April 2025
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3 Reads
Journal of Agricultural and Food Chemistry
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April 2025
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3 Reads
Journal of Agricultural and Food Chemistry
April 2025
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2 Reads
Journal of Biotechnology
April 2025
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5 Reads
Food Research International
April 2025
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1 Read
Food Hydrocolloids
March 2025
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30 Reads
Background: Acute pancreatitis (AP) leads to severe inflammation and nutritional deficits, with 80% of severe cases experiencing critical protein loss. Timely enteral nutrition is essential for recovery. This study systematically reviews and analyzes the incidence and predictors of enteral nutrition intolerance (ENI) in AP patients. Methods: Web of Science, Embase, Cochrane Library, and PubMed were searched up to May 2024. Studies reporting on ENI incidence and predictors in AP patients were included based on predefined criteria. Bias was assessed using standardized tools, and meta-analyses provided summary estimates with confidence intervals. Results: From the 2697 screened studies, 28 involving 4853 patients met the inclusion criteria. The pooled incidence of ENI was 26%. Significant predictors included comorbid diabetes, pancreatic necrosis, elevated pre-refeeding serum lipase levels, peri-pancreatic fluid collections, and systemic inflammatory response syndrome at admission. Higher ENI rates were observed in Europe, among patients with severe acute pancreatitis (SAP), those receiving nasoenteric feeding, and in prospective study cohorts. Conclusions: ENI affects approximately one-quarter of AP patients and is not significantly associated with age, sex, or the cause of AP. Its incidence varies by region, disease severity, feeding method and study design. Identifying predictors, such as comorbid diabetes and pancreatic necrosis, may help clinicians reduce the risk of ENI. The limitations of this study include the heterogeneity of the included studies and inconsistent ENI diagnostic criteria.
March 2025
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5 Reads
BACKGROUND Exopolysaccharide (EPS) produced by Streptococcus thermophilus can significantly improve the viscosity, texture and taste of dairy products, which have broad application potential in the food industry. However, EPS production is typically low (< 100 mg L⁻¹) in S. thermophilus, making it difficult to meet industrialization requirements. The utilization of metabolic engineering for genetic modification of S. thermophilus is an efficient approach to enhance EPS biosynthesis. RESULTS To our knowledge, there is lack of systematic investigation on engineering UDP‐sugar synthetic pathways for EPS production in S. thermophilus. In the present study, the biosynthetic genes of EPS precursors UDP‐glucose and UDP‐galactose were regulated for improving EPS production in S. thermophilus AR333. Compared with the control, engineered strains by single overexpression of eight EPS precursor genes increased EPS production by 7–31%, respectively. Among of them, overexpressing glk encoding glucokinase and galE1 encoding UDP‐galactose‐4‐epimase led to 275.37 and 288.65 mg L⁻¹ of EPS production, respectively. Moreover, co‐overexpression of lacZ encoding β‐galactosidase and galE1 achieved a remarkable 49% increase in the EPS production (329.51 mg L⁻¹). Transcriptional analysis further suggested that enhanced EPS synthesis in engineered strain can attributed to the upregulation of precursor genes and clusters of EPS genes. CONCLUSION Our results showed that engineered UDP‐sugar synthesis is an efficient strategy to boost EPS production in S. thermophilus. © 2025 Society of Chemical Industry.
March 2025
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10 Reads
International Journal of Biological Macromolecules
March 2025
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1 Read
Food Chemistry X
February 2025
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10 Reads
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1 Citation
npj Science of Food
The Western diet (WD) leads to hepatic lipid metabolism disorders. Previous studies have shown that the bile salt hydrolase 1 (bsh1) gene of Lactobacillus plantarum AR113 attenuates colitis under WD. In this study, we preliminarily explored how AR113 attenuates the hepatic inflammatory response in colitis mice on the WD. Our study suggests that the WD leads to abnormalities in hepatic lipid metabolism and dysbiosis of the gut microflora, and furthermore, there may be a correlation between abnormalities in lipid metabolism and hepatic inflammatory responses. AR113 significantly regulated lipid and bile acid metabolism in the liver of mice treated by WD and Dextran sulfate sodium (DSS), affected the structure of the mouse intestinal flora, and inhibited the expression of Sterol regulatory element-binding protein 1C (SREBP-1C) and P-NF-κB p65 at the protein level, thereby attenuating the hepatic injury phenotype. However, the bsh1 knockout strain did not exhibit the above function.
February 2025
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7 Reads
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1 Citation
International Journal of Biological Macromolecules
... Notably, the relative abundance of Ruminiclostridium_6 demonstrated a positive correlation with lymphosin-α and IL-17, and a negative correlation with BW change, suggesting its potential as an indicator of colitis progression [36]. Our results also identified a strong positive correlation between Escherichia_Shigella and pro-inflammatory cytokines IL-17 and IFN-γ, which aligns with previous studies highlighting the pathogenic nature of Escherichia_Shigella in colitic mice [37]. The reduction in the relative abundance of Escherichia_Shigella and downregulation of pro-inflammatory cytokines following L. plantarum treatment underscores its therapeutic potential, which is consistent with other studies demonstrating the beneficial effects of L. plantarum in decreasing gut pathogenic bacteria and mitigating inflammatory responses [38,39]. ...
February 2025
npj Science of Food
... Specific bacterial genera have been identified to influence bone cell activities, particularly osteoclastogenesis (the formation of osteoclasts) and osteoblast activity (bone-forming cells) [8,[54][55][56]. For instance, Lactobacillus strains have been shown to inhibit osteoclast differentiation by reducing pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α) and interleukin (IL)-1β, which are critical for osteoclast formation [57,58]. Additionally, Limosilactobacillus reuteri ( L. reuteri) maintains the Wnt signaling pathway, essential for osteoblast proliferation and differentiation, thereby promoting bone formation [59,60]. ...
September 2024
... Many recent studies have confirmed the ability of lactic acid bacteria, especially the genera Bifidobacterium and Lactobacillus, to break down oxalates to format and CO 2 [5,6]. Qin et al. [7] reported isolating four [8] indicated that Lb. acidophilus bacteria degraded oxalates in industrially prepared gastric fluid by 48%. The present investigation aimed to identify species of lactic acid bacteria from human sources and fermented foods and study their ability to degrade oxalates in vetro ...
September 2024
Food & Function
... Common findings include mucosal erythema and ulcerations limited to the rectum and sigmoid colon. Histopathological examination confirms ulcerative colitis through crypt abscesses and mucosal inflammation [29][30][31] . Chronic cases often show basal plasmacytosis and fibrosis. ...
September 2024
npj Biofilms and Microbiomes
... Probiotics may improve the health of the microbiota in the gut, make insulin work better, and reduce inflammation. All of these effects may lead to better metabolic outcomes in people with T2DM [20,21]. ...
August 2024
... Utilizing biomass to harness its inherent charactertics, biosorption has been emerged as an e cient and sustainable biological method for remedying heavy metals (HMs) contamination in wastewater 24,25 . ...
August 2024
Biosensors and Bioelectronics
... Smart sensors and Internet of Things devices are driving this paradigm shift, enabling real-time tracking and data collection throughout the food production and distribution process. Conventional detection methods, such as atomic absorption spectroscopy (AAS), high-performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS), are hindered by extensive sample preparation, high costs, and lengthy detection times, limiting their broad applications (Abid et al. 2024;Gao et al. 2024;G. Jiang et al. 2024). ...
July 2024
Food Research International
... Low albumin levels may increase the risk of infection and systemic inflammation, potentially leading to organ dysfunction in patients with decompensated cirrhosis. Additionally, hypoalbuminemia can impair vascular endothelial cell function and increase capillary permeability, further contributing to the risk of UGIB [39]. Additionally, elevated total bilirubin (TBIL) exacerbates hepatic dysfunction, aggravates portal hypertension, and impairs coagulation, all of which contribute to UGIB and increase the risk of variceal rupture and mucosal injury [40]. ...
June 2024
... Figure 4 determine their technological applications. For example, xyloglucan obtained by soaking seeds as a decorticate method can be used in pharmaceutical products with low viscosity (ophthalmological and nasal formulations) [8,69], as well as a thickening agent in juices and nectars [70]. On the other hand, xyloglucan from roasted seeds is adequate in film and coating development and as an excipient in gel formulation [71,72]. ...
May 2024
Food Hydrocolloids
... In addition, the suppression of α-glucosidase activities by polyphenols is primarily due to the establishment of hydrogen bonds and hydrophobic interactions between these enzymes and the polyphenolic compounds [23]. The number of hydrogen bonds is pivotal in inhibiting the catalytic ability of the enzyme [46]. As shown in Figure 4, at the active site of α-glucosidase, 3,4-diCQA formed seven hydrogen bonds with amino acid residues Ser241, Asp242, Gln279, His280, Asp307, and Asp352 (Figure 4(A4)); 3,5-diCQA, rutin, and 4,5-diCQA formed three hydrogen bonds with amino acid residues (Figure 4(B4-D4)); and 3-CQA formed nine hydrogen bonds with amino acid residues Asn259, Thr274, Thr290, His295, Glu296, Ser298, and Asp341 (Figure 4(E4)). ...
May 2024
Food & Function