L J Scott's scientific contributions

Publication (1)

Article
CVID is an acquired disease with low serum immunoglobulins. Patients are classified into three groups on the ability of their B cells to secrete IgM and IgG in vitro in response to IL-2. We have now extended this patient classification to include IgA secretion and to assess whether the patients have IgA+ B cells in the circulation. B cells from alm...

Citations

... There was a significant correlation between undetectable IgM serum levels and the presence of IgM + PCs in the examined tissues suggesting that the persistent absence of serum IgM may mark an immunologically distinct subgroup of patients with more severely disturbed PC differentiation in general. IgA + PCs were absent in 9/10 LNs of CVID patients corroborating the severely disturbed differentiation of IgA secreting B cells in CVID [23]. Most of the class-switched PCs were located still within the GC and almost only IgM + PCs were located in the interfollicular space where PCs usually gather in immunocompetent individuals [24,25]. ...