L Ginsberg’s research while affiliated with Royal Free London NHS Foundation Trust and other places

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Publications (6)


Influence of obtaining a neurological opinion on the diagnosis and management of hospital inpatients
  • Article

January 1997

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13 Reads

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31 Citations

Journal of Neurology, Neurosurgery, and Psychiatry

M J Steiger

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S R Hammans

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L Ginsberg

Corticosteroids and the prevention of adverse reactions to myelography

July 1996

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9 Reads

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7 Citations

Side-effects of iohexol myelography were compared after pre-treatment with oral dexamethasone (n = 42) or placebo (n = 44) in a prospective, randomized, double blind, controlled clinical trial. Although myelogram side-effects were commoner in the placebo group, the differences generally did not reach statistical significance. The routine prophylactic use of oral corticosteroids for myelogram side-effects therefore cannot be recommended and our results may cast doubt on their use in the treatment of these symptoms once they have developed. These findings also suggest that inflammatory processes (allergic or chemical irritant), relating to the contrast agent itself, against which corticosteroids might have been expected to act, have at most a minor pathogenetic role in postmyelogram symptomatology.


Chronic inflammatory demyelinating polyneuropathy mimicking a lumbar spinal stenosis syndrome

September 1995

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166 Reads

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58 Citations

Journal of Neurology, Neurosurgery, and Psychiatry

A patient with chronic inflammatory demyelinating polyneuropathy (CIDP) established by biopsy developed cauda equina symptoms due to swelling of the nerve roots in the lumbar spinal canal. Magnetic resonance imaging of the lumbar spine showed profoundly thickened nerve roots from the level of the conus medullaris, filling the caudal thecal sac. Immunosuppressant treatment produced partial clinical and radiological resolution. This case shows that spinal compressive syndromes may occur in acquired hypertrophic neuropathies as well as in hereditary motor and sensory neuropathy and expands the range of the clinical presentation of CIDP.



Amyloid angiopathy and granulomatous angiitis of the central nervous system: A case responding to corticosteroid treatment

October 1988

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13 Reads

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47 Citations

Journal of Neurology

A 73-year-old woman presented with multifocal cerebral dysfunction of 1 month's duration. Cranial CT scanning revealed unusual widespread abnormalities. Brain biopsy showed amyloid angiopathy affecting vessels in the meninges and cerebral cortex, with associated granulomatous angiitis. There was no clinical evidence of extracranial vasculitis. Corticosteroid therapy produced striking clinical and radiological improvement.


Idiopathic spinal arachnoid cyst and syringomyelia

November 1987

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17 Reads

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25 Citations

The British journal of radiology

There have been isolated reports in the literature of an association between spinal arachnoid cyst and syringomyelia as a sequal to spinal trauma. We describe a case of syringomyelia of the cervico-thoracic cord associated with an idiopathic, dorsally situated intradural arachnoid cyst of the upper thoracic segments. A causal relationship is suggested.

Citations (5)


... 36 Three-quarters of patients presented with acute or subacute encephalopathy with or without focal neurological signs (46%-58%) and headache (22%-41%), with seizures in one-third. 8,11,14,23,24,27,[29][30][31]36,37,39,54,80,83 Constitutional symptoms are often absent, although patients may complain of dizziness or nausea. 3 Immune-mediated vascular function changes are believed to be responsible for iCAA symptoms, and induce relatively rapid cognitive and/ or functional decline over weeks to months, which are factors in the differential diagnosis for rapidly progressing dementia syndrome. ...

Reference:

Inflammatory Cerebral Amyloid Angiopathy: A Broad Clinical Spectrum
Amyloid angiopathy and granulomatous angiitis of the central nervous system: A case responding to corticosteroid treatment
  • Citing Article
  • October 1988

Journal of Neurology

... The majority of these cysts are located dorsally to the spinal cord (around 80% of them according to the literature) [1,2]. Previous reports have identified an association with syringomyelia in about one-third of the patients, which is thought to be related to blockage of normal cerebrospinal fluid flow and usually resolves spontaneously after the fenestration of the cyst to the subarachnoid space [3]. Although previous series have reported the presence of neurologic symptoms (either lower extremities weakness or myelopathy, which has been defined as a combination of hyperactive or pathologic reflexes with gait abnormalities, or incontinence) in all patients with surgical procedure having being indicated for all of them [1], it must be remembered that some patients may present with no (or unrelated incidental) symptoms. ...

Idiopathic spinal arachnoid cyst and syringomyelia
  • Citing Article
  • November 1987

The British journal of radiology

... Clinically, such focal hypertrophy and thickening of multiple nerves are observed under several conditions, including tumor syndrome, inflammatory disorders, infection, multiple sclerosis, chronic inflammatory demyelinating polyneuropathy (CIDP), and extracellular depositions (amyloidosis) [48,49]. Hypertrophied nerve roots have been reported for patients with CMT using pathological, ultrasonographic, and MRI imaging (Supplementary Tables S3 and S4) [50][51][52]. ...

Chronic inflammatory demyelinating polyneuropathy mimicking a lumbar spinal stenosis syndrome
  • Citing Article
  • September 1995

Journal of Neurology, Neurosurgery, and Psychiatry

... After neurology evaluation, 21-63% of patients had a change in diagnosis, and 21-88% of patients in their treatment plan. [2][3][4][5][6][7] In some studies, all neurology consultations from the hospital were evaluated, whereas, in others, consultations requested from specific departments such as intensive care units or emergency departments were assessed. [6][7][8][9] In our literature review, studies on consultation from the Department of Gynaecology, Obstetrics, and Reproductive Medicine (GORM) have yet to be ...

Influence of obtaining a neurological opinion on the diagnosis and management of hospital inpatients
  • Citing Article
  • January 1997

Journal of Neurology, Neurosurgery, and Psychiatry