L Fort-Lacoste's scientific contributions
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Publications (4)
Retinaldehyde is a key molecule in the metabolism of vitamin A by keratinocytes. In order to evaluate its range of topical activity in acne, its comedolytic effect was compared to that of retinoic acid in the same vehicle, in the rhino mouse model.
The animals were treated on the back daily for 5 consecutive days per week for 3 weeks. At the end of...
Reprint -05 61 63 45 20 -Poster n°142 s Dermal papilla cell culture Dermal papillae were isolated from the lower part of human hair follicles from the occipital region of scalp. Several papillae were placed in 35mm culture dishes contai-ning 2ml of DMEM supplemented with 20% foetal bovine serum, penicillin (100units/ml) and streptomycin (100µg/ml)....
Citations
... Action de l'eau d'Avène sur les polynucléaires neutrophiles Au cours de la réaction allergique, les polynucléaires neutrophiles s'infiltrent dans la peau, sur le lieu de la réaction allergique cutanée"; ils sont alors prêts à interagir avec les kératinocytes, en libérant la substance P : celle-ci va provoquer l'adhésion des polynucléaires neutrophiles avec les kératinocytes en vue de propager la réaction allergique. Pour étudier l'effet de l'eau d'Avène sur la substance P, Beauvais et al. 29 Des mastocytes humains, ainsi que des mastocytes de rats, ont été stimulés par différentes substances allergisantes (Fig.17). En présence d'eau d'Avène dans le milieu, et avec une stimulation par des extraits allergisants, la dégranulation est significativement inhibée, par rapport à un milieu contenant simplement de l'eau distillée. ...
Reference: De l'usage de l'eau thermale en nébuliseur
![[object Object]](https://i1.rgstatic.net/ii/profile.image/705817338716162-1545291375381_Q64/Francis-Beauvais.jpg)
... We show DX308 is a good candidate for topical use, as it is stable in the skin but readily metabolized by hepatic enzymes. Additionally, both systemic and topical administration of DX308 in mice showed no evidence of apparent toxicity or hypervitaminosis A. Rhino mice, which are often used to determine the comedolytic and anti-keratinizing activity of compounds such as retinoids, [26][27][28][29][30] showed significant skin improvements following treatment with topical DX308. Finally, we show that DX308 modulates the expression of RA-responsive genes and is predicted to inhibit inflammatory and immune response in healthy and keratinization disorder (i.e., congenital ichthyosis and DD) keratinocytes (KCs). ...
