Lin Yang’s research while affiliated with First Affiliated Hospital of China Medical University and other places

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Publications (12)


Survey questionnaire.
Association between the duration of UDCA administration and the disease. The darker the red, the closer the connection.
Characteristics of COVID-19 manifestations in general population. Red indicates manifestation characteristics after infection, blue indicates manifestations that are still present 2 weeks after infection, and green indicates manifestations that are still present 4 weeks after infection. Numbers indicate frequency of occurrence.
Characteristics of COVID-19 manifestations in individuals taking UDCA. Red indicates manifestation characteristics after infection, blue indicates manifestations that are still present 2 weeks after infection, and green indicates manifestations that are still present 4 weeks after infection. Numbers indicate frequency of occurrence.
The Role of Ursodeoxycholic Acid Administration During the COVID-19 Pandemic: A Questionnaire Survey
  • Article
  • Full-text available

January 2025

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10 Reads

Cheng Zhou

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Ran Jia

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Jinqiu Yang

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Wenxia Zhao

In December 2022, China classified COVID-19 as a category B infectious disease. This ended 2 years of close epidemiological surveillance of COVID-19. The objective of this questionnaire was to assess the infection status in the COVID-19 pandemic since December in Henan Province, China, and the prevalence of infection in people who were taking ursodeoxycholic acid (UDCA) during this period. We distributed questionnaires to patients attending the gastroenterology clinic at the First Affiliated Hospital of Henan University of Chinese Medicine. The questionnaire lasted for 3 weeks and a total of 660 were collected, of which the number of people taking UDCA was 70. This is the first investigation into the rate of infection among those taking UDCA during the time of the COVID-19 pandemic. Our results showed that the overall infection rate among those taking UDCA was 71.43% (n = 50), with a 10% (n = 7) rate of asymptomatic infections, which was significantly lower than the 85.42% (n = 504) and 6.27% (n = 37) rates among respondents who did not take. The administration of UDCA showed a trend toward reducing the rate of COVID-19 infection, but the difference was not statistically significant when compared to patients with shorter durations of medication use. While less than 30% of participants remained uninfected during the study period, indicating a potential protective effect, it is important to note that complete prevention of SARS-CoV-2 infection by UDCA was not observed.

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Convergent application of traditional Chinese medicine and gut microbiota in ameliorate of cirrhosis: a data mining and Mendelian randomization study

November 2023

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49 Reads

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7 Citations

Objective Traditional Chinese medicine (TCM) has been used for the treatment of chronic liver diseases for a long time, with proven safety and efficacy in clinical settings. Previous studies suggest that the therapeutic mechanism of TCM for hepatitis B cirrhosis may involve the gut microbiota. Nevertheless, the causal relationship between the gut microbiota, which is closely linked to TCM, and cirrhosis remains unknown. This study aims to utilize two-sample Mendelian randomization (MR) to investigate the potential causal relationship between gut microbes and cirrhosis, as well as to elucidate the synergistic mechanisms between botanical drugs and microbiota in treating cirrhosis. Methods Eight databases were systematically searched through May 2022 to identify clinical studies on TCM for hepatitis B cirrhosis. We analyzed the frequency, properties, flavors, and meridians of Chinese medicinals based on TCM theories and utilized the Apriori algorithm to identify the core botanical drugs for cirrhosis treatment. Cross-database comparison elucidated gut microbes sharing therapeutic targets with these core botanical drugs. MR analysis assessed consistency between gut microbiota causally implicated in cirrhosis and microbiota sharing therapeutic targets with key botanicals. Results Our findings revealed differences between the Chinese medicinals used for compensated and decompensated cirrhosis, with distinct frequency, dosage, properties, flavors, and meridian based on TCM theory. Angelicae Sinensis Radix, Salviae Miltiorrhizae Radix Et Rhizoma, Poria, Paeoniae Radix Alba, Astragali Radix, Atrctylodis Macrocephalae Rhizoma were the main botanicals. Botanical drugs and gut microbiota target MAPK1, VEGFA, STAT3, AKT1, RELA, JUN, and ESR1 in the treatment of hepatitis B cirrhosis, and their combined use has shown promise for cirrhosis treatment. MR analysis demonstrated a positive correlation between increased ClostridialesvadinBB60 and Ruminococcustorques abundance and heightened cirrhosis risk. In contrast, Eubacteriumruminantium, Lachnospiraceae, Eubacteriumnodatum, RuminococcaceaeNK4A214, Veillonella, and RuminococcaceaeUCG002 associated with reduced cirrhosis risk. Notably, Lachnospiraceae shares key therapeutic targets with core botanicals, which can treat cirrhosis at a causal level. Conclusion We identified 6 core botanical drugs for managing compensated and decompensated hepatitis B cirrhosis, despite slight prescription differences. The core botanical drugs affected cirrhosis through multiple targets and pathways. The shared biological effects between botanicals and protective gut microbiota offer a potential explanation for the therapeutic benefits of these key herbal components in treating cirrhosis. Elucidating these mechanisms provides crucial insights to inform new drug development and optimize clinical therapy for hepatitis B cirrhosis.


Copper metabolism and hepatocellular carcinoma: current insights

July 2023

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154 Reads

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16 Citations

Copper is an essential trace element that acts as a cofactor in various enzyme active sites in the human body. It participates in numerous life activities, including lipid metabolism, energy metabolism, and neurotransmitter synthesis. The proposal of “Cuproptosis” has made copper metabolism-related pathways a research hotspot in the field of tumor therapy, which has attracted great attention. This review discusses the biological processes of copper uptake, transport, and storage in human cells. It highlights the mechanisms by which copper metabolism affects hepatocellular carcinogenesis and metastasis, including autophagy, apoptosis, vascular invasion, cuproptosis, and ferroptosis. Additionally, it summarizes the current clinical applications of copper metabolism-related drugs in antitumor therapy.


Crosstalk between 5-methylcytosine and N-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma

January 2023

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81 Reads

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71 Citations

Molecular Cancer

Background Accumulated evidence highlights the significance of the crosstalk between epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) and N⁶-methyladenosine (m⁶A). Herein, we conducted a widespread analysis regarding the crosstalk between 5mC and m⁶A regulators in hepatocellular carcinoma (HCC). Methods Pan-cancer genomic analysis of the crosstalk between 5mC and m⁶A regulators was presented at transcriptomic, genomic, epigenetic, and other multi-omics levels. Hub 5mC and m⁶A regulators were summarized to define an epigenetic and epitranscriptomic module eigengene (EME), which reflected both the pre- and post-transcriptional modifications. Results 5mC and m⁶A regulators interacted with one another at the multi-omic levels across pan-cancer, including HCC. The EME scoring system enabled to greatly optimize risk stratification and accurately predict HCC patients’ clinical outcomes and progression. Additionally, the EME accurately predicted the responses to mainstream therapies (TACE and sorafenib) and immunotherapy as well as hyper-progression. In vitro, 5mC and m⁶A regulators cooperatively weakened apoptosis and facilitated proliferation, DNA damage repair, G2/M arrest, migration, invasion and epithelial-to-mesenchymal transition (EMT) in HCC cells. The EME scoring system was remarkably linked to potential extrinsic and intrinsic immune escape mechanisms, and the high EME might contribute to a reduced copy number gain/loss frequency. Finally, we determined potential therapeutic compounds and druggable targets (TUBB1 and P2RY4) for HCC patients with high EME. Conclusions Our findings suggest that HCC may result from a unique synergistic combination of 5mC-epigenetic mechanism mixed with m⁶A-epitranscriptomic mechanism, and their crosstalk defines therapeutic response and pharmacogenomic landscape.



FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis

March 2022

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250 Reads

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31 Citations

Cancer Gene Therapy

Long non-coding RNAs (LncRNAs) have played very important roles in the malignancy behaviors of hepatocellular carcinoma (HCC). LncRNA LOC554202 (LOC554202) was a newly identified tumor-related lncRNA. However, its expression and function in HCC remained unknown. In this study, we firstly reported that LOC554202 expression was distinctly upregulated in HCC specimens and cell lines. Clinical assays indicated that increased LOC554202 expression had a diagnostic value for HCC patients and was positively associated with advanced stages and poor clinical prognosis. Additionally, forkhead box O3(FOXO3) could bind directly to the LOC554202 promoter region and activate its transcription. Functionally, we observed that knockdown of LOC554202 suppressed the proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) progress of HCC cells, and promoted apoptosis. Mechanistically, LOC554202 competitively bound to miR-485-5p and prevented the suppressive effects of miR-485-5p on its target gene basigin (BSG), which finally led to HCC metastasis, EMT, and docetaxel chemoresistance. Our data demonstrated that FOXO3-induced LOC554202 contributed to HCC progression by upregulating BSG via competitively binding to miR-485-5p, which suggested that the regulation of the FOXO3/LOC554202/miR-485-5p/BSG axis may have beneficial effects in the treatment of HCC.


Treatment and follow-up results of enteropathy-associated T cell lymphoma
Monomorphic Epitheliotropic Intestinal T Cell Lymphoma With Lower Gastrointestinal Hemorrhage: A Case Report and Literature Review

October 2021

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18 Reads

Enteropathy-associated T cell lymphoma(EATL) is a kind of malignant lymphoma with strong invasiveness. Due to poor effect of conventional symptomatic treatment, the prognosis is not as good as other T-cell lymphomas. A 63-year-old man was admitted to our hospital due to hematochezia. No definite cause was found by electronic gastroscopy and electronic colonoscopy. After symptomatic treatment, the patient's condition did not show significant remission. However, he refused further examination and was discharged. Two months later, the man was admitted to our hospital again due to hematochezia. The site of the lesion was found by capsule endoscopy and small intestinal endoscopy, and the nature of the lesion was confirmed by immunohistochemistry. The patient received chemotherapy and autologous stem cell transplantation after a definite diagnosis. No recurrence or metastasis has been found in an 18-months follow-up after treatment.


LINC00221 silencing prevents the progression of hepatocellular carcinoma through let-7a-5p-targeted inhibition of MMP11

April 2021

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31 Reads

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17 Citations

Cancer Cell International

Background Microarray profiles of hepatocellular carcinoma (HCC) identified that long intergenic noncoding RNA 00221 (LINC00221) was upregulated. Herein, we aimed to identify the functional significance and underlying mechanisms of LINC00221 in HCC. Methods and results Human HCC samples had increased expression of LINC00221. Effects of LINC00221 on HCC cellular functions were analyzed using gain- and loss-function approaches. LINC00221 knockdown repressed HCC cell growth, migration, and invasion and enhanced their apoptosis. This anti-tumor effect was validated in vivo. Online prediction showed the potential binding relationship between LINC00221 and let-7a-5p, as well as that between let-7a-5p and matrix metalloproteinase 11 (MMP11). The results of luciferase, RNA immunoprecipitation, and RNA pull-down assays identified that LINC00221 interacted with let-7a-5p to increase expression of MMP11. Furthermore, we demonstrated that LINC00221 silencing increased let-7a-5p and inhibited MMP11 expression, thereby delaying the progression of HCC in vitro. Conclusions Silencing of LINC00221 could prevent HCC progression via upregulating let-7a-5p and downregulating MMP11. As such, LINC00221 inhibition presents a promising antitumor strategy for the treatment of HCC.


In vivo and in vitro effects of microRNA-124 on human gastric cancer by targeting JAG1 through the Notch signaling pathway: miR-124 targeting JAG1 in GC via Notch pathway

January 2018

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287 Reads

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29 Citations

Journal of Cellular Biochemistry

In this study, we aim to determine the function of miR-124 on gastric cancer (GC) cells and the underlying mechanism that involves jaddeg1 (JAG1) and the Notch signaling pathway. GC tissues and adjacent tissues from 100 patients suffering from GC were selected. GC SGC-7901 and AGS cells were selected and grouped into control, mimic-NC, miR-124 mimic, inhibitor-NC, miR-124 inhibitor, and miR-124 inhibitor + si-JAG1 groups. RT-qPCR and a western blotting assay were conducted to detect the expression of miR-124, JAG1 and Notch signaling pathway-related proteins (NICD, HES1 and HES5). MTS, wound-healing, transwell assay and flow cytometry were performed to detect cell proliferation, migration, invasion, cell cycle distribution and apoptosis, respectively. Compared with adjacent tissues, a lower miR-124 expression and higher JAG1 expression were found in GC tissues. JAG1 is a direct target gene of miR-124. Compared with the control group, the expression of JAG1, NICD, HES1, and HES5, cell invasion, migration and proliferation in the miR-124 mimic group were decreased, while the apoptosis rate was increased and cells were arrested at the G0/G1 phase. Compared with the miR-124 inhibitor group, the expression of JAG1, NICD, HES1, and HES5, cell invasion, migration and proliferation in the miR-124 inhibitor + si-JAG1 group were decreased, while the apoptosis rate and cell ratio at the G0/G1 phase were increased. The demonstration that miR-124 inhibits GC cell growth supports the concept that miR-124 functions as a tumor suppressor by a mechanism that involves translational repression of the JAG1 and the inhibition of Notch signaling pathway. This article is protected by copyright. All rights reserved



Citations (7)


... environment, society, behavior, psychology, etc.) and diseases [18,19]. At present, there is a growing trend of utilizing MR studies to identify drug targets by elucidating the relationships between drug target genes and diseases, which may disclose potential therapeutic mechanisms and crucial targets for disease management [20][21][22][23]. In this research, a multidimensional data analysis strategy integrating conventional bioinformatics methods with MR studies was used to explore the therapeutic potential of Bi Qi capsules in the treatment of gout (Figure 1). ...

Reference:

Exploring Therapeutic Potential of Bi-Qi Capsules in Treatment of Gout by Discovering Crucial Drug Targets
Convergent application of traditional Chinese medicine and gut microbiota in ameliorate of cirrhosis: a data mining and Mendelian randomization study

... In watery conditions, such as bodily fluids, copper predominantly exists in the oxidised state of Cu 2+ . Conversely, upon traversing the cell membrane and entering the intracellular reducing milieu, copper is transformed into its reduced form, Cu + , which is essential for cellular absorption and utilization (Lelièvre et al., 2020;Guan et al., 2023;Zhou et al., 2023). Dietary copper predominantly exists as Cu 2+ , necessitating Intracellular copper regulates pathways. ...

Copper metabolism and hepatocellular carcinoma: current insights

... N6-methyladenosine methylation, the most prevalent internal mRNA modification in eukaryotic cells, plays a critical role in various physiological functions of the liver as well as in the pathogenesis of numerous liver diseases [26][27][28]. Recent studies have demonstrated that m6A can modulate IRI in the liver through multiple mechanisms. ...

Crosstalk between 5-methylcytosine and N-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma

Molecular Cancer

... To demonstrate the effectiveness of our method, based on our method, we selected 20 genes closely associated with the prognosis risk of liver hepatocellular carcinoma (HCC) from the genes identified by our model, which are presented in Table 4. Additionally, we conducted a literature review and found that 17 of these genes are related to liver cancer, while the remaining three are associated with other cancers: BET1L (cancer related [26]), CBR4 (cancer related [27]), AHCY (cancer related [28]), IGFBP5 (HCC related [29]), RPS7 (HCC related [30]), PRKAG2 (HCC related [31]), TNFRSF1A (HCC related [32]), HNRNPUL2 (HCC related [33]), APOH (HCC related [34]), MMP11 (HCC related [35]), ANTXR1 (HCC related [36]), CD69 (HCC related [37]), EEF1E1 (HCC related [38]), FOXP4 (HCC related [39]), MAP3K2 (HCC related [40]), CTSZ (HCC related [41]), CWF19L1 (HCC related [42]), DPH2 (HCC related [43]), GLUL (HCC related [44]), ISOC1 (HCC related [45]). Due to length constraints, we did not review the remaining prognostic genes. ...

LINC00221 silencing prevents the progression of hepatocellular carcinoma through let-7a-5p-targeted inhibition of MMP11

Cancer Cell International

... Likewise, miR-485-5p was significantly downregulated in human HCC tissues, and it was recently found to inhibit HCC progression by disrupting the WBP2/ Wnt signaling pathway [21][22][23]. Several studies suggested miR-485-5p as a common target of different lncRNAs that promote HCC progression via sponging miR-485-5p [24][25][26]. Circulating miR-485-5p has shown promise as a potential biomarker for some cancers [27,28]. Evidence about its clinical significance as a potential biomarker in HCC patients is lacking. ...

FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis

Cancer Gene Therapy

... Recently, an NMA focused on the efficacy of 17 regimens that do not differentiate the specific chemotherapies, especially capecitabine, 5-FU, leucovorin, irinotecan, and oxaliplatin, in each treatment comparison (6). Another study evaluated the efficacy of 10 regimens for first-line chemotherapy in patients with advanced CRC; however, their safety profiles have not been investigated (7). Therefore, by performing an NMA of randomized controlled trials (RCTs), we aimed to investigate the comparative efficacy and safety of several treatment regimens in patients with advanced or metastatic CRC. ...

Network meta-analysis of the efficacy of first-line chemotherapy regimens in patients with advanced colorectal cancer

Oncotarget

... Xiao's reported that when miR-124 overexpression in GC the expression of the JAG1 and EZH2 was downregulated, and silencing of JAG1 or EZH2 by RNA interference also suppressed GC cell growth and metastasis. It has been certified that the JAG1 mRNA overexpressions were found in low differentiation adenocarcinoma, samples with lymph node metastasis, and samples at stage II, II and IV in GC tissue 29 . In our data, we found that high JAG1 expression was associated with worsening OS for 10 years of follow-up in GC patients. ...

In vivo and in vitro effects of microRNA-124 on human gastric cancer by targeting JAG1 through the Notch signaling pathway: miR-124 targeting JAG1 in GC via Notch pathway
  • Citing Article
  • January 2018

Journal of Cellular Biochemistry