LINDA BROMLEY’s research while affiliated with University of Oxford and other places

... However, treatment with SAHA for an extended period (more than It has been demonstrated that low levels of oxygen free radicals can stimulate the proliferation of human fibroblasts. 39 Lung fibroblasts isolated from patients with IPF also showed increased production of mitochondrial ROS, which contributed to the senescence of these pathological cells and may be associated with their resistance to apoptosis. 40 Our results also suggest that TGFβ can induce a slight increase in mitochondrial ROS. ...

Reference:

SAHA inhibits lung fibroblast activation by increasing p66Shc expression epigenetically

... Agents such as steroids and non-steroidal antiinflammatory drugs inhibit the enzymes in this cascade, and may inhibit the effects of free radicals. This may be why Dupuytren's contracture is seen less frequently in patients with rheumatoid arthritis (27,31). ...

Reference:

An insight into Dupuytren's contracture

... Subsequently, low levels of O 2 −• and H 2 O 2 proved to activate the proliferation of both hamster [146] and human [147] fibroblasts in culture. From these initial data, several experimental pieces of evidence have suggested that ROS, other than acting as insulinactivated second messengers and stimulating cell proliferation in different cell types [148], also regulate a wide range of physiological functions. ...

Reference:

oxygen 2022 The ambiguous aspects of oxygen

... [6][7][8] In addition, superoxide anions released by fibroblasts have been suggested to play a role in cellular or subcellular function. [9][10][11] Excessive oxidant damage is prevented in the body by various enzymatic and non-enzymatic antioxidant defense systems such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, uric acid, ascorbic acid, ceruplasmin, glutathione, etc. 2,3,12,13 If the de-fense system is unable to cope with the insulting radicals, the unreacted radicals may react with the cellular components, leading ultimately to the peroxidation of membrane lipids, enzyme deactivation, damage of DNA bases, and cell death. 4,14,15 For this reason, it is important to protect the body from excessive radical damage. ...

Reference:

The Antioxidant Properties of Garlic Compounds: Allyl Cysteine, Alliin, Allicin, and Allyl Disulfide

... Уже на початку ХХ століття G. Langemak робив спроби «розчинити» стовщену фасцію за допомогою різних речовин, включаючи пепсин, трипсин, гіалуронідазу [10]. Також у різний час пропонувалися ін'єкції колхіцину [11], алопуринолу [12], кортикостероїдів [13], простагландинів, блокаторів кальцієвих каналів [14]. Однак з огляду на те, що дія цих речовин дає короткочасний ефект, їх використання не знайшло застосування. ...

Reference:

Хвороба Дюпюітрена – еволюція поглядів на етіопатогенез та лікування

... 3,10,19 One strategy to suppress tumour growth is to intervene in cancer-TME communication with antioxidants. 5 N-Acetyl cysteine (NAC), catalase and superoxide dismutase (SOD), have been found to lower ROS levels in fibroblasts, to modulate their proliferation [20][21][22] and inhibit their differentiation. 23 Antioxidants can block the fibroblast "efferent" pathway whereby the cancer cells trigger a reactive response in the stroma by releasing factors that favour cancer progression. ...

Reference:

Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model

... Study showed that increased level of hypoxanthine and xanthin oxidase are found in the palmar fascia of patients with Dupuytren disease. 19 The condition of high free radical level trigger the production of several proinflammatory cytokines including, interleukin-6 (IL-6), IL-1, IL-8, tumour necrosis factor (TNF), transforming growth factor-beta (TGF-β), and many other cytokines. 18,20 Other environmental factors and comorbidities that may also accountable as the additional risk factors associated with the disease are trauma, HIV, epilepsy, and cancer. ...

Reference:

Emerging Concept of Dupuytren’s Disease