Laura Adiene González-Escalante's research while affiliated with Mexican Institute of Social Security and other places

Publications (10)

Article
Full-text available
The emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis strains threaten the control of tuberculosis. New antitubercular dihydrosphingosine analogs, named UCIs, have been evaluated in preclinical studies but their cellular and molecular mechanisms of action against M. tuberculosis are still unknown. The aim of this study was to evalua...
Article
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Variants of 8q24 locus have been associated with prostate cancer (PCa) susceptibility. This study aims to analyze the genetic basis of PCa susceptibility in Mexican men by analyzing SNPs in the 8q24 locus for the first time. A case-control study was performed in 875 men recruited from the Mexican Social Security Institute, 326 patients with PCa, an...
Article
Background and aims To assess the relevance of the slow acetylator phenotype based on NAT2 genotypes, among patients with pulmonary tuberculosis (PTB) that developed hepatotoxicity after first-line tuberculosis treatment in a Northeastern Mexican population. Methods Ninety one PTB patients were included, 7 of them developed hepatotoxicity. NAT2 SN...
Article
Full-text available
Background: Mortality due to tuberculosis (TB) has increased due to the development of drug resistance, the mechanisms of which have not been fully elucidated. Our research group identified a low expression of lipF gene in Mycobacterium tuberculosis clinical isolates with drug resistance. The aim of this work was to evaluate the effect of lipase F...
Article
Tuberculosis drug resistance (DR) is a global problem that is not fully elucidated. Previously, overexpression of esxG and esxH genes was reported in a multidrug-resistant (MDR) Mycobacterium tuberculosis isolate compared with a reference H37Rv strain. To evaluate the roles of esxG and esxH in DR, analysis of their regulatory and coding sequences i...
Article
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Arsenic is a worldwide environmental pollutant that generates public health concerns. Various types of cancers and other diseases, including neurological disorders, have been associated with human consumption of arsenic in drinking water. At the molecular level, arsenic and its metabolites have the capacity to provoke genome instability, causing al...
Article
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Wildlife near agricultural lands is exposed to pesticides, particularly organophosphorus and carbamates, where birds appear to be more sensitive to their toxic effects than other vertebrates. One of the main effects of pesticides is the disruption of the nervous system through the inhibition of cholinesterase enzymes. The aim of this study was to d...
Article
Understanding drug resistance in Mycobacterium tuberculosis requires an integrated analysis of strain lineages, mutations, and gene expression. Previously, we reported the differential expression of esxG, esxH, infA, groES, rpmI, rpsA, and lipF genes in a sensitive M. tuberculosis strain and in a multidrug-resistant clinical isolate. Here, we have...
Article
Full-text available
Mycobacterium tuberculosis has developed resistance to anti-tuberculosis first-line drugs. Multidrug-resistant strains complicate the control of tuberculosis and have converted it into a worldwide public health problem. Mutational studies of target genes have tried to envisage the resistance in clinical isolates; however, detection of these mutatio...
Article
Full-text available
Agricultural lands are exposed to pesticides continuously, which impact on habitat of wild species, such birds. The purpose of this study was to determine the plasma cholinesterase activity in two passeriform wild birds, the house finch (Carpodacus mexicanus) and the house sparrow (Passer domesticus), from agricultural land with exposure to pestici...

Citations

... Papillary thyroid carcinoma susceptibility candidate 1 (PTCSC1) in locus 8q24 has been identified, by GWLA, in a family with PTC, benign thyroid nodules and melanoma, as a predisposing locus for PTC (45). More recent studies have also identified variants in this 8q24 locus associated with risk of prostate cancer, colorectal cancer, breast cancer, bladder cancer, stomach cancer, glioma and thyroid cancer (132)(133)(134). ...
... (40) Also, trying to prevent adverse events such as DIH, many authors have already proposed, in quite distinct populations, the development of a NAT2 genotyping test to be applied to patients with TB diagnosis previously to TB treatment. (41,42,43,44) In this way, different genotyping panels have been proposed, revealing greater accuracy of either five or seven-SNPs panels. (12,45) Beyond that, one research performed in the Brazilian population suggested the four-SNPs panel (c.191G>A, c.341T>C, c.590G>A, and c.857G>A) as the most appropriate test to predict the individual NAT2 acetylation status with accuracy up to 100%. ...
... Another STR resistance mechanism is likely related to lipF (Rv3487c), which encodes for a lipase with phospholipase C and carboxylesterase activities. The reduced expression of this gene is thought to contribute to the development of resistance to STR [65]. Moreover, the M. tuberculosis homocysteine synthase MetC (Rv3340), a key enzyme of the methionine synthesis pathway, was hypothesized to promote STR resistance. ...
... [9] Knockdown (antisense) strategy has been well established for identifying the pathogenic and virulent determinants in mycobacteria. [11,12] Therefore, the present study was conducted to validate the role of hadC in M. fortuitum biofilm formation using knockdown strategy. For this, we constructed and characterized M. fortuitum hadC knockdown and over-expressing strains. ...
... Recently it has been shown that the oncogene 26S Proteasome non-ATPase regulatory subunit 10 (PSMD10) induces STAT3 activation in a tumor microenvironment [16]. Although arsenic can modify the expression of several genes [21,22], and some oncogenes such as STAT3 and PSMD10 have been associated with malignant transformation of hepatocytes [23][24][25][26], our knowledge of arsenic's targets and effects on cancer etiology are unclear. Evidence has been accumulating in recent years about the important role that PSMD10 plays in hepatocellular carcinoma, for instance it has been shown to prevent the degradation of Octamer-binding transcription factor 4 (Oct4), regulates Retinoblastoma 1 (Rb1), tumor protein 53 (Tp53) and cisplatin sensitivity. ...
... In birds, studies have evaluated the activity of this enzyme. In northeast Mexico, cholinesterase activity decreased by 29-49% because of possible exposure to pestivcides (Ruvalcaba-Ortega et al. 2017). In Spain, Oropesa et al. (2017) observed a decrease in plasma cholinesterase activity under in vitro conditions in samples of griffon vultures (Gyps fulvus) exposed to carbamates, suggesting that it is a suitable biomarker for monitoring the exposure of this toxin. ...
... In this regard, numerous studies demonstrate the value of WGS in predicting DR-M.tb phenotypes from the M.tb genome sequenced directly from clinical specimens (e.g., sputum) (Groschel et al., 2018;Cohen et al., 2019b) (Table 2). Importantly, WGS has provided new insights into the complex underlying molecular mechanisms of M.tb drug resistance thanks to its nucleotide-level resolution (Gonzalez-Escalante et al., 2015;Yu et al., 2015;Coll et al., 2018) ( Table 2). Of interest, studies of M.tb clinical isolates collected from the same patient at a single time point (parallel isolates) or at a different time points (serial isolates) during active TB disease progression and/or drug treatment, revealed within-host M.tb genomic diversity and microevolution events (O'Neill et al., 2015;Ley et al., 2019;. ...
... • Understand mechanisms underlying Mtb single and multi-drug resistance in vitro. Keren et al., 2011;Chatterjee et al., 2013;Knegt et al., 2013;Peñuelas-Urquides et al., 2013;Eldholm et al., 2014;Blondiaux et al., 2017;Zheng et al., 2018 • Identify bacterial candidates for drug targeting. Betts et al., 2002;Talaat et al., 2004;Gao et al., 2005;Cappelli et al., 2006;Rachman et al., 2006b;Murphy and Brown, 2007;Balázsi et al., 2008;Fontán et al., 2008a;Rustad et al., 2008;Deb et al., 2009;Salamon et al., 2014;Defelipe et al., 2016;Aguilar-Ayala et al., 2017;Sharma et al., 2017;Banerjee et al., 2020;Saini et al., 2020 • Unravel the mechanism of action of novel compounds. ...
... When it is possible to collect only small volumes of blood samples (in studies such as ours that sample passerines), one must choose a single AChE endpoint, which also allows comparison across species. We selected the Ellman method, with acetylthiocholine as the substrate (González-Escalante et al. 2013;Stuber et al. 2018), due to the high specificity of the AChE (Miao et al. 2010) and the availability of data in the literature to make comparisons between species and sampling sites. On the other hand, characterizing and selecting the most appropriate substrate in each species for acetyl, butyryl, or propionyl ChEs is the procedure indicated when the first step in biomonitoring is to identify a focal species (European Food Safety Authority 2009). ...