Ki-Woong Kim's research while affiliated with Seoul National University Bundang Hospital and other places
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Publications (15)
Background
Poor social connections (eg, small networks, infrequent interactions, and loneliness) are modifiable risk factors for cognitive decline. Existing meta-analyses are limited by reporting aggregate responses, a focus on global cognition, and combining social measures into single constructs. We aimed to investigate the association between so...
Aim:
To synthesise international findings on the alcohol-dementia relationship, including representation from low- and middle-income countries.
Methods:
Individual participant data meta-analysis of 15 prospective epidemiological cohort studies from countries situated in six continents. Cox regression investigated the dementia risk associated wit...
Study objectives:
Patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) are known to be at risk of neurodegenerative diseases but the time process of neurodegeneration remains unclear and its ethnic difference is rarely discussed. The objective of this study was to investigate clinical manifestation of iRBD according to di...
Objective: To synthesise international findings on the alcohol-dementia relationship and provide a cross-national comparison of the alcohol-dementia relationship with critical evidence for the relationship between alcohol use and dementia in under-studied populations. Design and setting: Individual participant data meta-analysis of 15 prospective e...
Background:
Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied.
Methods:
We harmonized and pooled baseline data from 11 population-based cohorts from 11 countries ove...
Background
We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4).
Methods
Participants were 30,785 dementia-free individuals aged 55-103 years, from 18 longitudinal cohort studies,...
Variants in the APOE gene region may explain ethnic differences in the association of Alzheimer’s disease (AD) with ε4. Ethnic differences in allele frequencies for three APOE region SNPs (single nucleotide polymorphisms) were identified and tested for association in 19,398 East Asians (EastA), including Koreans and Japanese, 15,836 European ancest...
[This corrects the article DOI: 10.1371/journal.pone.0173075.].
Dataset of key variables of the study subjects.
(DOCX)
Background
Sleep disordered breathing (SDB) and sleep disturbances have been reported to be associated with allergic rhinitis and asthma. However, population-based studies of this issue in the elderly are rare.
Objective
To investigate the impact of self-reported rhinitis and asthma on sleep apnea and sleep quality using polysomnography in an elde...
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive multifactorial disease with limited treatment options.
Frailty is related to adverse outcomes in the elderly. However, current status and clinical significance of frailty have not been evaluated for the Korean elderly population. We aimed to investigate the usefulness of established frailty criteria for community-dwelling Korean elderly. We also tried to develop and validate a new frailty index based o...
Objectives: REM sleep behavior disorder (RBD) has received little attention in epidemiologic studies. This study aimed to determine the prevalence of probable REM sleep behavior disorder (pRBD) in the elderly population and its clinical features. Methods: A random sample of 1,588 was selected from a roster of 14,050 elderly population living in Osa...
Citations
... SHARED involves several studies with the aim to unravel the interplay between social health and biological and psychological factors. Studies include the development of a conceptual framework for social health, epidemiological studies (41,42), a systematic review on factors influencing cognitive health (17), a Group Model Building (GMB) study (43), a current study to identify social health measures and an ongoing qualitative study. The conceptual framework was iteratively developed by the interdisciplinary Social Health Stream of SHARED, consisting of a team of 11 experts, and discussed with the whole consortium. ...
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... In this regard, we identified association of the AD PRS and genes related to female infertility. Clinically, it has been observed that parity is inversely associated with risk of AD 33 . The genes related to female infertility identified in this study help explain the increased risk of AD in women, as well as the molecular mechanisms of the pathogenesis of AD in women and how parity decreases the risk of AD. ...
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... 10 The possible underlying mechanism of this correlation could be attributed to education forming brain reserve capacity or cognitive reserve (CR). 21 CR is described as brain networks with higher efficiency and more neuronal capacity which result in lower vulnerability of brain against disturbance. 21 Until now, the correlation between physical disability based on EDSS and cognitive function is not proved definitely. ...
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... For example, Filipino Americans are known to have a high risk for cardiovascular disease, hypertension, type 2 diabetes, and metabolic syndrome at lower body mass index levels, likely due to diet and genetics (Abesamis et al., 2016). Despite a higher prevalence rate in non-Hispanic White people, among APOE4 carriers, Asians had a significantly steeper memory decline when compared to White people (Makkar et al., 2020). Asian-Indians are also known to have the highest coronary artery disease rates (Ardeshna et al., 2018). ...
... To our best knowledge, this is the first sMRI-based AD prediction model that makes an input observation interpretable as a quantitative ADrelatedness index, and provides the AD-relatedness index comparable among the brain regions of a single subject and across subjects. We validated our proposed method qualitatively and quantitatively via exhaustive experiments using 3D brain sMRIs from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset [42] and private Korean 3D brain sMRIs of the Gwangju Alzheimer's and Related Dementia (GARD) cohort dataset [43]. ...
... Some of the common underlying SDB health concerns include high palate (crooked teeth), tongue tie (also weak tongue), OSA, asthma, deviated nasal septum, chronic obstructive pulmonary disease (COPD), loud snoring (facial bone structure abnormalities), hypoventilation (neuromuscular diseases and sedentary lifestyle) [11,15]. Not breathing well through the nose during sleep fragments and lowers sleep quality, and shortens the total sleep time that an individual is able to obtain [10,16,17]. ...
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... Sublingual immunotherapy (SLIT) is considered as an effective and safe treatment for children with house dust mite sensitivity and allergic rhinitis. Park [34] tested safety and efficacy of SLIT on fourteen children. The authors noted that the symptoms of allergic rhinitis started to improve after 1 month of SLIT and significantly improved after 12 months of SLIT (p < 0.05). ...
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... Although there is an agreement that cognitive frailty is associated with an increased risk of ADL or IADL disability in these studies, the use of standardised cognitive frailty or prefrailty definition and measurements would better facilitate comparisons of frailty subtypes and the risk of disability. Previous studies have similarly reported differences in predictive values on adverse outcomes depending on the operationalisation of frailty/phenotype criteria or cognitive function assessments (14,16,30,42). ...
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