L Lis-López's research while affiliated with University of Valencia and other places

Publications (7)

Article
Full-text available
Intestinal epithelial cells (IECs) constitute a defensive physical barrier in mucosal tissues and their disruption is involved in the etiopathogenesis of several inflammatory pathologies, such as Ulcerative Colitis (UC). Recently, the succinate receptor SUCNR1 was associated with the activation of inflammatory pathways in several cell types, but li...
Article
Background Metabolomics is a recent technique that has bounced into Inflammatory Bowel Diseases (IBD) due to its capacity to elucidate specific metabolites involved in the pathology and changes in the metabolomic profile have been detected in urine, blood or feces from UC patients. G-protein coupled receptors (GPCRs) have been recently identified a...
Article
Background Ulcerative colitis (UC) is characterized by a diffuse, continuous, and chronic inflammation of mucosa and submucosa layers in the colon whose etiology is still unknown. Intestinal microbiota dysbiosis and alterations in the metabolomic profile have been reported in mucosal biopsies from Inflammatory Bowel Disease (IBD) patients. We aim t...
Article
Background Macrophages contribute to fibrosis by releasing different mediators and the pattern of secretion may vary depending on the surrounding environment. We previously described that the mRNA expression of IFNγ was significantly higher in intestinal samples from CD patients. Methods The aim of the present study is to analyze the role of IFNγ-...
Article
Full-text available
Fibrosis is a pathophysiological process of wound repair that leads to the deposit of connective tissue in the extracellular matrix. This complication is mainly associated with different pathologies affecting several organs such as lung, liver, heart, kidney, and intestine. In this fibrotic process, macrophages play an important role since they can...
Article
Background Ulcerative colitis (UC) is characterized by a diffuse, continuous, and chronic inflammation of mucosa and submucosa layers in the colon1. Inflammasome complex is involved in the intestinal homeostasis regulation, but its role in UC has not been established yet. We have recently reported that SUCNR1 mediates intestinal inflammation and fi...
Article
Background Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract whose etiology is unknown. CD is associated with complications such as fibrosis or fistula, which cannot be pharmacologically reversed, requiring repeated surgery. Although a profibrotic effect of the P2X7 receptor has been described in some scenarios s...

Citations

... In an alternative study, Dorea was more abundant in the intestines of two cohorts with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis than the healthy control cohort (Del Chierico et al., 2017). Agathobacter has been regarded as commensal in the human intestines (Bauset et al., 2022). ...
... Such important cues are the cells' microenvironmental factors (oxygen concentration, pH, etc.) and the availability of substrates for metabolism [54,55]. Given the important regulatory role of the macrophage as a gatekeeper for providing an environment supportive or destructive for tissue healing, it is likely that more categorical subtypes on the macrophage spectrum are identified as more information on the regulation of the dynamic nature of macrophage responsivity emerges [55,56]. ...