Lidia Maria Rebolho Batista Arantes's research while affiliated with Hospital de Câncer de Barretos and other places

... More recently, ectopic lymphoid aggregates, namely tertiary lymph structures (TLS), have been observed in many solid cancers including PDAC. Composed of organized B cells and T cells, TLS presence has been positively associated with immunotherapy efficacy and favorable survival of PDAC patients (103,104). Underlying mechanisms most likely attributed to TLS functioning as tumor immunity hub readily available in TME (103,104). In addition, it is postulated that the presence of sparse or organized B cells within tumors may play divergent roles in tumor immunity. ...

... In this issue 33.1 of the JHGD, as per its tradition since 1994, contributions are sequenced with research papers, reviews, case studies and innovative experiences aimed at promoting human growth and development, with an emphasis on children and adolescents [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] . ...

... Notably, the same brain region contains a vast range of neuronal types that are classified by morphological, anatomical, and physiological features. [26,27] The function underlying depressive function in mouse model [28][29][30] Response to antidepressants [20,[31][32][33][34] Anxiety-like behaviors [28,29] Cocaine reward-seeking behavior [17] Relations with nicotine addiction in human beings [35,36] Circadian rhythm [22] Sleep regulation and NREM sleep [37] VI Spatial memory reversal and Contextual memory extinction [38] Dendrites localization and Distal dendritic development [24] Relations with schizophrenia patients [21] Schizophrenia-like phenotypes in mice [11] To investigate the function of specific Bdnf promoters, our group (Dr. Bai Lu and colleagues) generated mouse lines, named Bdnf -e1 −/− , e2 −/− , e4 −/− , and e6 −/− mice, in which Bdnf Promoters I, II, IV, and VI were selectively disrupted. ...

... Regarding infectious diseases as a risk factor, a hospital-based study conducted in India reported that HPV prevalence was highest in the oropharynx (41.7%) followed by the hypopharynx (38.9%) and oral cavity (28.4%) [37]. Furthermore, it has been reported that Epstein-Barr virus (EBV) is associated with nasopharyngeal cancer [38]. Conversely, the associated risk factors of HNC in developed countries such as Australia were due to tobacco use especially smoked form as well as alcohol consumption [39]. ...

... However, there were no methylation differences between the buffy coats of individuals with and without MetS in the CpGs evaluated for the 1F region, even though the expression of these genes is similar in blood and hypothalamus. Although no association studies of MetS with NR3C1 differential methylation were found in the literature, variations in its methylation patterns have been observed for related comorbidities, such as cardiovascular diseases [22], subclinical arteriosclerosis (hypermethylation of the 1F promoter, in a study with monozygotic twins) [66], overweight (hypomethylation of the 1F region, CpGs 40 to 47) [51], unfavorable prognosis for coronary acute syndrome in individuals with depression (hypermethylation of exon 1F) [67], blood pressure (hypermethylation of 1F and 1H promoters associated with lower blood pressure) [68], and a positive association between methylation and glucose levels as well as insulin resistance [69]. Considering the multiple alternative first exons and their variability in tissue-specific expression, and that each of these exons has its own active promoter, DNA methylation and other epigenetic mechanisms should be evaluated in other regions. ...

... Diagnosing cancer and other diseases using data from non-specific sensors, like electronic tongues (e-tongues), poses challenges due to the lack of selectivity and the variability of biological samples [119]. Braz et al. [119] presented an e-tongue biosensor based on microfluidic impedance flow cytometry for mouth cancer detection. ...

... One-carbon metabolism and DNA methylation are events influenced by nutrients obtained through the diet [81,82]. DNA methylation is an epigenetic mechanism in which methyl groups from S-adenosyl-L-methionine (SAM) are added to cytosines in nucleotides altering the DNA accessibility and stability. ...

... Because of aberrant HDACs expression in many cancers, histone deacetylase inhibitors (HDACi) are becoming popular for cancer treatment. HDACi induce changes in chromatin structure, which has an impact on multiple genes and molecular pathways and affects gene transcription, DNA repair, and replication [86]. Therapeutic efficacy of HDACi has been demonstrated in many solid carcinomas [87]. ...

... While previous studies have examined the impact of polymorphisms within BMPs or their expression on colorectal cancer (CRC) [53][54][55][56][57], only the BMP3 gene has been previously identified as hypermethylated in CRC tissue [58,59]. In our comprehensive study of miRNA-target gene expressions in colorectal cancer, we have previously identified the overexpression of the BMP4 gene in colorectal cancer tissue [60]. ...

... [3] The status of surgical margin is an important prognostic factor with respect to treatment outcome. [4] However, even with histologically tumor-free margins, 10-30% of OSCC cases develop local recurrence (LR). [2,4] Hence, assessment of early molecular alterations in histologically tumor-free margins of OSCC before the inception of the cancer phenotype is essential to ...