L.-P. Han’s research while affiliated with Harbin Medical University and other places

Aim: To observe the protective effect and mechanism of resvera on adriamycin-induced cardiotoxicity. Methods: The cardiotoxicity was induce by adriamycin (ADM) intraperitoneal injection (ip. 15 mg·kg-1). Then the protective effect of pretreatment of resvera on injured cardiomyocyes was observed. Results: Compared with the normal control group, ADM decreased the amplitude of ECG's QRS complex (P < 0.01), increased the incidence of arrhythmia (to 60%), injured myocardial ultrastructure, increased the activity of LDH, levels of NO and MDA in serum, decreased the activity of SOD, and increased the expression of p53 (P < 0.01). Compared with ADM group, 5, 10, 15 mg·kg-1 resvera decreased levels of LDH, NO and MDA, increased SOD activity, recovered the amplitude of QRS complex, decreased the incidence of arrhythmia and p53 expression (P < 0.01 or P < 0.05) in concentration-dependent manner, and lightened the myocardial ultrastructure injury. Resvera showed no significant change on normal mice except increasing the activity of SOD in serum. Conclusion: Resvera had protective effect on adriamycin-induced cardiotoxicity. The mechanism may be related to its enhancing myocardial SOD activity, inhibiting myocardial lipid peroxidation and apoptosis.