Kirsten Lehmann’s research while affiliated with QIAGEN and other places

... Importantly, it has long been recognized that the "anticipation" or "expectation" of exercise can increase ventilatory demand and the sensation of dyspnea. (74,75) A recent study by Finnegan et al. used neuroimaging to show that specific brain activity associated with the expectation of dyspnea was correlated with symptom intensity.(76) Further, this could be modulated with Dcycloserine,(76) a brain-active drug potentially influencing the mechanisms underlying "expectations". ...

Reference:

Activity-related dyspnea and exercise intolerance in chronic obstructive pulmonary disease: recent insights

... Die Auswirkungen einer Teilnahme an ambulanten Lungensportgruppen konnten für Patienten mit COPD bisher nicht mit einer randomisiert kontrollierten Studie untersucht werden. Allerdings zeigte eine am ambulanten Lungensport teilnehmende Patientengruppe gegenüber einer Kontrollgruppe ohne Lungensport, dass die positiven Effekte eines intensiven ambulanten Rehabilitationsprogramms durch die Teilnahme am ambulanten Lungensport auch 9 Monate nach Beendigung der Rehabilitation aufrechterhalten werden konnten [9]. Dies spricht für den Einsatz des ambulanten Lungensports in der Rehabilitationsnachsorge. ...

Reference:

Ambulanter Lungensport und körperliches Training bei Patienten mit Atemwegs- und Lungenkrankheiten: Empfehlungen der Arbeitsgemeinschaft Lungensport in Deutschland und der Deutschen Atemwegsliga

... The affective dimension of dyspnea has been related to its association with the activation of limbic cerebral areas. Studies of experimental dyspnea in healthy participants, where breathing discomfort results from the application of mechanical inspiratory loads or from CO 2 stimulation, and studies of clinical dyspnea in patients have shown the involvement of limbic areas such as the anterior and posterior-insula, the cingulate and prefrontal cortices as well as the lateral periaqueductal gray (PAG) (Banzett et al., 2000;Berk et al., 2015;Brannan et al., 2001;Esser et al., 2015;Faull, Jenkinson, Martyn Ezra, & Kyle Ts Pattinson, 2016;Herigstad, Anja Hayen, & Kyle, 2011;Herigstad et al., 2017;von Leupoldt et al. 2008;von Leupoldt and Dahme, 2005;Liotti et al. 2001;Raux et al. 2013;Reijnders et al., 2020;Stewart et al., 2014). These areas are key components of the interoceptive network allowing the conscious monitoring of bodily sensations (Craig, 2002;Critchley, 2004). ...

Reference:

Breathing Control, Brain, and Bodily Self-consciousness: Toward Immersive Digiceuticals to Alleviate Respiratory Suffering

... The hippocampus is a plastic and vulnerable region of the brain that is especially susceptible to damage [23]. Hippocampal volume loss has been reported in patients with COPD [24,25], in frailty [26,27] and in patients with depression [28]. ...

Reference:

Impact of Frailty on Hippocampal Volume in Patients with Chronic Obstructive Pulmonary Disease

... NISC incorporates downward identification, which implies fear of becoming like downward comparison targets (Buunk, Taylor, Dakof, Collins, & VanYperen, 1990;Collins, 1996). So, it's not surprising that NISC has been found to be associated with negative individual outcomes such as burnout (Carmona et al., 2006), shame and embarrassment (Cheung, Gilbert, & Irons, 2004) and worry and anxiety (S. Petersen et al., 2012). The unfavorable self-evaluation of the SC status and the fear of deteriorating may lead to a lower level of pay satisfaction and a high level of turnover intentions. ...

Reference:

Understanding employee reactions to merit pay: the roles of interpretation of social comparison information and self-esteem

... The results of this study showed that patients' lung function indexes of FEV1 and the ratio of FEV1/FVC were significantly improved after 3 and 6 months of intervention, and the effect of the intervention was significantly better than that of the control group (P < 0.05). Studies have shown that poor lung function increases the number of acute exacerbations as well as hospitalization and mortality rates in patients with COPD [13,14] , and the quality of life of patients is also seriously affected by poor lung function. In this study, the O2O health management combined with the peer education management model was implemented. ...

Reference:

The Effect of O2O Education Combined with Peer Education Management Model in Patients with Chronic Obstructive Pulmonary Disease