Larry Tang's research while affiliated with George Mason University and other places
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Publications (2)
Evaluating the accuracy (ie, estimating the sensitivity and specificity) of new diagnostic tests without the presence of a gold standard is of practical meaning and has been the subject of intensive study for several decades. Existing methods use 2 or more diagnostic tests under several basic assumptions and then estimate the accuracy parameters vi...
The basket trial is a recent development in the clinical trial practice. It conducts the test of the same treatment on several different related diseases in a single trial, and has the advantage of reduced cost and enhanced efficiency. A natural question is how to assess the performance of the group sequential basket trial against the classical gro...
Citations
... Since the true disease status is likely unknown, indirect methods are often used for the evaluation of diagnostic sensitivity and specificity. Methods and problems regarding the assumptions of such approaches have been widely discussed [10][11][12][13][14][15][16][17][18][19][20]. ...
