Laura Russell's research while affiliated with Environmental Science & Research and other places

Publications (4)

Article
The analysis of forensic DNA profiles is complicated by the presence of undesirable artefactual peaks such as stutter, pull-up, and dye blobs. We describe the developmental validation of FaSTR™ DNA analysis software, which can assist with the streamlined analysis of forensic DNA profiles. A total of 3403 single-source and mixed DNA profiles generat...
Article
The interpretation of DNA profiles typically starts with an assessment of the number of contributors. In the last two decades, several methods have been proposed to assist with this assessment. We describe a relatively simple method using decision trees, that is fast to run and fully transparent to a forensic analyst. We use mixtures from the publi...
Article
Until recently, forensic DNA profile interpretation was predominantly a manual, time‐consuming process undertaken by analysts using heuristics to determine those genotype combinations that could reasonably explain a recovered profile. Probabilistic genotyping (PG) has now become commonplace in the interpretation of DNA profiling evidence. As the co...
Article
In 2015 the Scientific Working Group on DNA Analysis Methods published the SWGDAM Guidelines for the Validation of Probabilistic Genotyping Systems [1]. STRmix™ is probabilistic genotyping software that employs a continuous model of DNA profile interpretation. This paper describes the developmental validation activities of STRmix™ following the SWG...

Citations

... These PROVEDIt profiles have been used for the validation of PG or analysis software, or to assess the performance [13][14][15][16][17][18][19], comparison of different PG methods [20,21], and to evaluate tools that assign the number of contributors to profiles [22,23]. However, the PROVEDIt dataset is limited to a relatively small number of kit and instrument types and range of contributors. ...
... These PROVEDIt profiles have been used for the validation of PG or analysis software, or to assess the performance [13][14][15][16][17][18][19], comparison of different PG methods [20,21], and to evaluate tools that assign the number of contributors to profiles [22,23]. However, the PROVEDIt dataset is limited to a relatively small number of kit and instrument types and range of contributors. ...
... All the 564 log 10 LR B ≥ 3 corresponded to a component of the mixture where the STRmix™ assigned posterior mean template was less than 588 rfu. The STRmix™ template value is the mean of the posterior burn-in MCMC iterations used for template in the biological model implemented by STRmix™ [17]. The STRmix™ template value aligns with the approximate peak heights of alleles at the left-hand side of the electropherogram (before any degradation is applied). ...
... Validation studies have been published on a variety of semi-and fully continuous probabilistic genotyping software programs. Some of these include the semi-continuous Lab Retriever [12] and LRMix/LRMixStudio [13][14][15] and the fully continuous TrueAllele ® [16][17][18][19], EuroForMix [20,21], and STRmix™ [22][23][24]. ...