L J Scott's scientific contributions
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It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
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Publication (1)
CVID is an acquired disease with low serum immunoglobulins. Patients are classified into three groups on the ability of their B cells to secrete IgM and IgG in vitro in response to IL-2. We have now extended this patient classification to include IgA secretion and to assess whether the patients have IgA+ B cells in the circulation. B cells from alm...
Citations
... There was a significant correlation between undetectable IgM serum levels and the presence of IgM + PCs in the examined tissues suggesting that the persistent absence of serum IgM may mark an immunologically distinct subgroup of patients with more severely disturbed PC differentiation in general. IgA + PCs were absent in 9/10 LNs of CVID patients corroborating the severely disturbed differentiation of IgA secreting B cells in CVID [23]. Most of the class-switched PCs were located still within the GC and almost only IgM + PCs were located in the interfollicular space where PCs usually gather in immunocompetent individuals [24,25]. ...
