Leo Kang Yang Lim's research while affiliated with Tan Tock Seng Hospital and other places
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Publications (9)
Objective
To describe the molecular epidemiology of Mycobacterium tuberculosis complex (MTBC) and factors associated with its transmission in Singapore.
Methods
Spoligotyping, 24-loci mycobacterial interspersed repetitive units – variable number of tandem repeats (MIRU-VNTR) typing and demographic data from the national TB notification registry of...
Background
Previously treated ie. recurrent tuberculosis (TB) cases account for ~7-8% of incident TB globally and in Singapore. Molecular fingerprinting has enabled the differentiation of these patients into relapsed or re-infection cases.
Methods
Patient demographics, disease characteristics and treatment information were obtained from the nation...
There were 290 multidrug-resistant (MDR)-TB cases diagnosed in Singapore from 2006 to 2018. Eighty-one percent were foreign-born. Spoligotyping and MIRU-VNTR methods identified 108 patients in 24 clusters. The Beijing spoligotype accounted for 22 clusters. Whole genome sequencing (WGS) analysis reduced the number of clustered patients and clusters...
Singapore is an intermediate tuberculosis (TB) incidence country, with a recent rise in TB incidence from 2008, after a fall in incidence since 1998. This study identified population characteristics that were associated with the recent increase in TB cases, and built a predictive model of TB risk in Singapore.
Retrospective time series analysis was...
Singapore, which had a tuberculosis (TB) incidence rate of 41 per 100 000 resident population in 2011.
To report the outcomes of Singapore citizens and permanent residents treated for TB from 2002 to 2011.
A computerised treatment surveillance module (TSM) was launched in 2001 to track the progress and outcome of TB patients nationally. Physicians...
Surveillance for latent tuberculosis in high-risk groups such as healthcare workers is limited by the nonspecificity of the tuberculin skin test (TST) in BCG-vaccinated individuals. The Mycobacterium tuberculosis antigen-specific interferon-gamma release assays (IGRAs) show promise for more accurate latent tuberculosis detection in such groups.
To...
Citations
... As immunity decreases with age and people with suppressed immunity are prone to infectious diseases and in a TB high burden setting chances of recurrence increase. A retrospective case-control study conducted in Singapore reported age ≥60 years to be related to TB recurrence [64] while a study from Pakistan reported a high recurrence rate in the younger age group (15-45 years) [25]. Te diference between these reports likely refects the diference in the etiology of recurrence. ...
... Spatial and temporal distribution analysis has always been a prominent epidemiological tool to investigate infectious and vector-borne diseases (5)(6)(7)(8)(9), chronic diseases and injury (10)(11)(12)(13)(14)(15). Temporal distribution and its correlation with environmental and other human risk factors helps detect causality and risk (5,12,16,9). ...
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... We believe that this is testimony to A c c e p t e d M a n u s c r i p t the effectiveness of the Singapore TB Elimination Programme (STEP) which has, since 1998, utilized in-person DOT (daily during the intensive phase and thrice weekly in the continuation phase) at the patients" nearest public health care clinic for the majority of the country"s TB cases (18,19). The STEP"s Treatment Surveillance Module which actively tracks all TB cases in Singapore until their final outcome, has also served to ensure high treatment completion rates nationally (20). ...
Reference: Recurrent Tuberculosis Disease in Singapore
... In view of universal bacille Calmette-Guérin (BCG) vaccination at birth since the 1950s and a BCG re-vaccination programme for school leavers from the 1950s to 2001, it is likely that a tuberculin skin test (TST) survey would overestimate the reservoir of LTBI in the local population (Chee et al., 2009;Menzies and Vissandjee, 1992). This large population-based survey of LTBI in Singapore was performed by utilizing an interferon-gamma release assay (IGRA), the QuantiFERON Gold In-tube assay (QFT-GIT; Qiagen, Hilden, Germany), and represents the first such study. ...
