Kun Hua's research while affiliated with Capital Medical University and other places
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Publications (32)
Background and Aims
Dapagliflozin has been widely used for the treatment of type 2 diabetes mellitus (T2DM) and heart failure (HF). However, data concerning the association between dapagliflozin and the recurrence of atrial fibrillation (AF), especially in patients following Cox Maze IV (CMIV), are rare. We aim to explore the effect of dapagliflozi...
Microplastics have been detected in human stool, lungs, and placentas, which have direct exposure to the external environment through various body cavities, including the oral/anal cavity and uterine/vaginal cavity. Crucial data on microplastic exposure in completely enclosed human organs are still lacking. Herein, we used a laser direct infrared c...
Objective: To investigate the predictive value of preoperative triglyceride-glucose (TyG) index on atrial fibrillation recurrence after valvular surgery with concurrent Cox-maze Ⅳ ablation. Methods: The data of the patients who underwent valvular surgery with concurrent Cox-maze Ⅳ ablation from June 2017 to May 2022 in the Department of Cardiac Sur...
Background
Postoperative atrial fibrillation (POAF) is the most frequent complication after heart surgery, prolonging hospital stays, as well as increasing morbidity and death. Previous studies have investigated the determinants of post-heart surgery AF; however, the risk factors contributing to POAF occurrence after coronary artery bypass graft su...
Fibrillin 1 (Fbn1) mutations cause Marfan syndrome (MFS), with aortic root dilatation, dissection, and rupture. Few studies reported the blood calcium and lipid profile of MFS, and the effect of vascular smooth muscle cell (VSMC) phenotypic switching on MFS aortic aneurysm is unclear. Here, we aimed to investigate the role of calcium-related VSMC p...
Patients with hepatitis B virus (HBV)-related liver cirrhosis (LC) are at high risk for hepatocellular carcinoma (HCC). Limitations in the early detection of HCC give rise to poor survival in this high-risk population. Here, we performed comprehensive metabolomics on health individuals and HBV-related LC patients with and without early HCC. Compare...
Lossless and efficient robotic grasping is becoming increasingly important with the widespread application of intelligent robotics in warehouse transportation, human healthcare, and domestic services. However, current sensors for feedback of grasping behavior are greatly restricted by high manufacturing cost, large volume and mass, complex circuit,...
Post-operative atrial fibrillation (POAF) is a common complication of coronary artery bypass grafting (CABG) procedures. However, the molecular mechanism of POAF remains poorly understood, hence the absence of effective prevention strategies. Here we used targeted metabolomics on pericardial fluid and serum samples from CABG patients to investigate...
Notoginseng and safflower are commonly used traditional Chinese medicines for benefiting qi and activating blood circulation. A previous study by our group showed that the compatibility of the effective components of total saponins of notoginseng (NS) and total flavonoids of safflower (SF), named NS–SF, had a preventive effect on isoproterenol (ISO...
Background:
Postoperative atrial fibrillation (POAF) is the most common complication after surgery for atherosclerotic cardiovascular disease (ASCVD) and leads to extended hospital stays and increased mortality. Myeloperoxidase (MPO) in postoperative pericardial drainage fluid is associated with an increased risk of POAF; however, the correlations...
Introduction:
This single-center study of propensity-matched data was performed to assess the effect of the no-touch saphenous vein (NTSV) harvesting technique on early- and long-term outcomes of patients after off-pump coronary artery bypass grafting (OPCABG) in China.
Methods:
A retrospective analysis of 767 patients who underwent OPCABG in th...
Background
This study was performed to assess the effect of preablation glycemic control on atrial fibrillation recurrence rates after heart valve surgery concomitant with Cox-Maze IV ablation.
Methods
Twelve-month preablation trends in glycemic control were studied. Recurrence and clinical outcome data were obtained during a mean follow-up period...
Background:
Tricuspid regurgitation (TR) usually remains asymptomatic for a long time, such that it is most often diagnosed at an advanced stage of right heart failure. The purpose of this study was to identify clinical characteristics and overall outcomes in patients with severe TR who received tricuspid valve replacement (TVR) at different clini...
Micro-distance sensor, which can accurately detect the micro-distance change, possesses significant applications in the cutting-edge technologies including biomedicine, energy storage and info-communications. However, the high cost, complicated operation and stringent testing requirements of the existing micro-distance sensors limit their widesprea...
The data of 56 patients with mitral valve prolapse undergoing thoracoscopy-assisted mitral valvuloplasty in the Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University from May 2019 to December 2020 were retrospectively analyzed. Among them, 31 cases were male and 25 cases were female, with a mean age of (45±14) years. Th...
Objective: To examine the short-term and long-term outcomes of tricuspid valve replacement (TVR) in patients with left ventricular dysfunction. Methods: The clinical data of 24 patients with left ventricular dysfunction who received TVR at Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University from November 1993 t...
Pressure sensors for living organisms can monitor both the movement behavior of the organism and pressure changes of the organ, and they have vast perspectives for the health management information platform and disease diagnostics/treatment through the micropressure changes of organs. Although pressure sensors have been widely integrated with e-ski...
Background
This study was performed to assess long-term survival and identify risk factors for acute myocardial infarction in patients complicated with ventricular septal rupture (VSR).
Method
A retrospective analysis of 116 patients with post-infarction VSR (PI-VSR) hospitalised in Beijing Anzhen Hospital from January 2008 to February 2019 was pe...
Background
Fibrosa layer stripping (FLS) technique is a new approach to remove the calcified aortic valve. In this study, we aimed to assess the effectiveness of the FLS technique by comparing it with the conventional technique in minimally invasive aortic valve replacement (MIAVR).
Methods
A prospective, single‐center, randomized controlled trial...
Objective: To assess the impacts of incomplete revascularization following off-pump coronary artery bypass grafting (OPCABG) on perioperative outcomes in octogenarians. Methods: A retrospective analysis of 242 octogenarian patients with coronary artery disease (CAD) hospitalized in Beijing Anzhen Hospital from June 2008 to July 2016 was performed....
Objective: To examine the outcome of off-pump coronary artery bypass (OPCAB) in elderly patients with left ventricular dysfunction. Methods: From June 2008 to July 2016, 252 patients aged over 80 years underwent isolated OPCAB at Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, these patients' data were col...
Objective: To compare the improvement of quality of life in the patients with left main coronary artery disease and multi-vessel disease between off-pump coronary artery bypass grafting (OPCABG) and percutaneous coronary intervention (PCI) within one year after revascularization. Methods: This study was a prospective study. Between January and July...
To improve the tensile properties and degradability of poly(butylene succinate) (PBS) for biomedical usage, biodegradable polymer blends have been developed. A series of PBS and poly(lactic acid) (PLA) blends were prepared, and their degradation behaviors in simulated body fluid for 16 months were investigated based on morphology, tensile test, wei...
Poly(butylene succinate) (PBS)/graphene oxide (GO) nanocomposites were facilely prepared via in situ polymerization. The properties of the nanocomposites were studied using FTIR, XRD, and (1)H NMR, and the state of dispersion of GO in the PBS matrix was examined by SEM. The crystallization and melting behavior of the PBS matrix in the presence of d...
To evaluate biocompatibility and cytotoxicity of PBS/PLA blend as the material for sternal fixation.
L929 cell line was used to assess the cytotoxicity and cytocompatibility of PBS/PLA blend by incubation of the cells with the aqueous extract of the material for 3 days. The cytocompatibility of the material was evaluated by observing the proliferat...
Citations
... MPs have been detected in all environmental compartments, including aquatic [8][9][10][11][12] and terrestrial ecosystems [13][14][15][16], and the atmosphere [17][18][19][20][21][22]. Furthermore, MPs have been found in animal [23][24][25][26][27] and plant tissues [28,29], and even in human blood [30][31][32]. This widespread distribution raises serious concerns about the potential impacts of MPs on ecosystem and human health. ...
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... Recently, the attention of the scientific community has been devoted to PF chemical and biochemical composition [3][4][5], but little is known about the metabolic features of this particular biofluid. To our knowledge, only two papers can be found in literature dealing with PF lipidomics [6] and metabolomics [7]. The first was conducted on an animal model (rabbit) of hypercholesterolemia and coronary atherosclerosis, whereas the second investigated PF and plasma metabolome of patients undergoing cardiac surgery for coronary artery bypass grafting. ...
... The guidelines are therefore not predicated on cumulative evidence [25,26]. Many recent studies have suggested that early surgery is better since it improves short-and long-term post-operative outcomes [27][28][29]. A prior study suggested that restoring normal life expectancy did not occur even in patients with NYHA class II symptoms [30], emphasizing the need for TR surgical management before heart failure symptoms develop [31]. ...
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... A reducing route has been utilized in cross-linking SWCNTs to one another thereby forming a network [27]. Sodium/naphthalene/N, N-dimethylacetamide/p-Diiodobenzene/SWCNTs nanoarchitectural AG has been fabricated [28], similar to fabrication of aerogel nanoarchitecture with oxidized surface used for surface-initiation polymerization, thereby fabricating CNT composite materials covalently bonded to polymeric chains prior to gelation, such as that used for polyimide/CNT AG nanoarchitectures [29]. Here, supercritical drying and chemical imidization were utilized in fabricating composite AGs materials [29]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/293161063731219-1446906452705_Q64/Xinlei-Ma-2.jpg)
... Elevated heart rate was also associated with a higher risk of malignant arrhythmias in patients with acute MI and reduced ejection fraction (29). In patients with VSR after MI, tachycardia is an independent risk factor for in-hospital mortality (19). In the case of decreased cardiac function, elevated heart rate itself is a compensatory response to maintain a stable cardiac output and sufficient perfusion of the heart and other vital organs (30). ...
... Even with the help of stateof-the-art revascularization, the improvement in myocardial ischemia is usually regional and limited. With strict adherence to evidence-based secondary prevention of CAD after PCI, the severe threats of high incidence of MACCE and low quality of life are still facing patients with CCAD (38,39). To our knowledge, there are no viable therapies or preventative strategies for these conditions. ...
... By copolymerization, materials with tailored properties can also be obtained. For instance, copolymers of lactic acid with glycolic acid (PLA-co-PGA) and with caprolactone (PLA-co-PCL) can find uses in engineering applications [28][29][30]. Since PLA and PLA-based copolymers are also resorbable, it is possible to find biomedical grades of these materials with increasing uses in biotechnology [31,32]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/277225271250947-1443107064106_Q64/Jian-Zhou-95.jpg)
... Vieira et al. [52] reported a negligible variation in Young's modulus of the fibers, in PLA-PCL fibers, during the degradation process with saline phosphate solution at pH 7.4 and a temperature of 37 °C. Likewise, Zhou et al. [63] studied mixtures of polybutylene succinate with PLA subjected to hydrolytic degradation in a solution simulating human body fluids at a pH of 7.4 and a temperature of 37 °C. They reported no statistical difference in the tensile strength of PLA until about 6 months of degradation and reported 60% in mechanical strength, indicating that PLA experiences slower degradation compared to PBS. ...
... Moisture also hinders polycondensation/polyesterification reactions of linear monomers towards high molecular weight polymers. Thus, polymerization must be performed under extremely dry conditions (distilled under inert gas flow, high vacuum, and/or very high temperatures 34,[36][37][38][39][40][41] or in organic solvents 42 . This impedes the sustainability of the process, as well as its applicability in scalable composite production. ...
... Therefore, we have used blends of PLLA with PBS in order to increase the processability of the polymer. There are some studies investigating the biocompatibility of PBS/PLA blends (Hua et al., 2010(Hua et al., , 2012. However, the potential of Schwann cellseeded PLLA/PBS polymeric sponges has not been studied in the literature yet. ...
