF2CF2Cl, or ICF2CF2Br, tetramethylethane-1,2-diamine (TMEDA), and 2-isocyanoaryl thioethe...
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Full-text available
(1) Background: Rhubarb anthraquinones—a class of components with neuroprotective function—can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect plasm...
Article
Regio‐ and stereo‐divergent construction of carbon‐fluorine bond remains a challenge in fluorine chemistry, especially reactions involving fluorination at the α‐position of a carbonyl group. Herein, we present a detailed study for predicting the origins of regio‐ and stereo‐selectivity for organocatalyst catalyzed fluorination reaction. Possible me...
Article
Predicting the chemoselectivity of [2 + 2] cyclizations is an important challenge in organic chemistry. Herein we provided a valuable case for this issue. Density functional theory (DFT) calculations were performed to systematically study the possible mechanisms and origin of selectivities for the N-heterocyclic carbene (NHC)-catalyzed oxidative α-...
Article
The possible mechanisms and origin of the enantioselectivity of the reaction between 2H‐azirine and an aldehyde catalyzed by an N‐heterocyclic carbene (NHC) were theoretically studied and predicted at the M06‐2X/6‐31G(d,p)/IEF‐PCMMTBE//M06‐2X‐GD3/6‐311++G(2df, 2pd)/IEF‐PCMMTBE level. The most favorable reaction pathway consists of four steps, i.e.,...
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Superamphiphobic surfaces generally need a specific combination of low surface energy and re-entrant surface structure. Herein, we have created a hexane suspension of trichloro(1H,1H,2H,2H-tridecafluoro-n-octyl) silane, tetraethyl orthosilicate, silicon dioxide and titanium dioxide nanoparticles and modify a series of filter papers by one-step imme...
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Polymerization-induced phase separation is comparatively applied to fabricating a superhydrophobic micro/nano surface by microwave and ultraviolet (UV) irradiation. The monolithic coatings can be tailored easily on different substrates with excellent chemical and mechanical stability in rigid conditions. Importantly, the patterned filter paper is s...
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Background Mount evidence from observational studies suggested that associations between sleep duration and the risks of mild cognitive impairment (MCI)/dementia or cognitive decline had been recognized. Methods To explore the precise and continuous effect of sleep duration on these risks, we conducted a dose–response meta-analysis to quantitativel...
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Membrane-based metal substrates with special surface wettability have been applied widely for oil/water separation. In this work, a series of copper foams with superhydrophobicity and superoleophilicity were chemically etched using 10 mg mL−1 FeCl3/HCl solution with consequent ultrasonication, followed by the subsequent modification of four sulfhyd...
Article
Density functional theory (DFT) can be used to study the three‐center two‐electron (3c2e) bonding mode, which is universal in catalysts containing alkaline‐earth (Ae) and boron‐group (Bg) elements. However, because of the delocalization pattern of the 3c2e bond, the wavefunction cannot be accurately described by DFT methods. The calculated energies...
Article
The novel base‐controlled mechanisms for N‐heterocyclic carbene (NHC)‐catalyzed divergent [3 + 3] and [3 + 2] annulation reactions were examined by using DFT method. The reaction initiates with the complexation of NHC and enal to give the Breslow intermediate, which diverges afterward. Then, the azomethine imine can either react with Breslow interm...
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Full-text available
The readily accessible and inexpensive dialkyl H -phosphonates are important building blocks for organic synthesis. This review specifically covers our recent work on the application of H -phosphonates as reactants for C–P bond formation, and as promoters for quinoline N -oxides to synthesize 2-functionalized quinolines.
Article
An efficient copper-catalyzed radical cascade cyclization strategy was developed, by which a wide variety of 3-sulfonyl substituted indenones were prepared in one-pot via reaction of 2-alkynylbenzonitriles with sulfonyl hydrazides in the presence of TBHP and CuI under mild reaction conditions. Much more importantly, the 3-sulfonyl indenones, synthe...