Laura A. Frey-Law's research while affiliated with University of Iowa and other places

Publications (15)

Article
A growing number of individuals report prolonged symptoms following acute Coronavirus-19 (COVID-19) infection, known as post-COVID-19 condition (post-COVID-19). While studies have emerged investigating the symptom sequelae of post-COVID-19, there has been limited investigation into the characterization of pain, fatigue, and function in these indivi...
Article
Multisensory sensitivity (MSS) to non-painful stimuli has been identified as a risk factor for the presence of coexisting chronic pain conditions (COPCs). However, it remains unclear whether MSS can differentiate pain phenotypes involving different levels of central sensitivity. Both pain-free and those with chronic pain, particularly fibromyalgia...
Article
In clinical populations, it can be challenging to identify the underlying mechanisms of chronic pain. Referred pain (RP) from an intramuscular infusion provides a clinically-relevant model of centrally-mediated pain that can be used to investigate factors contributing to nociplastic pain. Further, quantitative sensory testing (QST) is commonly used...
Article
Many chronic pain conditions tend to co-occur, termed chronic overlapping pain conditions (COPCs), which may reflect certain degree of common underlying pathophysiology. Therefore, it would be of value to compare the phenotypic characteristics of COPCs. The purpose of this study was to perform a secondary analysis of COPC survey data targeting indi...
Article
Resistance training-based exercise is commonly prescribed in the clinic for the treatment of chronic pain. Mechanisms of aerobic exercise for analgesia are frequently studied, while little is known regarding resistance training mechanisms. We developed a resistance training model in mice and hypothesized resistance training would protect against de...
Article
Objectives: To examine whether physical activity (PA) was associated with fatigue, and quantify the extent of potential mediation through depressive symptoms or physical function (PF) on the relationship between PA and fatigue in symptomatic knee osteoarthritis (KOA). Method: This longitudinal study used data from the Multicenter Osteoarthritis St...
Article
Full-text available
A three-compartment controller model (3CC) predicts muscle fatigue development. Determination of fatigue (F) and recovery (R) model parameters is critical for model accuracy. Numerical methods can be used to determine parameter values using maximum voluntary contractions (MVCs) as input. We tested the effects of using reduced MVC data on parameter...
Article
Full-text available
Purpose: Some individuals with chronic pain find daily life sensations (eg, noise, light, or touch) aversive. This amplification of multisensory sensations has been associated with centrally mediated plasticity; for example, greater multisensory sensitivity (MSS) occurs in patients with fibromyalgia than rheumatoid arthritis. However, whether MSS...
Article
Objective Adults with radiographic knee OA (rKOA) are at increased risk of mortality and walking difficulty may modify this relation. Little is known about specific aspects of walking difficulty that increase mortality risk. We investigated the association of walking speed (objective measure of walking difficulty) with mortality and examined the th...
Article
Objective measurement of physical activity (PA) using accelerometers has become increasingly popular across recreational and clinical applications. However, the effects of multiple processing algorithms, filters, and corrections on PA measurement variability may be under‒appreciated. Objective: To examine how lifestyle PA estimates are impacted b...
Article
Although the rotator cuff muscles are susceptible to fatigue, shoulder fatigue studies reporting torque decline during intermittent tasks are relatively uncommon in the literature. A previous modification to the three-compartment controller (3CC) fatigue model incorporated a rest recovery multiplier (3CC-r model) to represent augmented blood flow t...

Citations

... We did not collect data on radiological severity of knee OA, which could have provided more insights regarding the generalizability of the results to people with a more severe knee OA diseases stage and thus can be a topic for future research. Although the majority of the studies were limited to less than 50 participants, cohort studies such as the Osteoarthritis Initiative (n > 1000) [70] or the Multicentre Osteoarthritis Study (n > 400) [61] provide convincing evidence that wearable technology can be used in a large scale in a real-world setting in people with knee OA. Few studies collected information on race/ethnicity, despite its considerable significance for outcomes and disparities [87]. ...
... However, before fatigue models can be integrated into ergonomics use, validation against in-vivo muscle fatigue and recovery is essential (Potvin and Fuglevand, 2017;. Several factors can influence both the rate of fatigue, and likely the rate of recovery, including the accumulation of fatigue specific to different types of motor units (Frey-Law et al., 2021;Potvin and Fuglevand, 2017;. Furthermore, links between the accumulation of muscle fatigue and the development of MSD are scarce, limiting the use of multi-task fatigue accumulation assessment for MSD prevention, per se (Neumann et al., 2020). ...
... Sensory Sensitivity has been linked to increased sensitivity to pain in deep tissues. In such a way it has been suggested that people with this pattern amplify sensations, turning some sensations of daily life into aversive and painful experiences, which could affect their physical health (Wang et al., 2020). ...
... Individuals with radiographic patellofemoral OA increased the time to complete the 20meter walk test by 1.69 seconds from baseline to 7-year follow-up, and individuals with symptomatic patellofemoral OA increased the time to complete the 20-meter walk test by 1.91 seconds, which is outside the normal variability for the 20-meter test. This is of importance, as walking 0.2m/s slower over-time during 20-meter walk test has been associated with increased mortality in individuals with knee OA [31]. Individuals without patellofemoral OA also took 0.38 seconds longer to complete the 20-meter walk test at 7 years than at baseline; however, this is within the normal variability for the test. ...
... There is evidence that humans use such strategy across domains, such as in causal reasoning [20] or perception [31]. In human-computer interaction, researchers have leveraged RL to automate the sequence of user actions in a KLM framework [49] or to predict fatigue in volumetric movements [11]. It was also used to explain search behavior in user interfaces [83] or menus [13] and as a model for multitasking [41]. ...
... However, signals derived from wrist accelerometers could be affected by accelerations related to arm movements not necessarily associated with higher PA-related energy expenditure (EE) (Hildebrand et al., 2014;Ellis et al., 2016). This has led some devices to implement conversion algorithms (equations or filters) that attempt to standardize the levels of accelerometer-derived PA indices (e.g., EE levels), regardless of the recording site (e.g., hip or wrist; McMinn et al., 2013;Mandigout et al., 2019;Mueller et al., 2020;Nuss et al., 2020;. However, as mentioned for epoch lengths, it remains to be defined whether the accelerometer position (even applying data correction schemes to make different recording sites comparable) determines the strength of the association between PA indices and the arterial status. ...
... When an athlete is fatigued, it is generally manifested as slow reflection, inattention, and muscle move-ment perception, and accurate sense of rhythm, speed, distance, and spatial orientation is weakened [18]. At this time, the concept of various actions has certain difficulty and fuzziness, and exhaustion is the expression of its accuracy [19]. The generation of fatigue can be roughly divided into three types: one is physical fatigue; the other is pathological fatigue; and the third is psychological fatigue [20][21][22]. ...