L. Sesé’s research while affiliated with Sorbonne Nouvelle University and other places

... On the other hand, to date, very few works have explored the host genetic factors possibly associated with persistent OD [18]. Our study aims to fill this knowledge gap by applying an approach that has recently proven powerful in the identification of genes associated with the host response to COVID-19 [19][20][21], namely the analysis of the genetic landscape of rare and common variants. In particular, our study focuses on the identification of rare and common biallelic variants in genes involved in the antiviral response regulation pathway, taking advantage of Whole Genome Sequencing (WGS) data of a cohort of deeply characterized Italian patients who suffered from COVID-19 presenting with long-lasting OD. ...

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Scent of COVID-19: Whole-Genome Sequencing Analysis Reveals the Role of ACE2, IFI44, and NDUFAF4 in Long-Lasting Olfactory Dysfunction

... One recent study showed that associations between pollutant exposures and risk of interstitial lung abnormalities in COPD patients were modified by the presence of MUC5B polymorphisms (Baddour et al., 2024). On the other hand, another study could not find an influence of a MUC5B promotor polymorphism on the association of air pollution and mortality in idiopathic lung fibrosis (Sesé et al., 2024). Furthermore, to our knowledge, there is no study investigating the effect of these genes on respiratory health in a paediatric population and their modification of infants' response to air pollution. ...

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TOLLIP and MUC5B modulate the effect of ambient NO2 on respiratory symptoms in infancy

... Firstly is the lack of standardization in the diagnosis of post COVID-19 conditions. Although recommendations exist from various research institutions and medical centers, they are yet to be standardized [40,41]. Secondly is the performance of spirometry, which is an accurate and repeatable test when performed correctly. ...

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Effect of water- and land-based exercise on lung function in children with post COVID-19 condition: secondary results from a randomized controlled trial

... In this study, a pilot project was carried out to evaluate the feasibility of using AQSSs at fixed locations for epidemiological investigations. This study aimed to evaluate the use of AQSSs over a longer timeframe, which so far has not been thoroughly studied [36,37]. To this end, custom-built stationary sensor systems for NO 2 and PM 2.5 were deployed for approximately 30 days both in-and outside the homes of seven individuals diagnosed with asthma or chronic obstructive pulmonary disease (COPD). ...

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Feasibility Study on the Use of NO2 and PM2.5 Sensors for Exposure Assessment and Indoor Source Apportionment at Fixed Locations

... It was observed that COVID-19 patients presented more frequently with FRCs than the general population [18], and that females were more affected than males. Furthermore, the prevalence of FRCs was strongly associated with dyspnoea intensity and inversely correlated with the initial COVID-19 severity, but not pulmonary function tests [19]. Very close conclusions were drawn in two other monocentric French studies (Figure 1) [20,21]. ...

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European Respiratory Society International Congress, Milan, 2023: Highlights from the Assembly 1 – Respiratory clinical care and physiology

... To compare the cancer incidence in SRG variants carriers with relevant control groups, we assessed lung cancer incidence in a group of 233 TRG likely pathogenic/pathogenic variant carriers from the Bichat database with follow-up data censored on July 2023 (190 previously reported 11,[33][34][35][36] ...

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High risk of lung cancer in surfactant-related gene variant carriers

... Aunque los escasos resultados disponibles sobre este asunto tienden a mostrar el mayor riesgo de las exposiciones profesionales frente a las extra-profesionales, se necesitan más investigaciones sobre este asunto (72). Es el caso de estudios en marcha en pacientes con artritis reumatoide en los que se analizan los efectos de las potenciales exposiciones de mujeres a sílice cristalina en actividades domésticas de limpieza (73). Por último, también se ha cuestionado la diversidad de los fenotipos de enfermedades inmunomediadas entre hombres y mujeres. ...

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La remergencia de la Silicosis en España

... Recently O 3 exposure was linked to increased SSc-ILD severity and faster disease progression (23). Elevated PM 2.5 levels are consistently associated with increased risk of death or lung transplantation in patients with fILD in well-characterized cohorts with robust exposure modelling (24,25). ...

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Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease

... The COVID Human Genetic Effort (CHGE) has assembled a large cohort of SARS-CoV-2 serum-positive individuals with varying disease severity analyzed by exome or genome sequencing. We investigated whether exonic coding and splicing variants with rare minor allele frequency (MAF) in gnomAD v2 in 15 genes associated with HLH were enriched in exomes from 3269 critically ill patients relative to 1373 asymptomatic or mild COVID-19 cases (referred to as 'controls') who were roughly age matched (Fig. 1A, B), using previously reported gene burden analysis [4]. As the controls were biased towards European ethnicity (Fig. 1C), odds ratios (ORs) were adjusted by the first five ancestry principal components (PCs) for each group. ...

Reference:

No Association Between HLH-associated Gene Variants and Life-Threatening COVID-19

... Respiratory sequelae are the main cluster of PASC symptoms. After the resolution of acute disease, some patients exhibit persistent respiratory symptoms, as well as residual radiologic abnormalities and impaired lung function, which seriously affect their health-related quality of life [19,20]. To explore the contributing factors, we conducted a longitudinal assessment of the plasma proteomes and metabolomes from 6 months to 3 years after acute disease. ...

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Longitudinal multi-omics analysis of convalescent individuals with respiratory sequelae 6–36 months after COVID-19