Larissa Tarskaia’s research while affiliated with University of Kansas and other places

... Эти две последовательности принадлежат к более обширному набору последовательностей (называемых гаплогруппой № 3), который в большинстве своем представлен у современного населения (от 73% до 100%, согласно исследованиям) (Lahermo et al., 1999 ;Karafet et al., 1999 ;Pakendorf et al., 2002Pakendorf et al., et 2006, в то время как его частотность у других сибирских народов и у монголов -слабее (эвенки -16%; эвены -22%; юкагиры -25%; манси -18,2%; тувинцы -9,7%; монголы -2%) (Lahermo et al., 1999 ;Karafet et al., 1999 ;Derenko et al., 2006) (Zerjal et al., 1997Karafet et al., 1999). Только буряты представляют достаточно высокую частотность данной гаплогруппы № 3: от 19% до 57%, согласно исследованиям (Zerjal et al., 1997 ;Karafet et al., 1999 ;Derenko et al., 2006). ...

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Mir drevnikh yakutov: opyt mezhdistsiplinarnykh issledovaniy (po materialam sakha-frantsuzskoy arkheologicheskoy ekspeditsii)

... The most probable scenario seems to be that during the last glacial maximum, the population that gave rise to the Native Americans ancestors persisted in Beringia for several millennia (20,000-15,000 years ago). It is assumed that this was a relatively small (from several hundred to several thousand individuals (Fagundes et al., 2018)) group of people well adapted to high latitudes and cold Possible traces of adaptation to Arctic environments at the genomic level are associated with various metabolic pathways -with melanin synthesis processes, cardiovascular system functioning, energy metabolism, and immune response genes (Mendoza-Revilla et al., 2022;Niedbalski, Long, 2022). It has also been suggested that the relaxation of negative selection in a number of protein-coding genes observed in Native Americans is also associated with the Beringian stage of population adaptation (Niedbalski, Long, 2022). ...

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The role of Beringia in human adaptation to Arctic conditions based on results of genomic studies of modern and ancient populations

... To cope with frequent exposure to cold temperatures, the human body increases its metabolic rate to maintain body temperature in an acceptable range (Gilligan, 2010(Gilligan, , 2017Leonard et al., 2002). This is why populations living in high elevations and latitudes often have elevated metabolic rates and therefore higher nutritional demands (Ge et al., 2012;Leonard et al., 2005Leonard et al., , 2014Levy et al., 2016). A high-fat or high-protein diet, including animal meats, is thereby important to compensate for the energy loss caused by elevated metabolic rates (Beall et al., 1996;Fumagalli et al., 2015;Levy et al., 2016;Speth & Spielmann, 1983). ...

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A Cold Habitat: Mapping Blade Assemblages Between the Siberian Altai and the Tibetan Plateau During MIS 3

... Furthermore, the process that triggers the dysregulation of adipokines is complex and unknown. For example, one study shows that adipose tissue hypoxia triggers the adiponectin imbalance, and they describe an inverse relationship between blood levels of adiponectin and hemoglobin in obese men [96]. ...

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An Overview of the Role of Adipokines in Cardiometabolic Diseases

... When SDs were not provided, SD was estimated from standard error (SE) (33, 35,43,48,49) or 95% confidence interval (CI) (29,50). When exact means were not provided, standard mean difference was converted from unadjusted correlation coefficients and estimated SE r (41,42,(54)(55)(56)(57)(58)(59) or converted from unadjusted odds ratio and estimated SE OR (36,60) according to accepted methods (51)(52)(53). Increased values of each health outcome compared to the lowest level of sedentary time resulted in a positive effect size. ...

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The cross‐sectional associations between objectively measured sedentary time and cardiometabolic health markers in adults – a systematic review with meta‐analysis component

... The Tuvans performed 609 ± 90 min/day of light, moderate, and vigorous activity during the observation period, of which they performed 133 ± 66 min/day of moderate to vigorous physical activity. These values are higher than the Yakut males and females who had moderate to vigorous physical activity durations of 60 min/day and 36 min/day, respectively 39 . They are also greater than reported for adults in the United States 40 and the Netherlands 41 , of which both studies included an Actigraph accelerometer and used the same physical activity intensity cut-off values as the current study. ...

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High daily energy expenditure of Tuvan nomadic pastoralists living in an extreme cold environment

... To date, there are many studies devoted to the seasonal fluctuation of pituitary-thyroid hormones in adults. Multiple studies have shown that TSH levels were higher in winter than during other seasons in both euthyroid individuals and patients with various thyroid diseases [8][9][10][11][12][13][14][15][16][17][18]. In addition, the studies using large-scale data on TSH levels have also shown a seasonal dependence of TSH levels, with a peak in the winter [19,20]. ...

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A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis?

... Paleoindian ancestors are among the many "ghost" populations that are now continually being conjured to fill in the gaps in paleogenomic phylogenies. They must have lived in Northeast Asia about 20-15,000 years ago, but they were replaced by subsequent immigration waves and so left no direct modern descendants in that region (Mooder et al. 2006;Zlojutro et al. 2008;Pugach et al. 2016;Moussa et al. 2018;Sikora et al. 2019;Mao et al. 2021). The few Siberian individuals dated to the period before Paleoindians' departure (e.g., Yana RHS, Mal'ta, Afontova Gora 2 and 3, Ust-Kyakhta-3, and Khaiyrgas-1) all seem to be ancient "cousins" rather than direct lineal ancestors of Native Americans (Yu et al. 2020;Kilinc et al. 2021). ...

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INITIAL HUMAN COLONIZATION OF THE AMERICAS, REDUX

... Climate change is causing impacts not only on our lives but also on our health. Some studies confirm the effect of environmental and weather conditions on autoimmune processes [104,105]. ...

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The Impact of Environmental Factors on the Development of Autoimmune Thyroiditis—Review

... As a result, PA becomes decoupled from direct food procurement when market goods and labor-saving technologies are introduced. Exposure to processed market foods may alter health biomarkers and influence disease outcomes (Lea et al. 2020;Liebert et al. 2013;Snodgrass et al. 2010). There is also evidence for increased sedentarism with market integration, particularly greater decreases in female PA compared to male PA and the associated increase in female fertility (Bocquet-Appel 2011; Kraft et al. 2021;Page et al. 2016;Shephard and Rode 1996;Snodgrass et al. 2006). ...

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Physical Activity and Pregnancy Norms Among Daasanach Semi-Nomadic Pastoralist Women in Northern Kenya