January 1992
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23 Reads
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6 Citations
Fitoterapia
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January 1992
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23 Reads
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6 Citations
Fitoterapia
September 1990
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67 Reads
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232 Citations
Planta Medica
Tanzanian medicinal plants were extracted and tested for in vitro antimalarial activity, using the multidrug resistant K1 strain of Plasmodium falciparum. Of 49 plants investigated, extracts of three plants were found to have an IC50 between 5-10 micrograms/ml, extracts of 18 other plants showed an IC50 between 10 and 50 micrograms/ml, all others were less active. The three most active extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Hoslundia opposita Vahl. (Labiatae), and the rootbark of Lantana camara L. (Verbenaceae).
25 Reads
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47 Citations
... Thus, it was tentatively identified as Apigenin 7,4 -dimethyl ether (5-Hydroxy-4 ,7-dimethoxyflavone). This compound was previously identified in A. afra (Nkunya et al., 1992) and A. diffusa (Valant-Vetschera and Wollenweber, 1995) and was identified in the first time in A. campestris. ...
January 1992
Fitoterapia
... The antimalarial activity of CRE was investigated using the 4-day suppressive, curative, and prophylactic tests. . α-Cyperone and βselinene autoxidation products derived from C. rotundus are highly promising antimalarial compounds [31]. Furthermore, sesquiterpenoids, such as patchoulenone, caryophyllene α-oxide, 10,12peroxycalamenene, and 4,7-dimethyl-1-tetralone, have been reported to exhibit antimalarial activity against P. falciparum in culture [10]. ...
... berghei) reduces blood parasitemia by 80-90% and enhances their survival significantly. Therefore, curcumin may represent a novel treatment for malarial infection (Thebtaranonth et al., 1995;Weenen et al., 1990). ...
September 1990
Planta Medica