Lauren O'Connor's research while affiliated with Agricultural Research Service and other places
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Publications (49)
Background:
The degree of food processing may be an important dimension of diet in how it relates to health outcomes. A major challenge is standardizing food processing classification systems for commonly used datasets.
Objectives:
To standardize and increase transparency in its application, we describe the approach used to classify foods and be...
Observational research suggests higher red and processed meat intakes predict greater risks of developing or dying from cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM), but this research limits causal inference. This systematic review of reviews utilizes both observational and experimental research findings to infer causality of t...
Background:
High energy intake from non-nutrient dense sources correlates with poorer diet quality.
Objectives:
To, 1) estimate total energy intake, and energy from solid fats and added sugars, and combined (SOFAS), and identify their top food category sources for ages 2-18 years in 2015-2018, and 2) describe trends over time in 2009-2018.
Desi...
Objectives
Salmon consumption may promote cardiovascular (CV) health through nutrients such as omega-3 fatty acids (n-3 FAs) or other yet unidentified compounds. Metabolomics allows for the comprehensive analysis of small molecules in foods and human samples. The objectives of this study were to: 1) identify compounds present in salmon that were in...
Objectives
Salmon is a commonly consumed fish rich in astaxanthin carotenoids and polyunsaturated fatty acids with inflammatory and metabolic benefits. This study investigated concentrations of astaxanthin and fatty acids from salmon type (wild vs. farmed) and temperature changes (raw vs. cooked), and the effect of salmon consumption on human plasm...
Objectives
To describe processing degree of complimentary foods and beverages (CFBs) according to NOVA for infants and toddlers in the US and describe how each NOVA group contributes to nutrients and food groups of concern identified by the 2020–2025 US Dietary Guideline for Americans.
Methods
Using day 1 dietary recall data from 2013–18 NHANES, w...
Objectives
To identify metabolomic markers that differed between dietary patterns (DP) that are either high in or void of ultra-processed foods (UPFs) according to NOVA.
Methods
A secondary analysis of a randomized, crossover, controlled feeding trial in which 20 domiciled, healthy participants (mean ± SD: 31 ± 7 years, BMI 22 ± 11.6, 50% female)...
Objectives
Foods are comprised of thousands of compounds that may be absorbed upon ingestion. Metabolomics offers the unprecedented capability of measuring these small molecules to discover biomarkers of intake and examine how dietary patterns may exert their effects on health. The objectives of this study were to: 1) perform metabolomics analyses...
Objectives
Beyond diet quality, the timing of eating and energy intake within the 24 hr day (24 hr TOE) may have important implications for chronic disease risk, and research in this area (i.e., chrononutrition) is rapidly growing. The 2020 Dietary Guidelines Advisory Committee recommended the development of consistent terminology to address the la...
Purpose of Review
To summarize recent evidence from randomized controlled feeding trials (RCTs) on the effects of consuming plant- and animal-based protein-rich foods on cardiovascular health of adults.
Recent Findings
Results from meta-analyses of RCTs exemplify the importance of considering relative effects of protein-rich foods, i.e., when inta...
Heterogeneity in meat food groups hinders interpretation of research regarding meat intake and chronic disease risk. Our objective was to investigate how heterogeneity in red meat (RM) and poultry food groups influences US population intake estimates. Based on a prior systematic review, we created an ontology of methods used to estimate RM [1= unpr...
A Mediterranean-style eating pattern (MED-EP) may include moderate red meat intake. However, it is unknown if the pro-atherogenic metabolite trimethylamine N-oxide (TMAO) is affected by the amount of red meat consumed with a MED-EP. The results presented are from a secondary, retrospective objective of an investigator-blinded, randomized, crossover...
Background
Standardized methods are needed to investigate intake patterns of processed meat subtypes, considering health concerns surrounding processed meat intake.
Objectives
The objectives of this study were to create a standardized method of disaggregating processed meat into processed red meat and processed poultry and describe intake patterns...
Importance
The childhood obesity rate has been steadily rising among US youths during the past 2 decades. Increasing evidence links consumption of ultraprocessed foods to excessive calorie consumption and weight gain, but trends in the consumption of ultraprocessed foods among US youths have not been well characterized.
Objective
To characterize t...
Objectives
Limitations in dietary assessment methodology lead to broad and inconsistent red meat intake categories. For example, red meat is often combined with processed meat, which includes processed poultry. Our objective was to quantitatively assess how these limitations influence red meat intake estimates of the U.S. population.
Methods
Three...
Objectives
To develop a tool for researchers to augment the ASA24 database and include novel foods, beverages, and supplements for use in their study.
Methods
ASA24 uses nutrient values for foods and beverages from USDA's Food and Nutrient Database for Dietary Studies (FNDDS) and supplement values from the National Health and Nutrition Examination...
Objectives
To develop a sleep assessment module in ASA24 to capture self-reported sleep behavior as an optional enhancement to the ASA24 Dietary Assessment Tool for adults.
Methods
Multiple self-reported sleep assessment tools were considered in module development, including the National Sleep Foundation Sleep Diary, the Activities Completed over...
Background and aims:
Public interest in pre- , pro-, and synbiotic products is increasing because of interactions between gut microbiota and human health. Our aim was to describe non-food (from dietary supplements or medication) pre, pro-, and synbiotic use by U.S. adults and children and reported reasons.
Method:
Using data from the National He...
Our objective was to conduct a systematic review and meta-analysis to assess the effects of total red meat (TRM) intake on glycemic control and inflammatory biomarkers using randomized controlled trials of individuals free from cardiometabolic disease. We hypothesized that higher TRM intake would negatively influence glycemic control and inflammati...
Objectives
Astaxanthin, a predominately marine-source carotenoid, is the subject of a large number of studies for its antioxidant and anti-inflammatory properties. Astaxanthin is not generally a primary carotenoid in human plasma due to relatively low dietary intake. Salmon is the one of the few dietary sources of astaxanthin in typical American di...
Objectives
Higher red meat intake is associated with increased risk of cardiometabolic diseases, but causation of this relationships is unclear. This umbrella systematic review qualitatively assessed causality between red meat intake and cardiometabolic diseases.
Methods
Two researchers independently screened and crosschecked 524 articles from MED...
Objectives
To identify top dietary sources of energy, empty calories, added sugars, and solid fats among 2–18 year old children and adolescents in the U.S. and describe trends.
Methods
Day 1 24-hour dietary recalls from the NHANES Survey were categorized according to the What We Eat in America Food categories and used to examine food sources (perc...
Objectives
Cured animal protein foods are not often differentiated by animal source in dietary data, e.g., cured poultry is commonly grouped with cured red meat. Using the USDA's Food Patterns Equivalents Database (FPED), our objective was to disaggregate the ‘cured meat’ FPED variable into cured red meat (CRM) and cured poultry (CP) to describe me...
Background:
A Mediterranean-style eating pattern is consistently associated with a decreased diabetes risk in Mediterranean and European populations. However, results in U.S. populations are inconsistent. The objective of this study was to assess whether a Mediterranean-style eating pattern would be associated with diabetes risk in a large, nation...
This systematic review and landscape analysis describes patterns in dietary meat (skeletal muscle and associated tissues from mammalian, avian, and aquatic species; i.e., muscle foods) categories (CAT) and descriptions (DESCR) used throughout nutrition-related chronic disease literature, as there is anecdotally noted variation. A total of 1020 CAT...
Objectives
To determine the effect of adopting a Mediterranean-style eating pattern with different quantities of lean unprocessed red meat on the plasma concentration of Trimethylamine N-Oxide (TMAO), an emerging potential cardiovascular disease risk factor, in middle-aged adults classified as overweight or obese.
Methods
Thirty-nine adults (12 ma...
Objectives:
Qualitatively, nutrition science and policy experts recognize that variation in muscle food categories (CAT) and descriptions (DESCR) hinder effective translation of research into policy. The purpose of this systematic review was to quantitatively describe CAT and DESCR patterns in nutrition-related chronic disease literature.
Methods...
Objectives:
Our objective was to assess effects of total red meat consumption on markers of glycemic control and inflammation using RCT data. Based on observational studies suggesting that higher red meat consumption increases type 2 diabetes risk, we hypothesized that higher red meat consumption would negatively influence markers of glycemic cont...
Background:
Findings among randomized controlled trials evaluating the effect of red meat on cardiovascular disease risk factors are inconsistent. We provide an updated meta-analysis of randomized controlled trials on red meat and cardiovascular risk factors and determine whether the relationship depends on the composition of the comparison diet,...
Background:
Reducing red meat intake is commonly recommended. Limited observational studies suggest that healthy eating patterns with red meat are associated with improved quality of life.
Objective:
The secondary objectives of this randomized crossover controlled-feeding trial were to assess the effects of following a Mediterranean-style eating...
Adherence to healthy eating patterns (HEPs) is often short-lived and can lead to repetitive attempts of adopting—but not maintaining—HEPs. We assessed effects of adopting, abandoning, and readopting HEPs (HEP cycling) on cardiovascular disease risk factors (CVD-RF). We hypothesized that HEP cycling would improve, worsen, and again improve CVD-RF. D...
Background:
A Mediterranean-style eating pattern (Mediterranean Pattern) is often described as being low in red meat. Research shows that lean, unprocessed red meat can be incorporated into healthy eating patterns to improve cardiometabolic disease (CMD) risk factors.
Objective:
We assessed the effects of consuming different amounts of lean, unp...
Promoting sustainable eating patterns is an approach to limiting the environmental impact of resource-intensive food production. Incorporating the concept of sustainable eating patterns into the Dietary Guidelines for Americans (DGA) would be congruent with established federal policy goals, but societal, economic, and agricultural impacts also need...
Dietary recommendations regarding consumption of muscle foods, such as red meat, processed meat, poultry or fish, largely rely on current dietary intake assessment methods. This narrative review summarizes how U.S. intake values for various types of muscle foods are grouped and estimated via methods that include: (1) food frequency questionnaires;...
Consumption of red meat in the United States has progressively declined over the past 35 years. This occurred in conjunction with public recommendations to reduce red meat intake, based mainly on associations between higher red meat intake and increased chronic disease risk. This narrative review presents and discusses results from both observation...
Context:
The impact of dietary protein on body composition changes after older adults purposefully lose weight requires systematic evaluation OBJECTIVE: : This systematic review and meta-analysis assessed the effects of protein intake (<25% vs ≥25% of energy intake or 1.0 g/kg/d) on energy restriction-induced changes in body mass, lean mass, and f...
Previous research supports that consumption of resistant starch and guar gum independently influence insulin-mediated glucose responses to meals. This research assessed a novel co-processed fiber composite ingredient (FC) comprised of whole-grain high-amylose maize flour and viscous guar gum on glucose and insulin responses to co-consumed and subse...
To determine whether a 21-day milk-drinking intervention could reverse milk aversion.
Participants consumed increasing amounts of cow's milk for 21 days. Milk and dairy consumption, aversion, and likeness were assessed pre- and post-intervention and at 3 and 6 months post-intervention.
A large Midwestern university.
Twenty-seven milk-averse individ...
Ingestive and exercise behaviors are important determinants of whole body energy balance and weight control. An acute bout of exercise generates a transient energy deficit, which is only partially compensated for by food intake at the next eating occasion or within the next day (loose dietary coupling). Such an energy deficit, when repeated chronic...
Objective:
To evaluate the acceptance and effectiveness of repetitive nutrition-related text messages on college students' nutrition knowledge and fruit and vegetable consumption.
Participants:
One hundred fifty undergraduate (18-24 years old) non-health major students with a texting mobile phone.
Methods:
The intervention group received biwee...
High-protein (>30% of energy from protein or >1.2 g/kg/day) and moderately high-protein (22% to 29% of energy from protein or 1.0 to 1.2 g/kg/day) diets are popular for weight loss, but the effect of dietary protein on bone during weight loss is not well understood. Protein may help preserve bone mass during weight loss by stimulating insulin-like...
Citations
... Red meat is one of the most controversial sources of highquality protein rich in EAAs. Numerous epidemiologic studies report the association of red meat with negative health outcomes including cardiovascular disease and type 2 diabetes leading to dietary recommendations to reduce red meat consumption [29]. However, the association of red meat with negative cardiovascular disease outcomes may be confounded by overall lifestyle choices posing the question, Is the association with negative health outcomes due to red meat or the nutritional and lifestyle "company" it keeps? ...
... 75 The Automated Self-Administered 24-h ('ASA-24') recall developed by the National Cancer Institute now includes questions related to timing of sleep episodes and should be used to capture information on dietary intakes and sleep timing in free-living situations. 76 ...
... Indeed, unprocessed red meat, especially ruminant meat, is a top source of bioavailable nutrients commonly lacking in diets globally, including iron, zinc, and vitamin B 12 , and essential amino acids [20,30,33,34]. Further, lean red meat can support healthy aging, including benefits to muscle health and protection against sarcopenia [38], and has been found to be compatible with good metabolic health in multiple randomized clinical trials when consumed as part of high-quality diets sufficiently high in fruits, vegetables, and fiber [39]. Third, dietary cholesterol is always scored negatively despite its limited influence on plasma cholesterol [40], inevitably penalizing ASFs. ...
... Diet is a key risk-modifying factor for many chronic diseases and evidenc association of meat consumption with various chronic diseases has been rathe sistent. Indeed, the study of O'Connor et al. [30] provides evidence that heterog meat types hinders both the interpretation of meat intake and related chronic dise This short review is focused on the chronic health effects of red meat, white m processed meat as defined by WHO [31] with most evidence based on data fro term prospective studies. ...
... To investigate whether dietary components influence plasma TMAO concentrations, researchers have compared foods with different TMAO precursors (e.g., eggs containing phosphatidylcholine versus meat containing carnitine) [12], foods with the same TMAO precursor in different food matrices (e.g., eggs containing phosphatidylcholine versus soup supplemented with choline-bitartrate) [13], or the same TMAO-precursor-containing food in different doses [14] or on different dietary backgrounds (e.g., eggs containing phosphatidylcholine on a low-versus high-fat diet) [15]. In aggregate, these studies provide context for how specific nutrients, the food matrix, and the diet pattern impact the precursor's effect on TMAO concentrations. ...
... Most of the included reviews did not disaggregate processed meat into independent processed poultry and processed red meat intake categories. About 30% of the processed meat consumed in the US is processed poultry (O'Connor, Wambogo, et al. 2021) therefore, we assume that the PM category in our review includes both processed red meat and processed poultry. Unprocessed poultry fell outside of the scope of our umbrella review. ...
... Currently, major concerns are the excessive consumption of ultra-processed foods (UPFs) and take-away food [10]. UPFs contribute 25-67% of the total energy among youths [10,26]. Although the data on the consumption of take-away food remain unclear, the COVID-19 pandemic lockdown policy has led to a rapid expansion in its consumption [27,28]. ...
... Vücutta meydana gelen ağırlık kaybı sonrasında vücut bileşimi ve kan basıncında da olumlu farklılık gözlemlenirken, enerjinin sınırlandırılmasıyla birlikte vücut yağ kütlesindeki düşüş ve yağsız vücut kütlesinin korunması protein içeriği yüksek diyet ile bağdaşlaştırılmışrı (29). 18 randomize kontrollü çalışmanın incelendiği bir meta analizde 50 yaş üstü yetişkinlerde kilo verirken yüksek protein tüketiminin yağsız vücut kütlesini korumada daha etkili olduğu görülmüştür (30). Bin kişiden fazla katılımcı içeren 24 çalışmadan oluşan bir meta analiz incelendiğinde, yüksek proteinli diyetler ve standart/normal proteinli diyetler karşılaştırılmıştır. ...
... We are interested in Methods of intervention that will allow "lactose intolerant" individuals to learn that they can consume dairy foods without experiencing gastrointestinal symptoms. 6 Finally, we are working with the dairy and pharmaceutical industries to attempt to develop food products that are well tolerated by the lactose maldigesters. 7 ...
... The average value of yogurt from two interviews was used in this study. To assess exposure to probiotic supplements, text-mined was used to identify keywords for products with prebiotics, probiotics, and synbiotic elements in the dietary supplement questionnaire (DSQ) [14]. Participants who consumed yogurt or probiotic supplements were probiotic exposure [15]. ...