Keza Motlana's research while affiliated with University of Toronto and other places

Publications (5)

Article
Ethanol consumption is a worldwide problem. Sensitivity to acute effects of ethanol influences the development of chronic ethanol abuse and ethanol dependence. Environmental and genetic factors have been found to contribute to differential effects of acute ethanol. Animal models have been employed to investigate these factors. An increasingly frequ...
Poster
Social animals can pick up signals from social group members that indicate changes in the environment, including threat or potential for injury. Signals from group members that indicate the potential for pain or injury likely range across modalities of perception, including visual cues like paw licking, vocalizations, and olfactory cues. Interestin...
Poster
Aim of Investigations* Social animals can sense signals from group members that indicate the potential for threat or harm in the environment [6], but the functional neurobiology underlying the perception of these social cues is poorly understood. Perceiving pain behavior of others has been shown to modulate the pain experience in humans that observ...
Conference Paper
Full-text available
Introduction/Aim: Social animals can sense environ- mental threats via watching group members. Research in mice has shown that when together, familiar mice express more pain than when alone, and observer mice develop sensitivity to painful stimuli after interacting with cagemates in pain. Yet the neural mechanisms that drive the enhancement of pain...
Article
Full-text available
Neuropathic pain is a chronic disease state resulting from injury to the nervous system. This type of pain often responds poorly to standard treatments and occasionally may get worse instead of better over time. Patients who experience neuropathic pain report sensitivity to cold and mechanical stimuli. Since the nociceptive system of African naked...

Citations

... Increased thigmotaxis may also be effective in nature as proximity to physical objects (the wall of the tank in the lab or the side of the trunk of an immersed tree in nature) reduces the area of attack by, and makes the prey fish less detectable to, the approaching predator [42]. Indeed, these behavioral measures have been successfully employed to quantify anxiety-like responses and changes in such responses induced in psychopharmacology analyses [43][44][45][46]. We note, however, that anxiety-like responses have been found to represent a rich behavioral repertoire, and how exactly zebrafish respond depends upon the environmental context as well as the nature of the aversive stimulus [39]. ...
... It has long been appreciated that Trpv1 is expressed in several subclasses of neurons, and more recently these populations have been described to a greater extent in several species (Goswami et al., 2014;Isensee et al., 2014;Usoskin et al., 2015;Sapio et al., 2018;Tavares-Ferreira et al., 2022). The overall pattern of expression of Trpv1 is similar to previous studies, although it appears that the RNAScope procedure, in particular, labels more neurons than most antibody-based approaches (Mitchell et al., 2010(Mitchell et al., , 2014Goswami et al., 2014;Poulson et al., 2020;Sapio et al., 2020b;Shiers et al., 2020;Hall et al., 2022;Tavares-Ferreira et al., 2022). It is also notable that the percentage of Trpv1+ neurons as assessed FIGURE 9 | Summary of identified cell types with size analysis. ...