Leonard J. Newman’s research while affiliated with New York Medical College and other places

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Publications (73)


Fructose Intolerance in Children Presenting With Abdominal Pain
  • Article

October 2008

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60 Reads

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86 Citations

Journal of Pediatric Gastroenterology and Nutrition

Robert E Gomara

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Michael S Halata

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Leonard J Newman

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[...]

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We determined the occurrence of fructose malabsorption in pediatric patients with previous diagnoses of abdominal pain caused by a functional bowel disorder, whether the restriction of fructose intake changes the reporting of symptoms, the role of fructose dosage, and the severity of resultant symptoms. We administered a fructose breath test to children presenting with persistent unexplained abdominal pain. Patients randomly received 1, 15, or 45 g fructose, and breath hydrogen was measured for 3 hours after ingestion. Test results were positive when breath hydrogen was 20 ppm greater than baseline and was accompanied by gastrointestinal symptoms. A total of 32 patients was enrolled, and none of the 9 who received 1 g had positive results. Three of 10 who received 15 g and 8 of 13 who received 45 g had positive results. All patients with positive test results restricted their fructose intake. Among the group with positive results, 9 of 11 had rapid improvement of their gastrointestinal symptoms. After 2 months, all 9 patients continued to report improvement. We concluded that fructose malabsorption may be a significant problem in children and that management of dietary intake can be effective in reducing gastrointestinal symptoms.








FIG. 1. Relation between percentage of positive fructose breath test results and amount of fructose ingested, tested nonparametrically, showing significantly positive association (P < 0.005). 
TABLE 1 . Results of fructose breath test
FIG. 2. Representative tracing of breath hydrogen excretion measured after ingestion of 45 g fructose. 
FIG. 3. Distribution of symptoms reported by all patients tested after ingestion of either 45, 15, or 1 g fructose. 
FIG. 4. Resolution of gastrointestinal symptoms associated with fructose restriction for 2 months. Symptom intensity was recorded on a scale of 0 to 3 before the fructose breath test and compared with responses obtained after restriction of fructose ingestion for 2 months. Ã Significance (P < 0.05). 
FRUCTOSE INTOLERANCE IN CHILDREN PRESENTING WITH ABDOMINAL PAIN: 89*
  • Article
  • Full-text available

October 2005

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826 Reads

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20 Citations

Journal of Pediatric Gastroenterology and Nutrition

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Citations (36)


... 9-13 A continuous 24-hour pH probe is relatively safe and provides a reproducible method for measuring acid reflux in infants. [14][15][16][17][18] The aim of this study was to compare the effects of a traditional whey-based infant formula thickened with 5% rice cereal to a casein-predominant infant formula pre-thickened with pre-gelatinized cornstarch on clinical symptoms in children with GER and evaluation of esophageal pH over 24-hours. ...

Reference:

Nutritional Management of Children with Gastroesophageal Reflux: A Comparison of Two Different Formulas
A New Ambulatory System for Extended Esophageal pH Monitoring
  • Citing Article
  • October 1985

Journal of Pediatric Gastroenterology and Nutrition

... La fructosa, como lactosa, cuando es mal absorbida por los pequeño lumen intestinales, puede causar una diarrea osmótica y también sirven como un sustrato para la fermentación bacteriana del colon, y por lo tanto, la producción de gas y posterior dolor abdominal. (Gomara, Halata, & Newman, 2008) encontraron 11 de 32 niños con TGFs por fructosa mal absorbida. Síntomas gastrointestinales tales como náuseas, hinchazón, y dolor abdominal también fueron más frecuentes en el grupo de dosis más alta fructosa (P <0,05). ...

FRUCTOSE INTOLERANCE IN CHILDREN PRESENTING WITH ABDOMINAL PAIN: 89*

Journal of Pediatric Gastroenterology and Nutrition

... Several medications may cause mucosal inflammation and ulceration. Although NSAID are generally safe and are often used to control fever, even the use of a single dose in children may cause GI bleeding [12]. In a previous study, ulcerogenic medication use was found in 16.5% of peptic ulcer patients [2]. ...

Gastrointestinal bleeding following ingestion of low-dose ibuprofen
  • Citing Conference Paper
  • September 2005

The American Journal of Gastroenterology

... [1,2] Seventy percent of neonatal NBLs fall into the low-risk group. [5] In cases where treatment is indicated, they are associated with good clinical outcomes. [2][3][4] The INRGSS recommends surgery alone for low-risk accessible tumours, biopsy with adjuvant chemotherapy, and surgery for intermediate risk disease and intensive adjuvant chemotherapy, and surgery for high-risk disease. ...

678 THE VALUES OF ABDOMINAL GIRTH MEASUREMENT
  • Citing Article
  • April 1985

Pediatric Research

... Crucially, we also found that patients who were positive for fructose malabsorption or fructan malabsorption had 1.951 times higher odds of testing positive for the other carbohydrate. Previous work showed that fructose-and fructan-free diets improved symptoms in patients with IBS and fructose malabsorption [36][37][38][39]. Our results support their findings, as almost a quarter (22.6%) of tested patients were positive for both fructose and fructan malabsorption. ...

Fructose Intolerance in Children Presenting With Abdominal Pain
  • Citing Article
  • October 2008

Journal of Pediatric Gastroenterology and Nutrition

... Colonic intramural hematoma is an uncommon complication of diagnostic colonoscopy, with only a handful of reported cases (2)(3)(4). Colonic hematomas have been reported in children secondary to accidental and nonaccidental trauma, bleeding disorders, and anticoagulant therapy (5)(6)(7)(8). This is one of the first reported case of colonic hematoma complicating diagnostic colonoscopy in a pediatric patient. ...

Colonie Hematoma After Blunt Abdominal Trauma
  • Citing Article
  • August 1992

Journal of Pediatric Gastroenterology and Nutrition

... 6 However, some studies found that even in the absence of the characteristic symptoms of GER such as heartburn, regurgitation, pain on swallowing, dysphagia, hemorrhage, or 'water brash', chil- dren with chest pain could be diagnosed as GERD. 4,9 Dekel et al. also indicated that the symptom index provided very little improvement in diagnosing GERD-related noncardiac chest pain in adults. 10 Similarly in our study, except for the respiratory associated symptoms for proximal sensor (Table 4), GERD symptom positivity (frequency of characteristic symptoms of GERD) was not significantly different between GERD-positive and GERD-negative groups for both sensors. ...

Spectrum of esophageal disorders in children with chest pain
  • Citing Article
  • June 1992

Digestive Diseases and Sciences

... En este estudio los principales síntomas asociados fueron vómito (38%), dolor abdominal (23%) y hematemesis (23%), lo cual es similar a lo encontrado en otras publicaciones 6,7,11 . También se relaciona con disfagia 5,9 , pobre crecimiento 7,11 y dolor epigástrico 10,11 . ...

Endoscopic Removal of Inflammatory Esophagogastric Polyps in Children
  • Citing Article
  • August 1991

Journal of Pediatric Gastroenterology and Nutrition

... Las complicaciones más frecuentes en nuestra serie fueron las respiratorias en el 26% de los casos, semejante a la tasa observada por otros autores (2,3,6,8,12), que serían consecuencia del abuso de alcohol y tabaco que deterioran la fu nción pulmonar prcoperatoria, Ja disección traqueal extensa, la prolongada duraci ón de la intervención y la posibilidad de una parálisis recurrencial que altera los mecanismos de cierre de la glotis al toser (2,13). En cuanto al tipo de intervención quirúrgica, Fok y cols. ...

Coombs-Positive Hemolytic Anemia Preceding Ulcerative Proctitis
  • Citing Article
  • September 1991

Journal of Pediatric Gastroenterology and Nutrition

... In a study, it was shown that the increase in the frequency of reflux in MVP patients is associated with chest pain. [15] Coronary anomalies are perhaps the most important pathology among structural cardiac anomalies. It is often difficult to diagnose. ...

Noncardiac chest pain in adolescents and children with mitral valve prolapse
  • Citing Article
  • June 1991

Journal of Adolescent Health