Lei Tu's research while affiliated with Huazhong University of Science and Technology and other places

Publications (33)

Article
Objectives Inflammatory bowel disease (IBD) usually present with systemic and gastrointestinal problems. This may result in both physical and psychological burden. The aim of the study was to investigate the association between psychological burden and Health Related Quality of Life (HRQoL), sleep quality and disease characteristics. Methods A tot...
Article
Full-text available
At present, it has been noticed that some patients recovered from COVID-19 present a recurrent positive RNA test of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) after being discharged from hospitals. The purpose of the current study was to characterize the clinical features of re-hospitalized patients with recurrent SARS-CoV-2 posit...
Article
The coronavirus disease 2019 (COVID-19) triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) erupted in Hubei Province of China in December 2019 and has become a pandemic. Severe COVID-19 patients who suffer from acute respiratory distress syndrome (ARDS) and multi-organ dysfunction have high mortality. Several studies have sho...
Preprint
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Background Patients with COVID-19 can develop myocardial injury and arrhythmia during the course of their illness. However, the underlying risk factors for the development of cardiovascular related manifestations are unclear. Methods Using a register-based multi-center cross-sectional design, we analyzed 80 patients with myocardial injury and 401...
Article
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Objectives: The COVID-19 epidemic triggered by coronavirus SARS-CoV-2 is rapidly spreading around the globe. This study is aimed at finding out the suspected or confirmed SARS-CoV-2 infection in patients with inflammatory bowel disease (IBD) in Hubei province, China. We also investigated symptoms, medications, life quality, and psychological issue...
Article
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Background: Clinical data suggest that enteral nutrition (EN) effectively decreases disease activity and maintains remission in patients with inflammatory bowel disease (IBD). However, the modulatory effects of EN on the intestinal mucosal immune system remain unclear. Aims: This study first aimed at comparing the therapeutic effects of three EN...
Article
Full-text available
The COVID-19 pandemic is a significant global event in the history of infectious diseases. The SARS-CoV-2 appears to have originated from bats but is now easily transmissible among humans, primarily through droplet or direct contact. Clinical features of COVID-19 include high fever, cough, and fatigue which may progress to ARDS. Respiratory failure...
Article
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Objective: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported in patients infected with the virus. In this study, we aimed to further investigate the prevalence and outcomes of COVID-19 patients with digestive symptoms. Methods: In this descriptive, cross-sectional...
Article
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Background: The global death toll from COVID-19 virus exceeds 21000. The risk factors for death were attributed to advanced age and co-morbidities, but haven't been accurately defined. Objectives: To report the clinical features of 85 fatal cases with COVID-19 in two hospitals in Wuhan. Method: Medical records of 85 fatal cases of COVID-19 bet...
Article
With over 1,800,000 cases and 110,000 deaths globally, COVID-19 is one of worst infectious disease outbreaks in history. The objective of this paper is to critically review the available evidence regarding the lessons learned from the Chinese experience regarding COVID-19 prevention and management. The steps that have led to a near disappearance of...
Article
Interleukin-33 (IL-33) has emerged as a critical regulator in a variety of diseases, including inflammatory bowel disease (IBD). IL-33 can be produced by various tissues and cells, and typically induces Th2-type immune responses via binding to the receptor ST2. In addition, accumulated data have shown that IL-33 also plays a modulatory role in the...
Article
There has been no report investigating the role of IL-38 in inflammatory bowel diseases (IBD). Therefore, we investigated the expression of IL-38 in IBD patients and its role in regulating intestinal inflammation. The levels of IL-38 were significantly elevated in the intestine of IBD patients and DSS-induced colitis mice. Immunofluorescence analys...
Article
Background The results of the esophageal body motility differences between liquid and solid swallows from high‐resolution manometry (HRM) studies are not consistent. The information of the frequency of ineffective liquid and solid bolus swallows in healthy individuals during HRM procedure is limited. The normative values of the HRM parameters of bo...
Article
Full-text available
As a cytokine in interleukin-1(IL-1) family, interleukin-33(IL-33) usually exists in the cytoplasm and cell nucleus. When the cells are activated or damaged, IL-33 can be secreted into extracellular and regulate the functions of various immune cells through binding to its specific receptor suppression of tumorigenicity 2 (ST2). Except regulating th...
Article
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Faecal calprotectin and faecal occult blood test (FOBT) were widely used in the diagnosis and assessment of intestinal inflammation in inflammatory bowel disease (IBD). Recently we identified an excellent new biomarker B cell-activating factor (BAFF) for IBD. Here in this study we compared the efficacy of faecal BAFF, calprotectin and FOBT to find...
Article
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Accumulated data have shown that alternatively activated macrophage exerts a modulatory role in many diseases, including colitis. Interleukin-33 (IL-33), a critical modulator in adaptive and innate immune, has been implicated in autoimmunity and inflammation. Previously, we have reported that IL-33 functions as a protective modulator in TNBS-induce...
Article
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CD103+ dendritic cells (DCs) have been shown to play a crucial role in the pathogenesis of inflammatory bowel diseases (IBDs) through educating regulatory T (Treg) cells differentiation. However, the mechanism of CD103+ DCs subsets differentiation remains elusive. Interleukin (IL)-4 is a pleiotropic cytokine that is upregulated in certain types of...
Article
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Objective . To study the pathogenic feature of liver injury, activation of hepatic stellate cells, and dynamic expression of TGF- β 1/TGF- β 3 to reveal their role in liver injury induced by ConA. Methods . Mice were randomly divided into control group and ConA treatment group. ConA (20 mg/kg) was injected through vena caudalis in ConA treatment gr...
Article
Aim: To investigate the effects of depression and anxiety on health-related quality of life (QoL) in gastroesophageal reflux disease (GERD) patients and those suffering from cardiac (CCP) and noncardiac (NCCP) chest pain in Wuhan, China. Methods: In this cross-sectional study, a total of 358 consecutive patients with GERD were enrolled in Wuhan,...
Article
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Aberrant T cell immune responses appear central to the development of systemic lupus erythematosus (SLE). We previously reported that Gαq, the alpha subunit of Gq, regulates T and B cell immune responses, promoting autoimmunity. To address whether Gαq contributes to the pathogenesis of SLE, Gαq mRNA expression was studied using real time-PCR in PBM...
Article
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Increased psychiatric comorbidity, predominantly anxiety and depressive symptoms, and lower quality of life (QoL) are associated with noncardiac chest pain (NCCP). We aimed to investigate the roles of anxiety and depression in the impaired QoL of NCCP patients in Central China. In this hospital-based cross-sectional study, 200 consecutive patients...
Article
Background: It is gradually accepted that solid bolus swallow needs to be added to the procedure of manometry. The motility differences in the upper esophageal sphincter (UES) and lower esophageal sphincter (LES) were not well described. Sierra Scientific Instruments solid-state high-resolution manometry (HRM) system, the most popular HRM system i...
Article
To investigate the influence of posture on the anatomy and function of esophageal sphincters using solid-state high-resolution manometry. Fifty subjects (24 volunteers and 26 gastroesophageal reflux disease patients) were recruited for this study. The subjects underwent esophageal manometry with a 36-channel solid-state catheter in the supine and u...
Article
Background The aims of this study were to investigate the effect of gastric electrical stimulation (GES) with different parameters on emesis induced by apomorphine, and possible center mechanisms by brain functional magnetic resonance imaging (fMRI).Methods Six dogs implanted with electrodes on gastric serosa were used in this study. Part 1: Apomor...
Article
Full-text available
Most recent studies using high-resolution manometry were based on supine liquid swallows. This study was to evaluate the differences in esophageal motility for liquid and solid swallows in the upright and supine positions, and to determine the percentages of motility abnormalities in different states. Twenty-four asymptomatic volunteers and 26 pati...
Article
The physical performance characteristics and manometry principle are completely different between solid-state high-resolution manometry (SHRM) and water-perfused high-resolution manometry (WHRM). The consistency between SHRM and WHRM in esophageal manom etry has not yet been known. To investigate the consistency between SHRM and WHRM in testing eso...
Article
Past studies have shown that catheter diameter is one of the device-dependent problems which influence the manometric results in the conventional water perfusion esophageal manometry. High-resolution solid-state manometry which abandons water perfusion is thought as an improved manometry method benefited from more pressure sensors, and it is gradua...
Article
The aims of this study were to investigate the effects of cisplatin (DDP) on gastric myoelectrical activity and the roles of gastric electrical stimulation (GES) in the treatment of drug-induced emesis in dogs. Four pairs of electrodes were implanted in gastric serosa in seven female dogs, all dogs performed followed two-session study: intravenous...

Citations

... Extreme tissue necrosis occurs as a result of increased cytokine production. In certain scenarios, a reaction known as a "cytokine storm" occurs (19). This is administered in combination with its potential treatments. ...
Reference: Issue: 11
... Only two studies performed genome sequencing from naso-/oropharyngeal samples, but full-length viral genomes could not be obtained [12,72]. Eight studies reported testing or follow-up of contacts, but no onward transmission was identified [70,[72][73][74][75][76][77][78]. The quality of observational studies was assessed on a scale of zero to 14. Included publications were rated between 3 [79] and 11 [65,78,80], as shown in S5 Table. ...
... The results of a study evaluating the impact of epidemiological measures on social distancing and isolation at home showed that symptoms of anxiety and depression, as well as QoL impairment, were found in 20-30% of patients [15]. Other studies that quantified the effects of COVID-19 epidemiological measures on the health of patients with chronic conditions showed that QoL was unaffected by COVID-19 [16,17]. Based on these premises, the present study aims to assess the impact of the COVID-19 pandemic on the QoL of patients with IBD. ...
... Sulfur-containing amino acids such as methionine, taurine, homocysteine, and cysteine are abundant in plants and animals with numerous biological activities [174]. They exhibit significant antioxidant and anti-inflammatory effects [174,175]. Sulfurcontaining amino acids are metabolically interconnected, therefore a clear discrimination of their actual contribution to a biological effect cannot always be achieved. For instance, homocysteine is a product of the methionine cycle. ...
... To date, reliance on the diagnosis of cardiac injury has been based mainly on serum cardiac biomarkers that cannot differentiate between different types of cardiac injury, and which may be raised in conditions such as septic shock and in secondary bacterial infection without the presence of cardiac injury; furthermore, it has also been proposed that demonstration of the true attributable mortality due to cardiac injury in COVID-19 infection is lacking. [22,23] Clearly, we need more investigation of the types, mechanisms and treatment of these cardiac events, in order to understand and manage them better. [22,23] Additional thromboembolic events that have been described, over and above the cardiac events of acute coronary syndrome/acute myocardial infarction, include both arterial and venous events, most commonly acute pulmonary embolism, [9,10,13] as well as deep venous thrombosis, upper limb venous thrombosis, peripheral arterial thrombosis, stroke and various others. ...
... Viral infection is an important factor predisposing for cancer, and related reports have shown that coronaviruses are associated with certain tumors. It has been confirmed that the virus exists in the intestines of patients with COVID-19 [17,[26][27][28], and approximately 15% of patients with COVID-19 have gastrointestinal symptoms along with respiratory symptoms [29]. However, the relationship between coronavirus and CRC is not yet known. ...
... All things being equal, the susceptible population for the COVID-19 pandemic is concentrated in the elderly and the sub-healthy, and this population is characterised by a weaker physical condition. According to research, people who are in better health have a lower rate of infection and a faster recovery rate from the disease [54,55]. The example of the Newcastle pneumonia outbreak shows the role of good health in the early stages of a public health emergency as an outpost for disease prevention and highlights the important role of good health and a healthy lifestyle in reducing the prevalence of more diseases. ...
... Walby [35] and others [3] revealed that the state reproduced patriarchy through public policies while providing women spaces to negotiate with it. Wang [36] found that socialist feminists unsuccessfully resisted patriarchy on multiple fronts when they sought to implement egalitarian visions of a modern socialist China within the Communist Party and state bureaucracy. ...
... Similarly, Ramachandran et al. reported that the patients using PPIs did not have higher GI symptoms compared to controls (Ramachandran et al., 2022). Furthermore, some studies reported digestive symptoms such as dysgeusia and anosmia (Aziz et al., 2020;Bénézit et al., 2020), nausea, loss of appetite, and diarrhea are common in COVID-19 patients (Aziz et al., 2020;Pan et al., 2020;Perisetti et al., 2020). Luxenburger et al. indicated that treatment with PPI before hospitalization may be a factor for development of acute respiratory distress syndrome (ARDS) and secondary infection (Luxenburger et al., 2021). ...
... Several studies found high levels of proinflammatory cytokines, such as IL-6, TNFα, and IFNγ, as well as T cell lymphopenia, decrease of non-classical (CD14 lo CD16 hi ) monocytes, and occurrence of neutrophil precursors in the peripheral blood of severe COVID-19 patients [3][4][5][6][7] . Older age, male sex, chronic lung and cardiovascular diseases, diabetes mellitus, obesity, host genetics, and IFN autoantibodies have also been associated with severe disease and death [8][9][10][11] , but these factors alone do not appear to explain the wide variability in the clinical course of COVID-19. ...