Kristýna Kotýnková's research while affiliated with Boston University and other places
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Publications (13)
Melanoma is commonly driven by activating mutations in the MAP kinase BRAF; however, oncogenic BRAF alone is insufficient to promote melanomagenesis. Instead, its expression induces a transient proliferative burst that ultimately ceases with the development of benign nevi comprised of growth-arrested melanocytes. The tumor suppressive mechanisms th...
Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour development1,2. Cells that undergo WGD (WGD+ cells) must adapt to accommodate their abnormal tetraploid state; however, the nature of these adaptations, and whether they confer vulnerabilitie...
Whole genome doubling (WGD) occurs early in tumorigenesis and generates genetically unstable tetraploid cells that fuel tumor development. Cells that undergo WGD (WGD+) must adapt to accommodate their abnormal tetraploid state; however, the nature of these adaptations, and whether they confer vulnerabilities that can subsequently be exploited thera...
Movie S2. Live-Cell Imaging of AcFL-C1B and AcFL-C1BQ27G Proteins after TPA Treatment, Related to Figure 1C and Figures S1D and S1E
Movie S4. Live-Cell Imaging of Cry2-mCh-ECT2 with Unilateral Blue-Light Illumination, Related to Figure 4E
Movie S1. Live-Cell Imaging of ECT2-C1B and ECT2-C1BQ27G after TPA Treatment, Related to Figure 1C
Movie S3. Live-Cell Imaging of Cry2-mCh-ECT2 with or without Blue-Light Illumination, Related to Figure 4C
Movie S5. Live-Cell Imaging of ECT2-WT and ECT2-BRCTTK Localization during Cytokinesis, Related to Figure 6C
Movie S6. Live-Cell Imaging of MyrPalm-GFP Localization during Cytokinesis, Related to Figure 6D
Cytokinesis, the final step of cell division, begins with the formation of a cleavage furrow. How the mitotic spindle specifies the furrow at the equator in animal cells remains unknown. Current models propose that the concentration of the RhoGEF ECT2 at the spindle midzone and the equatorial plasma membrane directs furrow formation. Using chemical...
Citations
... Tumorigenesis can be caused by activation of proto-oncogenes, overexpression of oncogenes, [41] or knockout of tumor suppressor genes. [42] In addition, Low cost and easy construction; highthroughput toxicity testing and drug screening; easy for genetic manipulation. ...
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... Accumulating evidence indicates that genome duplication or polyploidization is a crucial genetic trait of cancers. Pan-cancer genomic analysis has shown that a significant proportion of human solid tumors have experienced at least one round of polyploidization during their evolution [1,2]. Polyploidization is considered to lead to chromosomal instability via frequent chromosomal missegregation during proliferation and by creating aneuploidy-permissive conditions [3][4][5][6][7], which in turn facilitates cancer evolution by inducing genetic diversity [5,6]. ...
... For instance, cell cycle and mitotic progression were not perturbed in tetraploid yeast cells (Storchová et al., 2006), which may be due to the lack of spindle scaling in those strains. In contrast, tetraploid mammalian cells often progress through mitosis more slowly than their diploid counterparts (Kuznetsova et al., 2015;Paim and FitzHarris, 2019;Cohen-Sharir et al., 2020;Quinton et al., 2020), suggesting a possible delay in SAC silencing. Several recent studies, which explored the link between cell and spindle sizes and SAC function more closely (Gerhold et al., 2015(Gerhold et al., , 2018Galli and Morgan, 2016;Kyogoku and Kitajima, 2017), also produced conflicting results. ...
... The copyright holder for this preprint this version posted June 28, 2023. ; https://doi.org/10.1101/2023.06.28.546942 doi: bioRxiv preprint activation (Adriaans et al., 2019;Kotynkova et al., 2016;Su et al., 2011;Yuce et al., 2005). Active RhoA is also required for the cortical recruitment of anillin, yet the localization of anillin in iPSCs is more narrow compared to 6 mammalian cell lines that we previously characterized ( Fig. S5G; Husser et al., 2022;Piekny & Glotzer, 2008). ...
