Laurent Guilleminault's research while affiliated with Centre Hospitalier Universitaire de Nancy and other places
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Publications (36)
Background
Using a large dataset, we evaluated prevalence and severity of alterations in liver enzymes in COVID-19 and association with patient-centred outcomes.
Methods
We included hospitalized patients with confirmed or suspected SARS-CoV-2 infection from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) datab...
Purpose:
To determine its cumulative incidence, identify the risk factors associated with Major Adverse Cardiovascular Events (MACE) development, and its impact clinical outcomes.
Materials and methods:
This multinational, multicentre, prospective cohort study from the ISARIC database. We used bivariate and multivariate logistic regressions to e...
Background
COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HIC).
Objectives
The main aims were to compare the frequency of coagulopathy complications in developing countries (...
Introduction:
Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these co...
Background
Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in...
The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World...
DIPNECH is a differential diagnosis of severe asthma with no specific biomarkers. Chronic cough and multiple nodules on CT should prompt clinicians to consider this diagnosis. Differentiating DIPNECH from severe asthma remains crucial. https://bit.ly/3mmFbQn.
Background
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods
International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruit...
Résumé
L’asthme associé à l’obésité est considéré aujourd’hui comme un phénotype à part entière avec des mécanismes physiopathologiques et une prise en charge spécifiques. Les modifications de la mécanique ventilatoire en lien avec l’obésité sont probablement au premier plan dans les mécanismes sous-jacent mais d’autres facteurs tels que la modific...
Résumé
L’allergie alimentaire est une pathologie fréquente qui touche particulièrement l’enfant. La morbi-mortalité est élevée mais peu de traitements sont disponibles. L’éviction de l’allergène est recommandée mais cette option pleine de bon sens a de nombreuses limites dont l’exposition à des allergènes cachés. L’immunothérapie par voie orale (IT...
Résumé
L’asthme et la rhinite allergiques sont les pathologies respiratoires les plus fréquentes. La vision passée de maladies uniques répondant à un seul traitement est maintenant bel et bien révolue. Des phénotypes différents d’asthme, c’est-à-dire des asthmes avec caractéristiques cliniques, biologiques et fonctionnelles communes ont été identif...
Résumé
L’asthme allergique est le phénotype le plus fréquemment observé dans l’asthme y compris l’asthme sévère. L’exploration de l’allergie chez des patients ayant un asthme quelle que soit la sévérité est donc un élément crucial de la prise en charge. Une anamnèse complète et la réalisation de prick tests est systématique chez tous les patients a...
Little is known on the association between clinical factors and coronavirus disease 2019 (COVID‐19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID‐19 hospitalized patients to describe clinical, biological, and virological characteristics at hospital admission and over time, according to mortality up to Da...
Vianney Gruzelle,1 Claire Mailhol,2,3 David W Waters,4 Laurent Guilleminault2,4 1Department of Paediatric Pneumology and Allergology, University Hospital Centre of Toulouse, Toulouse, France; 2Department of Respiratory Medicine and Allergic Diseases, University Hospital Centre of Toulouse, Toulouse, France; 3Mastocytosis Reference Centre and Dermat...
Immunotherapy has become a standard of care in oncology, following the recent approvals of cytotoxic T-lymphocyte-associated protein-4 and programmed cell death-1 inhibitors in lung cancer, melanoma, renal cell carcinoma, Hodgkin's lymphoma, bladder, head and neck cancers. Besides their efficacy, these agents also generate specific immune-related a...
Asthma is a chronic inflammatory airway disorder characterized by a multitude of phenotypes. Epidemiological studies show an increase in asthma prevalence in obese patients regardless of age. The association of asthma and obesity is now considered as a phenotype with its own clinical, biological and functional characteristics. Regarding the pathoph...
Introduction:
The impact of fractional exhaled nitric oxide (FENO) on the management of chronic cough (CC) is still inconclusive. The aim of the present study was to assess whether FENO is a good tool to predict the response to inhaled corticosteroids (ICS) in patients with CC.
Methods:
Patients, referred for investigation of CC, had a FENO meas...
Résumé
La toux est habituellement divisée en deux catégories : la toux aiguë dont la durée est inférieure à 3 semaines et la toux chronique dont la durée est supérieure à 8 semaines. La toux aiguë est secondaire dans un grand nombre de cas à une infection virale des voies aériennes supérieures. Le traitement n’est pas bien codifié et l’efficacité d...
Résumé
L’asthme sévère couramment défini comme réfractaire aux thérapeutiques classiques en particulier à la corticothérapie inhalée (voire systémique) et aux bronchodilatateurs de longue action, reste un problème de santé publique significatif et contribue à la majorité des coûts de santé liés à l’asthme. L’évolution des connaissances physiopathol...
With respective prevalence of 13% and 9.6%, obesity and chronic cough are two common conditions worldwide. The crucial role of obesity has been highlighted in the development and progression of many respiratory diseases. According to the results of epidemiological studies, obesity, particularly abdominal obesity, may also be associated with chronic...
Introduction
La toux chronique, définie par une toux dont la durée est > 8 semaines, est un motif de consultation fréquent. Une enquête a été menée auprès de pneumologues et d’allergologues afin de faire un état des lieux de la prise en charge de la toux chronique en France.
Méthodes
Un questionnaire a été adressé par e-mail à des praticiens en ut...
Introduction:
Blomia tropicalis is a mite that belongs to the superfamily of Glycyphagidae. Initially described as a storage mite, it is now considered as a house dust mite of tropical and sub-tropical areas.
State of the art:
Sensitization to this mite is very common in South America and Southeast Asia. Epidemiological studies have also found s...
Citations
... NEuroCOUGH network aims to develop new understandings on CC, creating a wide European registry and specific specialist-oriented standardized protocols [56]. Starting from a Delphi survey among clinicians of 57 specialist centres from 19 countries, the panel reached consensus on 15 statements concerning the duties of cough specialist centres, the minimum number of assessments required for CC evaluation, the importance of multidisciplinary teams and the need for specific speciality training on this topic [57]. ...
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... Acute respiratory failure is a common presenting condition to the emergency department (ED) and a leading cause of morbidity and mortality in low-income countries (LICs), as recently highlighted by the COVID-19 pandemic [1][2][3][4][5][6]. Effective management of acute respiratory failure in the ED requires an understanding of the underlying causes and the capacity for advanced respiratory support. ...
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... While the ISARIC FUP CRF is just one form, we compared its variables to six studies in ORCHESTRA. An analysis of variables (Fig. 2) with a score of 0, 1 and 2 based on the ORCHESTRA study that includes the respective variable in their CRF, showed the highest number of matching variables or partially matching variables (scores 0,2) for the Long-Term Sequelae (33,32), Fragile population (27,34) and Healthcare Workers (23,16) studies. The high matching score for these three particular studies is consistent with the fact that these CRFs include over 900 variables each across several informational categories. ...
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... In January 2020, the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) [11], in partnership with the World Health Organization (WHO), activated the ISARIC-WHO Clinical Characterisation Protocol and case report form (CRF) to collect data on demographics, illness severity, treatment strategies and outcomes for hospitalized patients with COVID-19 [12,13]. ISARIC hosts data for the largest world-wide cohort of hospitalized COVID-19 patients. ...
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... Detailed definitions of the endpoints are provided in e-Appendix 2, Online Resource. An improvement in LCQ total score of ≥ 1.3 points identified a treatment responder [25,26]. Safety assessments included monitoring treatment-emergent adverse events (TEAEs) at each visit, classified by System Organ Class and Preferred Terms using the Medical Dictionary for Regulatory Activities, version 23.0. ...
... Among the retrospective studies, 18 (29%) were cohort studies, two were longitudinal studies [28,29] and one was a multicentre study [30]. The prospective design was found in two studiesone longitudinal and multinational study [31] and one cohort study [32]. One was reported as an observational study [33] (online suppl. ...
... As an immune antibody therapy, omalizumab has been tested in clinical trials as a monoclonal antibody against immunoglobulin E (IgE) (117). The combination of omalizumab and OIT has achieved promising results for the treatment of food allergies (118). In the future, with an in-depth understanding of the mechanism of food allergy and the identification of therapeutic targets, more targeted antibodies, such as antibodies against Th2 cytokines, will be developed and used in the treatment of food allergy. ...
... 55 Furthermore, a French pharmacovigilance study found that omalizumab was considerably more related with hypertension, ventricular arrhythmia, and venous thromboembolism than mepolizumab, reslizumab, and benralizumab, which are anti-IL-5 mAbs. 56 However, a pooled review of 25 omalizumab-related RCTs and two extension studies found no indication of increased CV risk. 57 Until now, there have only been isolated reports of omalizumab-related arterial and venous thromboembolic events. ...
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... The baseline differences in severe asthma and blood IgE levels may have accounted for the clinical outcomes 93 . By contrast, most clinical studies showed that anti-IL-5 and anti-IL-4 antibodies lowered the risk of CVD in a large database study, case reports and even in patients with atopic dermatitis [96][97][98][99][100] (Table 2). Aside from these clinical studies, MC stabilizers have long been used in asthmatic patients 101 and were successfully tested for experimental atherosclerosis and AAA 102,103 . ...
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... Eligible patients were those who were hospitalized with virologically confirmed COVID-19 by PCR performed on the day of inclusion. The definition criteria of the severity of the disease were stated according to WHO and French National Health Agency guidelines applied to the inclusion of the French National COVID-19 cohort "French cohort" [20]. Viral loads were quantified by real-time semi-quantitative reverse transcriptase polymerase chain reactions (RT-PCR) using either the Charité WHO protocol (testing the E gene and RdRp) or the Pasteur institute assay (testing the E gene and two other RdRp targets, IP2 and IP4). ...
