Leonardo Bertagna De Marchi's research while affiliated with University of Padova and other places

Publications (4)

Article
Full-text available
Background: A higher risk for COVID-19 infection and severity for men compared to women has been described since the beginning of the pandemic. The role of androgens has been recently highlighted as they control two key steps of coronavirus infection mediated through the transmembrane protease serin 2 (TMPRRS2) and the angiotensin-converting enzyme...
Article
Pulmonary fibrosis (PF), a pathological outcome of chronic and acute interstitial lung diseases associated to compromised wound healing, is a key component of the “post-acute COVID-19 syndrome” that may severely complicate patients’ clinical course. Although inconclusive, available data suggest that more than a third of hospitalized COVID-19 patien...
Article
Full-text available
Background: Patients with COVID-19 may experience hypoxemic Acute Respiratory Failure (hARF) requiring O2-therapy by High-Flow Nasal Cannula (HFNO). Although Prone Positioning (PP) may improve oxygenation in COVID-19 non-intubated patients, the results on its clinical efficacy are controversial. The present study aims to prospectively investigate...

Citations

... Community-acquired pneumonia (CAP) is considered a sort of pneumonia [1] developed outside hospitals, and clinics, along with infirmaries [2]. CAP may affect people of any age, but it is more prevalent in very young and elderly groups, which may need hospital treatment if they develop CAP [3]. ...
... Han et al. identified age >50 years and heart rate >100 beats per minute at admission as independent predictors of fibroticlike changes in survivors of severe COVID-19 pneumonia at a 6-month follow-up (61). Finally, cytokines such as interleukin-6 and upregulation of other growth factors such as TGF-β1, FGF, and EGF also contribute to the development of pulmonary fibrosis (89,90). Neutrophil extracellular traps play a key role in the interplay between inflammation and thrombotic changes in the lung. ...