Larry H. Taber’s research while affiliated with Baylor College of Medicine and other places

... There is limited literature describing the clinical course and optimal management of iatrogenic meningitis caused by N. sicca/subflava. Infections of the central nervous system caused by this organism occur rarely; most reported cases are in the pediatric population (3,4). In the literature describing illness in adults, 4 cases of N. sicca meningitis are described, 1 of which was an iatrogenic case: a complication of ventriculostomy (5). ...

Reference:

Iatrogenic Meningitis Caused by Neisseria sicca/subflava after Intrathecal Contrast Injection, Australia

... Similarly, in 1993, Yagupsky et al. observed that 14/25 (56%) patients with K. kingae infection had a concomitant upper respiratory tract infection or stomatitis [14]. In addition to seasonal distribution of K. kingae infection, the putative role of respiratory virus to facilitate tissue invasion by bacteria was suggested, as previously described with Haemophilus infuenzae b [15]. ...

Reference:

Kingella kingae and Viral Infections

... All susceptible isolates by the standardized disc agar diffusion test, having inhibition zone diameters of 20 mm or greater, had MICs of 2 /tg/mL or less. Isolates having borderline susceptibility of 1 fig/mL or 2 fig/mh were somewhat more frequent for penicillin (9) than for ampicillin (3). None of the isolates had MICs of 4 /ig/mL. ...

Reference:

Antimicrobial Resistance in Haemophilus Isolates: A Minnesota Experience and Literature Review

... Such competitive pressure has been observed in the form of cross protection in mouse studies that showed e.g. a protective effect of live attenuated influenza vaccine administration on RSV replication [5] and influenza infection on RSV severity [6], mediated by the innate immune system. Population level evidence for the effect of cross-protection on influenza and RSV epidemiology, however, is largely of observational nature: a lack of coincidence in peak timings [7,8], changes in RSV peak timing following unusual influenza seasons [9][10][11][12][13][14] and alternating infection patterns [15]. ...

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Evidence for influenza and RSV interaction from 10 years of enhanced surveillance in Nha Trang, Vietnam, a modelling study

... Reports of protective efficacy against laboratory-confirmed influenza illness have varied between 60% and 95% when the influenza vaccine strains matched the predominant circulating influenza virus [14][15][16] and between 44% and 57% when there was a partial match of circulating and vaccine strains. Lower efficacy has been reported in children <5 years of age compared with older children [16][17][18][19][20]. Furthermore, in these young children (eg, <36 months of age), the percentage that achieve seroprotective titers to different influenza virus vaccine strains varied from 30% to 100% after 2 doses [10,17,[21][22][23]. A number of immunologic mechanisms have been proposed to explain these observations. ...

Reference:

Safety and Immunogenicity of Full-Dose Trivalent Inactivated Influenza Vaccine (TIV) Compared With Half-Dose TIV Administered to Children 6 Through 35 Months of Age

... На сьогодні існує чотири варіанти вірусу грипу: типи А, В, С і D. Віруси грипу (ВГ) типу А є причиною всіх відомих великих епідемій і пандемій, хоча деякі легкі епідемії вірусу грипу типу B також були описані [1][2][3][4]. ВГ типу А поділяють на підтипи відповідно до їхгіх двох поверхневих глікопротеїнів: гемаглютиніну (H) та нейрамінідази (N) [5,6]. Щодо глікопротеїну H, виділено 18 функціональних антигенних підтипів (від H1 до H18). ...

Reference:

Circulation of abnormal isolates of H13 subtype influenza virus among wild water birds

... Linezolid is both bactericidal and bacteriostatic depending on the microorganism [30,31]. In clinical practice, bacteriostatic agents such as tetracycline [32], chloramphenicol [33], linezolid [34,35], and trimethoprim-sulfamethoxazole [36] that are capable of penetrating the cerebrospinal fluid efficiently have been used to treat gram-positive bacterial meningitis, which is a life-threatening infection, where one would expect that bactericidal agents would be more effective in eradicating infection as rapidly as possible. The presumed superiority of bactericidal agents over bacteriostatic ones in the treatment of gram-positive bacterial infections tends to be misguided and is only one of many factors that determine clinical outcome. ...

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Pharmacokinetics I: PK-PD Approach, the Case of Antibiotic Drug Development

... In addition, it is difficult to interpret ELISA results when the serum antibody titer is near the cutoff threshold. Compared with PCR and ELISA, IFA (immunofluorescence assay) can be utilized to visualize the localization of viral antigens inside cells, to detect viral antibodies in serum, and to investigate viral infection processes due to its accuracy and high specificity (Koh et al. 2010;Taber et al. 1976). Moreover, semiquantitative IFA analysis of antibody level in serum can also be performed based on fluorescence intensity. ...

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Development of an indirect immunofluorescence assay for PCV3 antibody detection based on capsid protein

... prior to the introduction of IAP have been inconclusive in determining the predominant sources (maternal, nosocomial or community) of postnatal GBS transmission. 10,11,[38][39][40][41][42] Although most studies have recognised that the transmission occurs predominantly during the delivery process, 11,38-43 horizontal transmission from community and hospital sources is an important, albeit less frequent, mode for GBS transmission to neonates. Nosocomial transmission of GBS in the nurseries, through the hands of health-care workers, has been frequently reported a few decades ago, when mothers and their infants remained hospitalised for several days after delivery. ...

Reference:

Transmission of Group B Streptococcus in late-onset neonatal disease: a narrative review of current evidence

... The hips are one of the most common sites to be involved in the pediatric population, with a prevalence of 32-40% [13][14][15]. Age is a significant risk factor in this population, as most cases of septic arthritis (33%-50%) arise in children under two years of age, and the type of most common causative organisms changes among different ages [16][17][18][19][20][21]. ...

Reference:

Pediatric Fungal Septic Arthritis Following Intra-articular Administration of the Two-Month Vaccination: A Case Report